Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Xisong KE"'
Autor:
Cheng Lian, Chunyi Zhang, Pan Tian, Qilong Tan, Yu Wei, Zixian Wang, Qin Zhang, Qixiang Zhang, Mengjie Zhong, Li-Quan Zhou, Xisong Ke, Huabing Zhang, Yao Zhu, Zhenfei Li, Jingdong Cheng, Gong-Hong Wei
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 9, Iss 1, Pp 1-22 (2024)
Abstract Epigenetic readers frequently affect gene regulation, correlate with disease prognosis, and hold significant potential as therapeutic targets for cancer. Zinc finger MYND-type containing 11 (ZMYND11) is notably recognized for reading the epi
Externí odkaz:
https://doaj.org/article/62d5d4c2a9d74c978df9588ca6d15d3f
Publikováno v:
Zhongliu Fangzhi Yanjiu, Vol 51, Iss 6, Pp 402-408 (2024)
Objective To identify small molecule inhibitors of APC-mutant colon cancer and provide lead compounds for targeted therapy of colon cancer. MethodsAPC-mutant colon cancer cell lines that stably express 7*Tcf-GFP/SV40-Cherry (7TGC) dual fluorescence r
Externí odkaz:
https://doaj.org/article/e2dfc6bd2b2b4f7f9a4c21b14b4bd665
Autor:
Yuxuan Zhang, Biying Xiao, Shuying Yuan, Lele Ding, Yongfu Pan, Yanyu Jiang, Shenghao Sun, Xisong Ke, Lili Cai, Lijun Jia
Publikováno v:
Redox Biology, Vol 76, Iss , Pp 103323- (2024)
Targeting senescence has emerged as a promising strategy for liver cancer treatment. However, the lack of a safe agent capable of inducing complete senescence and being combined with senolytics poses a limitation. Here, we screened a natural product
Externí odkaz:
https://doaj.org/article/f26e2551f1af4339999d0c7003f7079d
Autor:
Yuting Pan, Ying Xuan, Piliang Hao, Xianzhi Chen, Rong Yan, Chengqian Zhang, Xisong Ke, Yi Qu, Xue Zhang
Publikováno v:
Pharmacological Research, Vol 204, Iss , Pp 107208- (2024)
Cancer cell line is commonly used for discovery and development of anti-cancer drugs. It is generally considered that drug response remains constant for a certain cell line due to the identity of genetics thus protein patterns. Here, we demonstrated
Externí odkaz:
https://doaj.org/article/0599cc86ee45471fbd921f2cf4f14026
Autor:
Jing Zhong, Xiaofang He, Xinxin Gao, Qiaohong Liu, Yu Zhao, Ying Hong, Weize Zhu, Juan Yan, Yifan Li, Yan Li, Ningning Zheng, Yiyang Bao, Hao Wang, Junli Ma, Wenjin Huang, Zekun Liu, Yuanzhi Lyu, Xisong Ke, Wei Jia, Cen Xie, Yiyang Hu, Lili Sheng, Houkai Li
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Nonalcoholic fatty liver disease (NAFLD) is usually characterized with disrupted bile acid (BA) homeostasis. However, the exact role of certain BA in NAFLD is poorly understood. Here we show levels of serum hyodeoxycholic acid (HDCA) decreas
Externí odkaz:
https://doaj.org/article/2cabde00095247bba8fbae026c8d9d01
Publikováno v:
Pharmacological Research - Modern Chinese Medicine, Vol 7, Iss , Pp 100265- (2023)
Background: Tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2) is an oncogenic regulator of Wnt/β-catenin signaling in colon cancer. Previously we have reported a pentacyclic triterpenoid compound liquidambaric acid (LDA) inhibiting Wn
Externí odkaz:
https://doaj.org/article/704d1504d07c4ce382e10691d3b4fc75
Autor:
Dan Liu, Xing Jin, Guanzhen Yu, Mingsong Wang, Lei Liu, Wenjuan Zhang, Jia Wu, Fengying Wang, Jing Yang, Qin Luo, Lili Cai, Xi Yang, Xisong Ke, Yi Qu, Zhenye Xu, Lijun Jia, Wen-Lian Chen
Publikováno v:
Molecular Therapy: Oncolytics, Vol 23, Iss , Pp 107-123 (2021)
Metabolic reprogramming is a core hallmark of cancer and is key for tumorigenesis and tumor progression. Investigation of metabolic perturbation by anti-cancer compounds would allow a thorough understanding of the underlying mechanisms of these agent
Externí odkaz:
https://doaj.org/article/c84ed287fd68418eacb0ca80bdd3f843
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract The liposoluble tanshinones are bioactive components in Salvia miltiorrhiza and are widely investigated as anti-cancer agents, while the molecular mechanism is to be clarified. In the present study, we identified that the human fragile histi
Externí odkaz:
https://doaj.org/article/a9338087c3bd4153b81525e4508586f1
Autor:
Yaping Hua, Xing Yuan, Yun-heng Shen, Jinxin Wang, Waqas Azeem, Shuo Yang, Alexandra Gade, Seyed Mohammad Lellahi, Anne Margrete Øyan, Xisong Ke, Wei-dong Zhang, Karl-Henning Kalland
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Our drug discovery model has identified two novel STAT3 SH2 domain inhibitors 323–1 and 323–2 (delavatine A stereoisomers) in a series of experiments. In silico computational modeling, drug affinity responsive target stability (DARTS), and fluore
Externí odkaz:
https://doaj.org/article/480e443ab8d44490b85f8aa0b7dc914b
Autor:
Bojun Wang, Tiantian Wang, Huimin Zhu, Rong Yan, Xinru Li, Chengqian Zhang, Wanyu Tao, Xisong Ke, Piliang Hao, Yi Qu
Publikováno v:
Cell Reports, Vol 38, Iss 12, Pp 110538- (2022)
Summary: β-Catenin is a central component in the Wnt signaling pathway; its degradation has been tightly connected to ubiquitylation, but it is rarely examined by loss-of-function assays. Here we observe that endogenous β-catenin is not stabilized
Externí odkaz:
https://doaj.org/article/1096bcd5fdec488a9b27510bbef756d2