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Akademický článek

Process Development and Synthesis of Process-Related Impurities of an Efficient Scale-Up Preparation of 5,2′-Dibromo-2,4′,5′-Trihydroxy Diphenylmethanone as a New Acute Pyelonephritis Candidate Drug

Autor: Xiu E Feng, Ke Meng Cui, Qing Shan Li, Zi Cheng Wu, Fei Lei

Publikováno v: Molecules, Vol 25, Iss 3, p 468 (2020)

Based on a foregoing gram-scale laboratory process, an efficient scale-up preparation process of 5,2′-dibromo-2,4′,5′-trihydroxydiphenylmethanone (LM49-API), a new acute pyelonephritis candidate drug, was developed and validated aiming to reduc

Externí odkaz: https://doaj.org/article/f0bd7ad0bfef4afabaf93768db680c3a

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Akademický článek

Synthesis and In Vitro Protein Tyrosine Kinase Inhibitory Activity of Furan-2-yl(phenyl)methanone Derivatives

Autor: Xiu E Feng, Cheng Xiao Zhao, Wenhan Lin, Fei Lang Zheng, Shu Rong Ban, Qing Shan Li

Publikováno v: Molecules, Vol 16, Iss 6, Pp 4897-4911 (2011)

A series of novel furan-2-yl(phenyl)methanone derivatives were synthesized, and their structures were established on the basis of 1H-NMR, 13C-NMR and mass spectral data. All the prepared compounds were screened for their in vitro protein tyrosine kin

Externí odkaz: https://doaj.org/article/be3d2b4ae5c840d1a36c739106e9ae04

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Triphenylpyrazoline ketone chlorophenols as potential candidate compounds against Parkinson’s disease: design, synthesis, and biological evaluation

Autor: Ning Ning Cheng, Le Hua Zhang, Rui Ge, Xiu E. Feng, Qing Shan Li

Publikováno v: Medicinal Chemistry Research. 31:1517-1544

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0f843bc4ebf9282e8afed867e545f938
https://doi.org/10.1007/s00044-022-02932-9

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Improving endothelial cell junction integrity by diphenylmethanone derivatives at oxidative stress: A dual-action directly targeting caveolar caveolin-1

Autor: Yuan-Lin, Zhang, Hong-Xia, Yuan, Jian, Sun, Xiu-E, Feng, Jin-Hong, Ren, Yuan-Biao, Qiao, Qing-Shan, Li

Publikováno v: Toxicology and Applied Pharmacology. 455:116264

Directly targeting caveolar caveolin-1 is a potential mechanism to regulate endothelial permeability, especially during oxidative stress, but little evidence on the topic limits therapeutics discoveries. In this study, we investigated the pharmacolog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::881704eca6d8a0daaaaf57efcc798e0c
https://doi.org/10.1016/j.taap.2022.116264

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5,2′-Dibromo-2,4,5-trihydroxydiphenylmethanone, a novel immunomodulator of T lymphocytes by regulating the CD4+ T cell subset balance via activating the mitogen-activated protein kinase pathway

Autor: Fan Yang, Yuan-Lin Zhang, Qing-Shan Li, Xiu-E Feng, Bao-Guo Xiao, Rui Ge, Hong-Hong Cai

Publikováno v: International Immunopharmacology. 72:487-495

5,2'-Dibromo-2,4',5'-trihydroxydiphenylmethanone (LM49) exerted therapeutic effects against rat acute pyelonephritis by regulating immune responses, especially affecting T lymphocytes. However, its underlying action mechanism remains unclear. T lymph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::10e98b14b426fb94d2abfe1831a484f4
https://doi.org/10.1016/j.intimp.2019.04.034

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Fluorophenols bearing nitrogenated heterocycle moieties, a class of novel Keap1-Nrf2 protein-protein interaction inhibitors: synthesis, antioxidant stress screening and molecular docking

Autor: De Peng Kong, Xiu E Feng, Qing Shan Li, Rui Ge, Shu Rong Ban

Publikováno v: Medicinal Chemistry Research. 28:1319-1337

In the present study, we introduced the nitrogenated heterocycles and fluorine atoms into the 2,5′-dibromo-4,5,2′-trihydroxyl diphenylmethanone (LM49), a bromophenol analog previously reported for its strong antioxidant ability involving in the K

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::790c5d97236ea1cf10852aa898a00868
https://doi.org/10.1007/s00044-019-02376-8

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5,2′-dibromo-2,4′,5′-trihydroxydiphenylmethanone attenuates LPS-induced inflammation and ROS production in EA.hy926 cells via HMBOX1 induction

Autor: Rui Ge, Zhang Yuanlin, Hong-Xia Yuan, Bao-Guo Xiao, Xiu-E Feng, Qing-Shan Li, Enli Liu

Publikováno v: Journal of Cellular and Molecular Medicine

Inflammation and reactive oxygen species (ROS) are important factors in the pathogenesis of atherosclerosis (AS). 5,2′‐dibromo‐2,4′,5′‐trihydroxydiphenylmethanone (TDD), possess anti‐atherogenic properties; however, its underlying mecha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24d1ca5ccb259e64f52e19746388472d
https://doi.org/10.1111/jcmm.13948

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An active marine halophenol derivative attenuates lipopolysaccharide-induced acute liver injury in mice by improving M2 macrophage-mediated therapy

Autor: Xiaoyan Zhang, Bao-Guo Xiao, Fan Yang, Xiu-E Feng, QingShan Li, Jian Sun, Hong-Xia Yuan, Hong-Hong Cai, Xuan Zhang

Publikováno v: International Immunopharmacology. 96:107676

2,4',5'-Trihydroxyl-5,2'-dibromo diphenylmethanone (LM49), an active halophenol derivative synthesized by our group, which exhibits a broad spectrum of therapeutic properties, such as antioxidant and anti-inflammatory activities. In this study, we fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48a8e4a93e0d6f421d1028d1dd97857a
https://doi.org/10.1016/j.intimp.2021.107676

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A novel marine halophenol derivative attenuates lipopolysaccharide-induced inflammation in RAW264.7 cells via activating phosphoinositide 3-kinase/Akt pathway

Autor: Xiu-E Feng, Fan Yang, Hong-Hong Cai, Qingshan Li

Publikováno v: Pharmacological reports : PR. 72(4)

2,4′,5′-Trihydroxyl-5,2′-dibromo diphenylmethanone (LM49), a novel active halophenol derivative synthesized by our group from marine plants, exhibits strong anti-inflammatory activities. However, molecular machineries involved in its effect hav

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7073e551bb566b244090f829a6ff3d0c
https://pubmed.ncbi.nlm.nih.gov/32112362

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