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Akademický článek

Impacts of air pollution and meteorological conditions on dry eye disease among residents in a northeastern Chinese metropolis: a six-year crossover study in a cold region

Autor: Cheng-Wei Lu, Jing Fu, Xiu-Fen Liu, Zhi-Hua Cui, Wei-Wei Chen, Li Guo, Xiao-Lan Li, Yu Ren, Fei Shao, Li-Na Chen, Ji-Long Hao

Publikováno v: Light: Science & Applications, Vol 12, Iss 1, Pp 1-14 (2023)

Abstract The purpose of this study is to explore the associations among dry eye disease (DED), air pollution, and meteorological conditions in the cold region of a northeastern Chinese metropolis (i.e., Changchun). Data on ambient air pollutants and

Externí odkaz: https://doaj.org/article/bcec6e7489b240d9accd3b2693499b92

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Akademický článek

Air pollution and meteorological conditions significantly contribute to the worsening of allergic conjunctivitis: a regional 20-city, 5-year study in Northeast China

Autor: Cheng-Wei Lu, Jing Fu, Xiu-Fen Liu, Wei-Wei Chen, Ji-Long Hao, Xiao-Lan Li, Om Prakash Pant

Publikováno v: Light: Science & Applications, Vol 10, Iss 1, Pp 1-15 (2021)

Abstract This study is the first to explore the potential associations among allergic conjunctivitis (AC), air pollution, and meteorological conditions in Northeast China. Data of meteorology, ambient atmospheric pollutants, and the incidence of alle

Externí odkaz: https://doaj.org/article/1ead196c47894567a682a5a39de45217

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Akademický článek

Resveratrol Modulates Apoptosis and Autophagy Induced by High Glucose and Palmitate in Cardiac Cells

Autor: Kui Xu, Xiu-fen Liu, Zhi-qiang Ke, Qing Yao, Shuang Guo, Chao Liu

Publikováno v: Cellular Physiology and Biochemistry, Vol 46, Iss 5, Pp 2031-2040 (2018)

Background/Aims: Diabetic cardiomyopathy is associated with increased apoptosis and suppressed autophagy in cardiac cells. The polyphenol resveratrol has shown beneficial effects in various cardiovascular diseases. This study investigated if resverat

Externí odkaz: https://doaj.org/article/83e3b75408314b3ba80fca41d0d7d990

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Supplementary Figure Legends, Supplementary Figures 1 and 2 and Supplementary Table 1 from Antitumor Effects of Immunotoxins Are Enhanced by Lowering HCK or Treatment with Src Kinase Inhibitors

Autor: Ira Pastan, David J. FitzGerald, Laiman Xiang, Xiu-Fen Liu

PDF - 950KB, Legends for Supplementary Figures 1 and 2; Supplementary Figure 1: Screening of TK siRNA library; Supplementary Figure2: Src knock down slightly increased SS1P toxicity; Supplementary Table 1: Oligos used in the study.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::600a5e6da94d21d0671cb0e2e8d8e8ea
https://doi.org/10.1158/1535-7163.22504285

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Data from In Vitro and In Vivo Activity of the Low-Immunogenic Antimesothelin Immunotoxin RG7787 in Pancreatic Cancer

Autor: Ira Pastan, Gerhard Niederfellner, Sabine Imhof-Jung, Xiu-fen Liu, Emily Mason-Osann, Kevin Hollevoet

Pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis, and new therapies are needed. RG7787 is a novel low-immunogenic antimesothelin recombinant immunotoxin (RIT), engineered to overcome the limitations of SS1P, a RIT now in clinical trials

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8d295334101bfde3d1966f3c94de7e23
https://doi.org/10.1158/1535-7163.c.6536662.v1

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Supplementary Figure 2 from In Vitro and In Vivo Activity of the Low-Immunogenic Antimesothelin Immunotoxin RG7787 in Pancreatic Cancer

Autor: Ira Pastan, Gerhard Niederfellner, Sabine Imhof-Jung, Xiu-fen Liu, Emily Mason-Osann, Kevin Hollevoet

PDF - 207K, A: Untreated KLM-1 tumors stain strongly for mesothelin. B-D: Mesothelin expression is not affected by treatment with RG7787, paclitaxel or both. IHC was done by Histoserv, Inc. according to a standard protocol. Representative pictures (1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::398f49eea6479c4aa772e39cb4eb33c6
https://doi.org/10.1158/1535-7163.22501024

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Supplementary Figures from Wide Variability in the Time Required for Immunotoxins to Kill B Lineage Acute Lymphoblastic Leukemia Cells: Implications for Trial Design

Autor: Ira Pastan, Alan S. Wayne, Xiu Fen Liu, Tyler Cunningham, Fabian Müller

Figure S1. KOPN-8 from murine BM has similar levels of CD22 and RIT sensitivity as in cell culture Figure S2. LMB-11-Alexa 647 in KOPN-8 from murine BM reaches maximal signal intensity after only 1 h circulation time Figure S3. Compared to the most a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37ad57fc44d26ae4f0ac62ee670f3e60
https://doi.org/10.1158/1078-0432.22460082

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Data from Wide Variability in the Time Required for Immunotoxins to Kill B Lineage Acute Lymphoblastic Leukemia Cells: Implications for Trial Design

Autor: Ira Pastan, Alan S. Wayne, Xiu Fen Liu, Tyler Cunningham, Fabian Müller

Purpose: Recombinant immunotoxins (rITs) targeting CD22 are highly active in hairy cell leukemia, but less so in acute lymphoblastic leukemia (ALL). This study aims to understand the variable activity of an rIT against ALL toward improving responses

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90c1eb1a8a8a5ab2a2aa5d0710acd9da
https://doi.org/10.1158/1078-0432.c.6524397

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