Zobrazeno 1 - 10
of 116
pro vyhledávání: '"Xiong‐Jian Luo"'
Autor:
Shiwu Li, Changguo Ma, Yifan Li, Rui Chen, Yixing Liu, Li Pear Wan, Qiuxia Xiong, Chuang Wang, Yongxia Huo, Xinglun Dang, Yongfeng Yang, Luxian Lv, Xi Chen, Nengyin Sheng, Wenqiang Li, Xiong-Jian Luo
Publikováno v:
Translational Psychiatry, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract The missense variant rs13107325 (C/T, p.Ala391Thr) in SLC39A8 consistently showed robust association with schizophrenia in recent genome-wide association studies (GWASs), suggesting the potential pathogenicity of this non-synonymous risk var
Externí odkaz:
https://doaj.org/article/b00f5596114d497d98229245a2eff30e
Autor:
Rui Chen, Zhihui Yang, Jiewei Liu, Xin Cai, Yongxia Huo, Zhijun Zhang, Ming Li, Hong Chang, Xiong-Jian Luo
Publikováno v:
Genome Medicine, Vol 14, Iss 1, Pp 1-20 (2022)
Abstract Background Genome-wide association studies (GWASs) have identified multiple risk loci for bipolar disorder (BD). However, pinpointing functional (or causal) variants in the reported risk loci and elucidating their regulatory mechanisms remai
Externí odkaz:
https://doaj.org/article/6fcb5061bf8d4339b3c40423d845fca3
Autor:
Rui Chen, Jiewei Liu, Shiwu Li, Xiaoyan Li, Yongxia Huo, Yong-Gang Yao, Xiao Xiao, Ming Li, Xiong-Jian Luo
Publikováno v:
BMC Medicine, Vol 20, Iss 1, Pp 1-18 (2022)
Abstract Background Genome-wide association studies (GWASs) have identified multiple risk loci for Parkinson’s disease (PD). However, identifying the functional (or potential causal) variants in the reported risk loci and elucidating their roles in
Externí odkaz:
https://doaj.org/article/903a6fb3fbbe4cf59705ec86a9b109a1
Autor:
Jiewei Liu, Shiwu Li, Xiaoyan Li, Wenqiang Li, Yongfeng Yang, Suqin Guo, Luxian Lv, Xiao Xiao, Yong-Gang Yao, Fanglin Guan, Ming Li, Xiong-Jian Luo
Publikováno v:
BMC Medicine, Vol 19, Iss 1, Pp 1-15 (2021)
Abstract Background Over 200 schizophrenia risk loci have been identified by genome-wide association studies (GWASs). However, the majority of risk loci were identified in populations of European ancestry (EUR), potentially missing important biologic
Externí odkaz:
https://doaj.org/article/fc9fe80d0f57443b8c33029d9308ee96
Transcriptome-wide association study identifies new susceptibility genes and pathways for depression
Autor:
Xiaoyan Li, Xi Su, Jiewei Liu, Huijuan Li, Ming Li, the 23andMe Research Team, Wenqiang Li, Xiong-Jian Luo
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Depression is the most prevalent mental disorder with substantial morbidity and mortality. Although genome-wide association studies (GWASs) have identified multiple risk variants for depression, due to the complicated gene regulatory mechani
Externí odkaz:
https://doaj.org/article/9e7a5aa969314fdb8b7ff0556619e225
Autor:
Suqin Guo, Jiewei Liu, Wenqiang Li, Yongfeng Yang, Luxian Lv, Xiao Xiao, Ming Li, Fanglin Guan, Xiong-Jian Luo
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Early onset schizophrenia (EOS, defined as first onset of schizophrenia before age 18) is a rare form of schizophrenia (SCZ). Though genome-wide association studies (GWASs) have identified multiple risk variants for SCZ, most of the cases in
Externí odkaz:
https://doaj.org/article/61817dd0ad464fbc9ebe1a9a12623dec
Autor:
Yifan Li, Changguo Ma, Shiwu Li, Junyang Wang, Wenqiang Li, Yongfeng Yang, Xiaoyan Li, Jiewei Liu, Jinfeng Yang, Yixing Liu, Kaiqin Li, Jiao Li, Di Huang, Rui Chen, Luxian Lv, Xiao Xiao, Ming Li, Xiong‐Jian Luo
Publikováno v:
Advanced Science, Vol 9, Iss 6, Pp n/a-n/a (2022)
Abstract Genome‐wide association studies have identified 3p21.1 as a robust risk locus for schizophrenia. However, the underlying molecular mechanisms remain elusive. Here a functional regulatory variant (rs2535629) is identified that disrupts CTCF
Externí odkaz:
https://doaj.org/article/62b5235d18a44da7a3e4343db9726f6d
Autor:
Wenqiang Li, Chu-Yi Zhang, Jiewei Liu, Fanglin Guan, Minglong Shao, Luwen Zhang, Qing Liu, Yongfeng Yang, Xi Su, Yan Zhang, Xiao Xiao, Xiong-Jian Luo, Ming Li, Luxian Lv
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
Background: Shared psychopathological features and mechanisms have been observed between schizophrenia (SZ) and bipolar disorder (BD), but their common risk genes and full genetic architectures remain to be fully characterized. The genome-wide associ
Externí odkaz:
https://doaj.org/article/1f34c45d803f4a508101e2f5960a4649
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
Anxiety disorders are common mental disorders that often result in disability. Recently, large-scale genome-wide association studies (GWASs) have identified several novel risk variants and loci for anxiety disorders (or anxiety traits). Nevertheless,
Externí odkaz:
https://doaj.org/article/413dd6d926844d7d80f3cfbb2216cff8
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
Epilepsy (affects about 70 million people worldwide) is one of the most prevalent brain disorders and imposes a huge economic burden on society. Epilepsy has a strong genetic component. In this study, we perform the largest genome-wide meta-analysis
Externí odkaz:
https://doaj.org/article/7e2e1a5f05b0466bba3e182eaeb414b6