Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Xiu Yi Kwek"'
Autor:
Xiu-Yi Kwek, Andrew R. Hall, Wei-Wen Lim, Khairunnisa Katwadi, Poh Loong Soong, Elina Grishina, Kun-Han Lin, Gustavo Crespo-Avilan, En Ping Yap, Nur Izzah Ismail, Kroekkiat Chinda, Ying Ying Chung, Heming Wei, Winston Shim, David Montaigne, Andrew Tinker, Sang-Bing Ong, Derek J. Hausenloy
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Mitochondrial dysfunction induced by acute cardiac ischemia–reperfusion (IR), may increase susceptibility to arrhythmias by perturbing energetics, oxidative stress production and calcium homeostasis. Although changes in mitochondrial morph
Externí odkaz:
https://doaj.org/article/e1c3d69e278a413bb5c1514faa5a9a65
Autor:
Benjamin Ng, Chen Xie, Liping Su, Fathima F. Kuthubudeen, Xiu-Yi Kwek, Daryl Yeong, Chee Jian Pua, Stuart A. Cook, Wei-Wen Lim
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 43:739-754
Background: Marfan Syndrome (MFS) is an inherited connective tissue disorder caused by mutations in the FBN1 (fibrillin-1) gene. Lung abnormalities are common in MFS, but their pathogenesis is poorly understood. IL11 (interleukin-11) causes aortic di
Autor:
Sang-Bing Ong, Won Hee Lee, Ning-Yi Shao, Nur Izzah Ismail, Khairunnisa Katwadi, Mim-Mim Lim, Xiu-Yi Kwek, Nathaly Anto Michel, Jiajun Li, Jordan Newson, Soroush Tahmasebi, Jalees Rehman, Kazuki Kodo, Hye Ryoun Jang, Sang-Ging Ong
Publikováno v:
Stem Cell Reports, Vol 12, Iss 3, Pp 597-610 (2019)
Summary: The relationship between diabetes and endothelial dysfunction remains unclear, particularly the association with pathological activation of calpain, an intracellular cysteine protease. Here, we used human induced pluripotent stem cells-deriv
Externí odkaz:
https://doaj.org/article/092cddd9a0e5432b99cb7cfe9007d1e2
Autor:
Xiaosai Yao, Jing Han Hong, Amrita M. Nargund, Michelle Shu Wen Ng, Hong Lee Heng, Zhimei Li, Peiyong Guan, Masahiro Sugiura, Pek Lim Chu, Loo Chien Wang, Xiaofen Ye, James Qu, Xiu Yi Kwek, Jeffrey Chun Tatt Lim, Wen Fong Ooi, Joanna Koh, Zhenxun Wang, You-Fu Pan, Yan Shan Ong, Kiat-Yi Tan, Jian Yuan Goh, Sheng Rong Ng, Luca Pignata, Dachuan Huang, Alexander Lezhava, Su Ting Tay, Minghui Lee, Xun Hui Yeo, Wai Leong Tam, Sun Young Rha, Shang Li, Ernesto Guccione, Andrew Futreal, Jing Tan, Joe Poh Sheng Yeong, Wanjin Hong, Robert Yauch, Kenneth Tou-En Chang, Radoslaw M. Sobota, Patrick Tan, Bin Tean Teh
Publikováno v:
Nature Cell Biology. 25:765-777
Autor:
Wei-Wen Lim, Benjamin Ng, Anissa Widjaja, Chen Xie, Liping Su, Nicole Ko, Sze-Yun Lim, Xiu-Yi Kwek, Stella Lim, Stuart Alexander Cook, Sebastian Schafer
Publikováno v:
PLoS ONE, Vol 15, Iss 1, p e0227505 (2020)
Interleukin 11 (IL11) is a profibrotic cytokine, secreted by myofibroblasts and damaged epithelial cells. Smooth muscle cells (SMCs) also secrete IL11 under pathological conditions and express the IL11 receptor. Here we examined the effects of SMC-sp
Externí odkaz:
https://doaj.org/article/b9436e2a31354ff8a067085ea9933b32
Autor:
Sang-Bing Ong, Xiu-Yi Kwek, Khairunnisa Katwadi, Sauri Hernandez-Resendiz, Gustavo E. Crespo-Avilan, Nur Izzah Ismail, Ying-Hsi Lin, En Ping Yap, Song-Yi Lim, K P Myu Mai Ja, Chrishan J.A. Ramachandra, Nicole Tee, Jin Jiat Toh, Winston Shim, Philip Wong, Hector A. Cabrera-Fuentes, Derek J Hausenloy
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 16, p 3972 (2019)
Background: New treatments are needed to reduce myocardial infarct size (MI) and prevent heart failure (HF) following acute myocardial infarction (AMI), which are the leading causes of death and disability worldwide. Studies in rodent AMI models show
Externí odkaz:
https://doaj.org/article/85d666df8d694e5b99e833917f91af30
Autor:
Wei-Wen Lim, Jinrui Dong, Benjamin Ng, Anissa A. Widjaja, Chen Xie, Liping Su, Xiu-Yi Kwek, Nicole G.Z. Tee, Chee Jian Pua, Sebastian Schafer, Sivakumar Viswanathan, Stuart A. Cook
Publikováno v:
Circulation research. 130(5)
Background: Marfan syndrome (MFS) is associated with TGF (transforming growth factor) β–stimulated ERK (extracellular signal-regulated kinase) activity in vascular smooth muscle cells (VSMCs), which adopt a mixed synthetic/contractile phenotype. I
Autor:
Khairunnisa Katwadi, Won Hee Lee, Nur Izzah Ismail, Jordan L. Newson, Sang Bing Ong, Sang-Ging Ong, Kazuki Kodo, Jiajun Li, Ning-Yi Shao, Xiu Yi Kwek, Jalees Rehman, Mim Mim Lim, Nathaly Anto Michel, Hye Ryoun Jang, Soroush Tahmasebi
Publikováno v:
Stem Cell Reports
Stem Cell Reports, Vol 12, Iss 3, Pp 597-610 (2019)
Stem Cell Reports, Vol 12, Iss 3, Pp 597-610 (2019)
Summary The relationship between diabetes and endothelial dysfunction remains unclear, particularly the association with pathological activation of calpain, an intracellular cysteine protease. Here, we used human induced pluripotent stem cells-derive
Autor:
Chen Xie, Liping Su, Sebastian Schafer, Sze-Yun Lim, Xiu-Yi Kwek, W. Lim, Benjamin Ng, Nicole S. J. Ko, Stuart A. Cook, Anissa A. Widjaja, Stella Lim
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 1, p e0227505 (2020)
PLoS ONE, Vol 15, Iss 1, p e0227505 (2020)
Interleukin 11 (IL11) is a profibrotic cytokine, secreted by myofibroblasts and damaged epithelial cells. Smooth muscle cells (SMCs) also secrete IL11 under pathological conditions and express the IL11 receptor. Here we examined the effects of SMC-sp
Autor:
Sze-Yun Lim, Xiu-Yi Kwek, Benjamin Ng, W. Lim, Nicole S. J. Ko, Anissa A. Widjaja, Sebastian Schafer, Liping Su, Stuart A. Cook, Stella Lim, Chen Xie
Interleukin 11 (IL11) is a profibrotic cytokine, secreted by myofibroblasts and damaged epithelial cells. Smooth muscle cells (SMCs) also secrete IL11 under pathological conditions and express the IL11 receptor. Here we examined the effects of SMC-sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::251108fb23b65f6949d36a4c16997690
https://doi.org/10.1101/756098
https://doi.org/10.1101/756098