Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Xiu F. Hu"'
Publikováno v:
Drug Resistance Updates. 3:99-108
Drug resistance genes, such as MDR1, involved in drug efflux, and their regulation have been the subject of intense research efforts in the past 10 years. Many factors and cellular signalling pathways play a role in the regulation of MDR1 gene expres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16df236154b94d664b17d9084f6828fc
https://doi.org/10.1054/drup.2000.0121
https://doi.org/10.1054/drup.2000.0121
Autor:
Xiu F. Hu, John P. Parisot, John Zalcberg, A. E. Wakeling, Robert L. Sutherland, Mario Deluise
Publikováno v:
International Journal of Cancer. 62:480-484
Both estrogen receptor-positive (ER + ), tamoxifen-sensitive (5-21) and tamoxifen-resistant (5-23) subclones of the parental MCF-7 breast cancer cell line were used in competitive ligand binding studies involving either [ 3 H]lcl 182,780 or 4-OH-[ 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d563624f215130329d401bf16cd6b080
https://doi.org/10.1002/ijc.2910620420
https://doi.org/10.1002/ijc.2910620420
Autor:
Alison Slater, Alan F. Cowman, Dominic M. Wall, Phillip Kantharidis, Xiu F. Hu, John D. Parkin, John Zalcberg
Publikováno v:
British Journal of Cancer
Studies were carried out in a variant human multidrug-resistant (MDR) cell line CEM/A7R, which expresses very low levels of mdr1 mRNA and P-glycoprotein (P-gp). The induction of mdr1 RNA expression by three anthracyclines, (doxorubicin, daunorubicin,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::802dc63b5f0b4e30d3c9f1fea6e4cd8c
https://doi.org/10.1038/bjc.1995.180
https://doi.org/10.1038/bjc.1995.180
Autor:
M Veroni, John Zalcberg, M. De Luise, A. E. Wakeling, Xiu F. Hu, Colin K. W. Watts, Robert L. Sutherland
Publikováno v:
International Journal of Cancer. 55:873-876
Both primary and acquired resistance to the growth-inhibitory effects of anti-estrogens (e.g., tamoxifen) limits the clinical usefulness of these drugs in the treatment of breast cancer. The new, steroidal anti-estrogen ICI 182,780 was tested for its
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1c9c8c60999615130f8258ceea80c82
https://doi.org/10.1002/ijc.2910550529
https://doi.org/10.1002/ijc.2910550529
Autor:
M. De Luise, Ian C. Marschner, A. E. Wakeling, John Zalcberg, Dominic M. Wall, Xiu F. Hu, M S Ching
Publikováno v:
Cancer Chemotherapy and Pharmacology. 33:123-129
ICI 182,780, a potent, new steroidal antiestrogen without apparent agonist activity, appears to be a potent modulator of the classic multidrug resistance (MDR) phenotype in the CEM/A7, CEM/VLB100 and K562/VIN100 MDR cell lines. This reagent had no ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71428b760125e452f4354291a722c646
https://doi.org/10.1007/bf00685329
https://doi.org/10.1007/bf00685329
Autor:
Xiu F. Hu, S. T. Chou, John D. Parkin, John P. Parisot, S El-Osta, Phillip Kantharidis, John Zalcberg, Alison Slater
Publikováno v:
Monash University
Multidrug resistant prostate cancer cell lines DU 0.03 and PC 0.03 were established from the parental prostate cancer cell lines DU145 and PC-3 respectively by stepwise selection in doxorubicin (DOX) from 0.001 to 0.03mgr;g/ml. As cells adapted to ea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04c61362443fb07f41fccc977db55938
https://pubmed.ncbi.nlm.nih.gov/12497102
https://pubmed.ncbi.nlm.nih.gov/12497102
Publikováno v:
Breast cancer research and treatment. 55(3)
Earlier studies in our laboratory demonstrated that the steroidal antiestrogen ICI 182,780 is very effective in abolishing the tamoxifen-resistant proliferation of MCF 7/5-23 cells. In addition, preliminary binding studies showed that ICI 182,780 inc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd3df7ce157a3b07d496d2d182a214e0
https://pubmed.ncbi.nlm.nih.gov/10517168
https://pubmed.ncbi.nlm.nih.gov/10517168
Publikováno v:
British Journal of Cancer
The relationship between oestrogen (E2) and insulin-like growth factor-one (IGF-1) was examined in both tamoxifen-sensitive (MCF 7/5–21) and tamoxifen-resistant (MCF 7/5–23) subclones of the MCF 7 cell line. Both subclones were grown in defined,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bf7a0be5cbd00a56ffa27b9c9d39195
https://pubmed.ncbi.nlm.nih.gov/10070856
https://pubmed.ncbi.nlm.nih.gov/10070856
Publikováno v:
Journal of the National Cancer Institute. 83(3)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c04bc14c00e0f89daae4a0ac49bdde4
https://pubmed.ncbi.nlm.nih.gov/1988706
https://pubmed.ncbi.nlm.nih.gov/1988706
Publikováno v:
European journal of cancer (Oxford, England : 1990). 27(6)
ICI 164384, a new steroidal antioestrogen, entirely devoid of oestrogenic activity, modulates doxorubicin resistance in vitro. At non-cytotoxic concentrations, ICI 164384 potentiated the cytotoxicity of doxorubicin in a dose-dependent manner in both
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4509bb40f09ffa1b5f94f4bbc0d61e89
https://pubmed.ncbi.nlm.nih.gov/1648945
https://pubmed.ncbi.nlm.nih.gov/1648945