Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Xishan Wu"'
Autor:
Hongrui Xu, Guolong Luo, Tianbang Wu, Jiankang Hu, Chao Wang, Xishan Wu, Yan Zhang, Yong Xu, Qiuping Xiang
Publikováno v:
Biochemical and Biophysical Research Communications. 623:17-22
Inhibition of the bromodomain of the CREB (cyclic-AMP response element-binding protein) binding protein (CBP) is a particularly promising new therapeutic approach for cancer. Benzimidazole derivatives CCS1477 and its analogues (8 and 9) are highly po
Autor:
Cheng Zhang, Xishan Wu, Aihuan Wei, Xiaoxi Zhuang, Hongrui Xu, Xiaoyu Luo, Cen Huang, Qiuping Xiang, Xiaoping Zhou, Yong Xu, Yan Zhang
Publikováno v:
SSRN Electronic Journal.
Autor:
Junhua Li, Cheng Zhang, Hongrui Xu, Chao Wang, Ruibo Dong, Hui Shen, Xiaoxi Zhuang, Xiaoshan Chen, Qiu Li, Jibu Lu, Maofeng Zhang, Xishan Wu, Kerry M. Loomes, Yulai Zhou, Yan Zhang, Jinsong Liu, Yong Xu
Publikováno v:
Journal of Medicinal Chemistry. 65:5760-5799
Autor:
Qiuping Xiang, Chao Wang, Tianbang Wu, Cheng Zhang, Qingqing Hu, Guolong Luo, Jiankang Hu, Xiaoxi Zhuang, Lingjiao Zou, Hui Shen, Xishan Wu, Yan Zhang, Xiangqian Kong, Jinsong Liu, Yong Xu
Publikováno v:
Journal of Medicinal Chemistry. 65:785-810
CREB (cyclic-AMP responsive element binding protein) binding protein (CBP) is a potential target for prostate cancer treatment. Herein, we report the structural optimization of a series of 1-(indolizin-3-yl)ethan-1-one compounds as new selective CBP
Autor:
Junhua Li, Run Zhu, Xiaoxi Zhuang, Cheng Zhang, Hui Shen, Xishan Wu, Maofeng Zhang, Cen Huang, Qiuping Xiang, Linxiang Zhao, Yong Xu, Yan Zhang
Publikováno v:
Bioorganic Chemistry. 135:106495
Autor:
Qiu Li, Benqiang Yao, Shiting Zhao, Zhou Lu, Yan Zhang, Qiuping Xiang, Xishan Wu, Haonan Yu, Cheng Zhang, Junhua Li, Xiaoxi Zhuang, Donghai Wu, Yong Li, Yong Xu
Publikováno v:
Journal of medicinal chemistry. 65(10)
The design and development of agonists selectively targeting thyroid hormone receptor β (TRβ) and TRβ mutants remain challenging tasks. In this study, we first adopted the strategy of breaking the "His-Phe switch" to solve two problems, simultaneo
Autor:
Junhua Li, Run Zhu, Xiaoxi Zhuang, Cheng Zhang, Hui Shen, Xishan Wu, Maofeng Zhang, Cen Huang, Qiuping Xiang, Linxiang Zhao, Yong Xu, Yan Zhang
Publikováno v:
SSRN Electronic Journal.
Publikováno v:
Journal of Medicinal Chemistry. 62:11019-11021
The liver receptor homolog-1 (LRH-1, NR5A2), a member of the nuclear receptor superfamily, has emerged as a promising drug target for the treatment of diabetes, nonalcoholic fatty liver disease, inflammatory bowel disease, and cancers. However, the d
Autor:
Hongwu Chen, Rui Wang, Qiu Li, Chenchang Li, Junjian Wang, Yan Zhang, Xiaoqian Xue, Lingjiao Zou, Chao Wang, Jinxin Xu, Zenghong Huang, Cheng Zhang, Xiaojuan Hao, Yong Xu, Shi Yudan, Xishan Wu, Donghai Wu, Kerry M. Loomes
Publikováno v:
Journal of Medicinal Chemistry. 62:4716-4730
We report the design, optimization, and biological evaluation of nuclear receptor RORγ inverse agonists as therapeutic agents for prostate cancer treatment. The most potent compound 27 (designated as XY101) exhibited cellular activity with an IC50 v
Autor:
Qiuping Xiang, Chao Wang, Tianbang Wu, Cheng Zhang, Qingqing Hu, Guolong Luo, Jiankang Hu, Xiaoxi Zhuang, Lingjiao Zou, Hui Shen, Xishan Wu, Yan Zhang, Xiangqian Kong, Jinsong Liu, Yong Xu
Publikováno v:
Journal of Medicinal Chemistry; 1/13/2022, Vol. 65 Issue 1, p785-810, 26p