Zobrazeno 1 - 10
of 101
pro vyhledávání: '"Xiu Bao Chang"'
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 7, Iss C, Pp 429-438 (2017)
A three-nucleotide deletion in cystic fibrosis transmembrane conductance regulator/ATP-binding cassette transporter C7 (CFTR/ABCC7) resulting in the absence of phenylalanine at 508 leads to mis-fold of the mutated protein and causes cystic fibrosis.
Externí odkaz:
https://doaj.org/article/4003528d3d554ad1b176f1b4e6a4e0ab
Autor:
Yue Xian Hou, Yanlin Jia, Xiu Bao Chang, John W. Hanrahan, Arnaud Billet, Timothy J. Jensen, John R. Riordan
Publikováno v:
Channels
Channels, Taylor & Francis, 2016, 10 (3), pp.247-251. ⟨10.1080/19336950.2015.1126010⟩
Channels, Taylor & Francis, 2016, 10 (3), pp.247-251. ⟨10.1080/19336950.2015.1126010⟩
The CFTR chloride channel is tightly regulated by phosphorylation at multiple serine residues. Recently it has been proposed that its activity is also regulated by tyrosine kinases, however the tyrosine phosphorylation sites remain to be identified.
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 18; Issue 9; Pages: 1999
International Journal of Molecular Sciences, Vol 18, Iss 9, p 1999 (2017)
International Journal of Molecular Sciences; Volume 18; Issue 9; Pages: 1999
International Journal of Molecular Sciences, Vol 18, Iss 9, p 1999 (2017)
Immunomodulatory drugs (IMiDs) are profoundly active compounds in the treatment of patients with multiple myeloma (MM). However, despite the fact that treatment with IMiDs has dramatically improved survival for patients with MM, the majority of MM pa
Autor:
Ye Xu, James Zhu, Qinqin Xu, Paul R. Langlais, Keith Stewart, Patrick Erickson, Lawrence J. Mandarino, Moulun Luo, Xiu Bao Chang, Yuanxiao Zhu, Chang Xin Shi, Yue xian Hou
Publikováno v:
BMC Cancer
Background Immunomodulatory drugs (IMiDs), such as lenalidomide, are therapeutically active compounds that bind and modulate the E3 ubiquitin ligase substrate recruiter cereblon, thereby affect steady-state levels of cereblon and cereblon binding par
Autor:
Qinqin Xu, Hou, Yue-Xian, Langlais, Paul, Erickson, Patrick, Zhu, James, Shi, Chang-Xin, Moulun Luo, Yuanxiao Zhu, Xu, Ye, Mandarino, Lawrence, Stewart, Keith, Xiu-Bao Chang
Lenalidomide induced cell death is a slow process. Cell survival was monitored by MTT assay. Figure S2. Co-transfection of pCDH.GFP.AGO2 with pNUT.CRBN.His yielded methotrexate (MTX)-resistant cells that express high levels of GFP. Pictures were take
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d01da0399cc001bd1887b11b8153aa4
Autor:
Qinqin Xu, Hou, Yue-Xian, Langlais, Paul, Erickson, Patrick, Zhu, James, Shi, Chang-Xin, Moulun Luo, Yuanxiao Zhu, Xu, Ye, Mandarino, Lawrence, Stewart, Keith, Xiu-Bao Chang
Sequence of human AGO2 small hairpin RNA (shRNA). Table S2. Proteins detected by tandem mass spectrometry analyses. Table S3. The miRNA up- or down-regulated by AGO2 shRNA. Table S4. The miRNA up- or down-regulated by lenalidomide treatment. (DOCX 15
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::713064e363ff0f7eceed283b12860213
Autor:
Andrew J. Bordner, Qing Zhao, Xiu Bao Chang, Chase A. Campbell, Yue Xian Hou, Kanagaraj Palaniyandi, Runying Yang
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1808(7):1790-1796
Structural analyses of bacterial ATP-binding-cassette transporters revealed that the glutamine residue in Q-loop plays roles in interacting with: 1) a metal cofactor to participate in ATP binding; 2) a putative catalytic water molecule to participate
Autor:
Yue Xian Hou, April Mengos, Liying Cui, Timothy J. Jensen, Xiu Bao Chang, John R. Riordan, Martina Gentzsch, Andrei A. Aleksandrov
Publikováno v:
Journal of Cell Science. 121:2814-2823
The epithelial chloride channel CFTR is a glycoprotein that is modified by two N-linked oligosaccharides. The most common mutant CFTR protein in patients with cystic fibrosis, ΔF508, is misfolded and retained by ER quality control. As oligosaccharid
Publikováno v:
Biochemistry. 47:8456-8464
Structural analyses of human MRP1-NBD1 (1),1 mouse cystic fibrosis transmembrane-conductance regulator (CFTR)-NBD1 (2), and Escherichia coli HlyB-NBD (3) revealed that the Walker A serine residue forms a hydrogen bond with the Walker B aspartic acid
Publikováno v:
Journal of Cell Science. 120:447-455
Most patients with cystic fibrosis (CF) have a single codon deletion (ΔF508) in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR) that impairs assembly of the multidomain glycoprotein. The mutant protein escapes endopl