Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Xiomara Pedreiturria"'
Autor:
Hasan Hüseyin Hendek, Alina Blusch, Neele Heitmann, Sarah Oberhagemann, Seray Demir, Xiomara Pedreiturria, Ralf Gold, Simon Faissner
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract So far, only a small number of medications are effective in progressive multiple sclerosis (MS). The sphingosine-1-phosphate-receptor (S1PR)-1,5 modulator siponimod, licensed for progressive MS, is acting both on peripheral immune cells and
Externí odkaz:
https://doaj.org/article/893365440976485ea1a55231324646ed
Autor:
Simon Faissner, Neele Heitmann, Ricarda Rohling, Ulas Ceylan, Marielena Bongert, Carlos Plaza-Sirvent, Corinna Marheinecke, Xiomara Pedreiturria, Ilya Ayzenberg, Kerstin Hellwig, Ingo Schmitz, Stephanie Pfaender, Ralf Gold
Publikováno v:
Therapeutic Advances in Neurological Disorders, Vol 15 (2022)
Background: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has tremendous implications for the management of patients with autoimmune conditions such as multiple sclerosis (MS) under immune therapies targeting CD20 + B cell
Externí odkaz:
https://doaj.org/article/a4d057ff0a6b4ddcb77dc1af21113424
Autor:
Lisa Thiele née Schrewe, Kirsten Guse, Silvia Tietz, Jana Remlinger, Seray Demir, Xiomara Pedreiturria, Robert Hoepner, Anke Salmen, Maximilian Pistor, Timothy Turner, Britta Engelhardt, Dirk M. Hermann, Fred Lühder, Stefan Wiese, Andrew Chan
Publikováno v:
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-9 (2020)
Abstract Background The multi-drug resistance transporter ABCG2, a member of the ATP-binding cassette (ABC) transporter family, mediates the efflux of different immunotherapeutics used in multiple sclerosis (MS), e.g., teriflunomide (teri), cladribin
Externí odkaz:
https://doaj.org/article/7192c5f5a49342408e5e811a46b98eff
Autor:
Kalliopi Pitarokoili, Melissa Sgodzai, Thomas Grüter, Hussein Bachir, Jeremias Motte, Björn Ambrosius, Xiomara Pedreiturria, Min-Suk Yoon, Ralf Gold
Publikováno v:
Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-12 (2019)
Abstract Background Corticosteroids dominate in the treatment of chronic autoimmune neuropathies although long-term use is characterized by devastating side effects. Methods We introduce the intrathecal application of the synthetic steroid triamcinol
Externí odkaz:
https://doaj.org/article/1a9413c58e10494fa9d8621593d13d04
Laquinimod protects the optic nerve and retina in an experimental autoimmune encephalomyelitis model
Autor:
Anna T. Wilmes, Sabrina Reinehr, Sandra Kühn, Xiomara Pedreiturria, Laura Petrikowski, Simon Faissner, Ilya Ayzenberg, Gesa Stute, Ralf Gold, H. Burkhard Dick, Ingo Kleiter, Stephanie C. Joachim
Publikováno v:
Journal of Neuroinflammation, Vol 15, Iss 1, Pp 1-17 (2018)
Abstract Background The oral immunomodulatory agent laquinimod is currently evaluated for multiple sclerosis (MS) treatment. Phase II and III studies demonstrated a reduction of degenerative processes. In addition to anti-inflammatory effects, laquin
Externí odkaz:
https://doaj.org/article/64491b604511419db58735eb8853aa3a
Autor:
Jeremias Motte, Björn Ambrosius, Thomas Grüter, Hussein Bachir, Melissa Sgodzai, Xiomara Pedreiturria, Kalliopi Pitarokoili, Ralf Gold
Publikováno v:
Journal of Neuroinflammation, Vol 15, Iss 1, Pp 1-13 (2018)
Abstract Background Autoimmune neuropathies are common PNS disorders and effective treatment is challenging. Environmental influence and dietary components are known to affect the course of autoimmune diseases. Capsaicin as pungent component of chili
Externí odkaz:
https://doaj.org/article/b77198d1a94c46898d8e626381e0da9a
Autor:
Björn Ambrosius, Kalliopi Pitarokoili, Lisa Schrewe, Xiomara Pedreiturria, Jeremias Motte, Ralf Gold
Publikováno v:
Journal of Neuroinflammation, Vol 14, Iss 1, Pp 1-9 (2017)
Abstract Background Fingolimod, a sphingosine-1-phosphate receptor modulator with well-described immunomodulatory properties involving peripheral immune cell trafficking, was the first oral agent approved for the treatment of relapsing remitting mult
Externí odkaz:
https://doaj.org/article/7e84880744894ca7bad061b1f8c0e95b
Autor:
Kalliopi Pitarokoili, Hussein Bachir, Melissa Sgodzai, Thomas Grüter, Steffen Haupeltshofer, Alexander Duscha, Xiomara Pedreiturria, Jeremias Motte, Ralf Gold
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Objective: Dimethyl fumarate (DMF) exerts immunomodulatory and neuroprotective effects in the animal model of experimental autoimmune neuritis (EAN) in the Lewis rat. DMF has been shown to modulate gut microbiota in veterinary medicine, however the e
Externí odkaz:
https://doaj.org/article/a493f2f520a847dd874394903a831922
Autor:
Judith Metzdorf, Zaynab Hobloss, Sibylle Schlevogt, Ilya Ayzenberg, Sarah Stahlke, Xiomara Pedreiturria, Steffen Haupeltshofer, Ralf Gold, Lars Tönges, Ingo Kleiter
Publikováno v:
Frontiers in Neuroscience, Vol 13 (2019)
BackgroundCranial irradiation is a common therapy for the treatment of brain tumors, but unfortunately patients suffer from side effects, particularly cognitive impairment, caused by neurodegenerative and neuroinflammatory mechanisms. Finding a thera
Externí odkaz:
https://doaj.org/article/1ff3b6d43f3e49c5b4b89b722eaaa9a6
Autor:
Thomas Grüter, Nuwin Mohamad, Niklas Rilke, Alina Blusch, Melissa Sgodzai, Seray Demir, Xiomara Pedreiturria, Katharina Lemhoefer, Barbara Gisevius, Aiden Haghikia, Anna Lena Fisse, Jeremias Motte, Ralf Gold, Kalliopi Pitarokoili
Publikováno v:
Proceedings of the National Academy of Sciences. 120
In inflammatory neuropathies, oxidative stress results in neuronal and Schwann cell (SC) death promoting early neurodegeneration and clinical disability. Treatment with the short-chain fatty acid propionate showed a significant immunoregulatory and n