Zobrazeno 1 - 10
of 95
pro vyhledávání: '"Xiu Fen Ming"'
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 13, p 11228 (2023)
One of the manifestations of renal aging is podocyte dysfunction and loss, which are associated with proteinuria and glomerulosclerosis. Studies show a male bias in glomerular dysfunction and chronic kidney diseases, and the underlying mechanisms rem
Externí odkaz:
https://doaj.org/article/80b960c791484a7483fe2fa4fad33226
Publikováno v:
npj Aging and Mechanisms of Disease, Vol 7, Iss 1, Pp 1-12 (2021)
Abstract The aging kidney undergoes complex changes and is vulnerable to injury and development of chronic kidney disease (CKD) with preponderance affecting more women than men. Evidence has been presented that the type-II L-arginine:ureohydrolase, a
Externí odkaz:
https://doaj.org/article/551be1cd250d48858de9a6985292e79c
Autor:
Yiqiong Ma, Duilio Michele Potenza, Guillaume Ajalbert, Andrea Brenna, Cui Zhu, Xiu-Fen Ming, Zhihong Yang
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 4, p 3587 (2023)
Hypoxia is an important risk for renal disease. The mitochondrial enzyme arginase-II (Arg-II) is expressed and/or induced by hypoxia in proximal tubular epithelial cells (PTECs) and in podocytes, leading to cellular damage. Because PTECs are vulnerab
Externí odkaz:
https://doaj.org/article/fe8e011e98824a75ba0c0ab9aabc1295
Autor:
Xiujie Liang, Duilio Michele Potenza, Andrea Brenna, Yiqiong Ma, Zhilong Ren, Xin Cheng, Xiu-Fen Ming, Zhihong Yang
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
The ureohydrolase, type-II arginase (Arg-II), is a mitochondrial enzyme metabolizing L-arginine into urea and L-ornithine and is highly expressed in renal proximal tubular cells (PTC) and upregulated by renal ischemia. Recent studies reported contrad
Externí odkaz:
https://doaj.org/article/38453dea958844b29ff98fc4d88f7054
Publikováno v:
iScience, Vol 19, Iss , Pp 39-53 (2019)
Summary: Insulin-induced AKT activation is dependent on phosphoinositide 3-kinase and opposed by tumor suppressor phosphatase and tensin homolog (PTEN). Our previous study demonstrates that myosin 1b (MYO1B) mediates arginase-II-induced activation of
Externí odkaz:
https://doaj.org/article/30d5ee254e204c818e066d41bb752316
Autor:
Zhilong Ren, Duilio Michele Potenza, Yiqiong Ma, Guillaume Ajalbert, David Hoogewijs, Xiu-Fen Ming, Zhihong Yang
Publikováno v:
Biomolecules, Vol 12, Iss 9, p 1213 (2022)
Hypoxia plays a crucial role in acute and chronic renal injury, which is attributable to renal tubular and glomerular cell damage. Some studies provide evidence that hypoxia-dependent upregulation of the mitochondrial enzyme arginase type-II (Arg-II)
Externí odkaz:
https://doaj.org/article/9c3dd308ba1b43bda78c5faa91e136de
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2021)
The impaired L-arginine/nitric oxide pathway is a well-recognized mechanism for cardiovascular and renal diseases with aging. Therefore, supplementation of L-arginine is widely proposed to boost health or as adjunct therapy for the patients. However,
Externí odkaz:
https://doaj.org/article/8f909d6fb63d4895a00e8ef0cec9c711
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 13; Pages: 11228
One of the manifestations of renal aging is podocyte dysfunction and loss, which are associated with proteinuria and glomerulosclerosis. Studies show a male bias in glomerular dysfunction and chronic kidney diseases, and the underlying mechanisms rem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::bf8c689cefcb58f4b5904249b14b01c0
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
Hypoxia plays a crucial role in the pathogenesis of cardiovascular diseases. Mitochondrial enzyme arginase type II (Arg-II) is reported to lead to endothelial dysfunction and enhance the expression of endothelial inflammatory adhesion molecules such
Externí odkaz:
https://doaj.org/article/da140f2e52a54f4eaa944a47c374b17b
Autor:
Cui Zhu, Duilio M. Potenza, Yang Yang, Guillaume Ajalbert, Kirsten D. Mertz, Stephan von Gunten, Xiu‐Fen Ming, Zhihong Yang
Publikováno v:
Zhu, Cui; Potenza, Duilio M; Yang, Yang; Ajalbert, Guillaume; Mertz, Kirsten D; von Gunten, Stephan; Ming, Xiu-Fen; Yang, Zhihong (2023). Role of pulmonary epithelial arginase-II in activation of fibroblasts and lung inflammaging. Aging cell, 22(4), e13790. Wiley 10.1111/acel.13790
Elevated arginases including type-I (Arg-I) and type-II isoenzyme (Arg-II) are reported to play a role in aging, age-associated organ inflammaging, and fibrosis. A role of arginase in pulmonary aging and underlying mechanisms are not explored. Our pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfef7051f8018f35829f2d3b4f28e2bd
