Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Xiongfong Chen"'
Bromodomain protein BRD4 directs mitotic cell division of mouse fibroblasts by inhibiting DNA damage
Autor:
Tiyun Wu, Haitong Hou, Anup Dey, Mahesh Bachu, Xiongfong Chen, Jan Wisniewski, Fuki Kudoh, Chao Chen, Sakshi Chauhan, Hua Xiao, Richard Pan, Keiko Ozato
Publikováno v:
iScience, Vol 27, Iss 7, Pp 109797- (2024)
Summary: Bromodomain protein BRD4 binds to acetylated histones to regulate transcription. BRD4 also drives cancer cell proliferation. However, the role of BRD4 in normal cell growth has remained unclear. Here, we investigated this question by using m
Externí odkaz:
https://doaj.org/article/cfc5cbda4d44456fada9dd9003dd13e3
Autor:
Keyur Talsania, Tsai-wei Shen, Xiongfong Chen, Erich Jaeger, Zhipan Li, Zhong Chen, Wanqiu Chen, Bao Tran, Rebecca Kusko, Limin Wang, Andy Wing Chun Pang, Zhaowei Yang, Sulbha Choudhari, Michael Colgan, Li Tai Fang, Andrew Carroll, Jyoti Shetty, Yuliya Kriga, Oksana German, Tatyana Smirnova, Tiantain Liu, Jing Li, Ben Kellman, Karl Hong, Alex R. Hastie, Aparna Natarajan, Ali Moshrefi, Anastasiya Granat, Tiffany Truong, Robin Bombardi, Veronnica Mankinen, Daoud Meerzaman, Christopher E. Mason, Jack Collins, Eric Stahlberg, Chunlin Xiao, Charles Wang, Wenming Xiao, Yongmei Zhao
Publikováno v:
Genome Biology, Vol 23, Iss 1, Pp 1-33 (2022)
Abstract Background The cancer genome is commonly altered with thousands of structural rearrangements including insertions, deletions, translocation, inversions, duplications, and copy number variations. Thus, structural variant (SV) characterization
Externí odkaz:
https://doaj.org/article/3cca47d9f72844a39a3e5ac2ef139231
Autor:
Yongmei Zhao, Li Tai Fang, Tsai-wei Shen, Sulbha Choudhari, Keyur Talsania, Xiongfong Chen, Jyoti Shetty, Yuliya Kriga, Bao Tran, Bin Zhu, Zhong Chen, Wanqiu Chen, Charles Wang, Erich Jaeger, Daoud Meerzaman, Charles Lu, Kenneth Idler, Luyao Ren, Yuanting Zheng, Leming Shi, Virginie Petitjean, Marc Sultan, Tiffany Hung, Eric Peters, Jiri Drabek, Petr Vojta, Roberta Maestro, Daniela Gasparotto, Sulev Kõks, Ene Reimann, Andreas Scherer, Jessica Nordlund, Ulrika Liljedahl, Jonathan Foox, Christopher E. Mason, Chunlin Xiao, Huixiao Hong, Wenming Xiao
Publikováno v:
Scientific Data, Vol 8, Iss 1, Pp 1-14 (2021)
Measurement(s) Somatic Mutation Analysis Technology Type(s) whole genome sequencing • Whole Exome Sequencing Factor Type(s) sequencing platform • sample prepration • library preparation • bioinformatics method Sample Characteristic - Organism
Externí odkaz:
https://doaj.org/article/df99660883fb470bb2307f5ae2b58917
Autor:
Lulu Yu, Vladimir Majerciak, Xiang-Yang Xue, Aayushi Uberoi, Alexei Lobanov, Xiongfong Chen, Maggie Cam, Stephen H Hughes, Paul F Lambert, Zhi-Ming Zheng
Publikováno v:
PLoS Pathogens, Vol 17, Iss 8, p e1009812 (2021)
MmuPV1 is a useful model for studying papillomavirus-induced tumorigenesis. We used RNA-seq to look for chimeric RNAs that map to both MmuPV1 and host genomes. In tumor tissues, a higher proportion of total viral reads were virus-host chimeric juncti
Externí odkaz:
https://doaj.org/article/46e09fb244e243b39563baa1fec48547
Autor:
Takaaki Watanabe, Michael Marotta, Ryusuke Suzuki, Scott J. Diede, Stephen J. Tapscott, Atsushi Niida, Xiongfong Chen, Lila Mouakkad, Anna Kondratova, Armando E. Giuliano, Sandra Orsulic, Hisashi Tanaka
Publikováno v:
Cell Reports, Vol 21, Iss 8, Pp 2223-2235 (2017)
Naturally stalled replication forks are considered to cause structurally abnormal chromosomes in tumor cells. However, underlying mechanisms remain speculative, as capturing naturally stalled forks has been a challenge. Here, we captured naturally st
Externí odkaz:
https://doaj.org/article/c0675a00addd416389382cdd66edb9e8
Autor:
Xiang-Yang Xue, Vladimir Majerciak, Aayushi Uberoi, Bong-Hyun Kim, Deanna Gotte, Xiongfong Chen, Maggie Cam, Paul F Lambert, Zhi-Ming Zheng
Publikováno v:
PLoS Pathogens, Vol 13, Iss 11, p e1006715 (2017)
Mouse papillomavirus type 1 (MmuPV1) provides, for the first time, the opportunity to study infection and pathogenesis of papillomaviruses in the context of laboratory mice. In this report, we define the transcriptome of MmuPV1 genome present in papi
Externí odkaz:
https://doaj.org/article/8471e1967fc34e55a3920e13b65b2066
Autor:
M Cecilia Cirio, Zhao Hui, Caroline E Haldin, Chiara Cianciolo Cosentino, Carsten Stuckenholz, Xiongfong Chen, Sung-Kook Hong, Igor B Dawid, Neil A Hukriede
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e18858 (2011)
In the vertebrate embryo, the kidney is derived from the intermediate mesoderm. The LIM-class homeobox transcription factor lhx1 is expressed early in the intermediate mesoderm and is one of the first genes to be expressed in the nephric mesenchyme.
Externí odkaz:
https://doaj.org/article/3102822b6cc94763a1049ea3915ef634
Autor:
Christine Alewine, Xianyu Zhang, Xiongfong Chen, Rakan Albalawy, Danielle Arons, Salma El-Behaedi, Michael Rudloff, Leela Rani Avula
Figure Legends and Supplementary Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1faac0ba5a245982ae903589fc46ba99
https://doi.org/10.1158/1541-7786.22517979.v1
https://doi.org/10.1158/1541-7786.22517979.v1
Autor:
Christine Alewine, Xianyu Zhang, Xiongfong Chen, Rakan Albalawy, Danielle Arons, Salma El-Behaedi, Michael Rudloff, Leela Rani Avula
In vivo BLI of mice inoculated IP with Luc/GFP+ KLM1 Mock or KO#2 on day 3 (D3), 7 (D7) and 14 (D14) post-injection.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d415b30cee3052634e85ab4c8a4573d
https://doi.org/10.1158/1541-7786.22517994
https://doi.org/10.1158/1541-7786.22517994
Autor:
Corrine Corrina R. Hartford, Roshan L. Shrestha, Lorinc Pongor, Yongmei Zhao, Xiongfong Chen, Caroline Fromont, Ritu Chaudhary, Xiao Ling Li, Katherine R. Pasterczyk, Ravi Kumar, Bruna R. Muys, Dimitrios Tsitsipatis, Raj Chari, Myriam Gorospe, Mirit I. Aladjem, Javed Khan, Munira A. Basrai, Ioannis Grammatikakis, Ashish Lal
Publikováno v:
Mol Cell Biol
PURPL is a p53-induced lncRNA that suppresses basal p53 levels. Here, we investigated PURPL upon p53 activation in liver cancer cells, where it is expressed at significantly higher levels than other cell types. Using isoform sequencing, we discovered