Siponimod treatment response shows partial BDNF dependency in multiple sclerosis models

Autor: Hasan Hüseyin Hendek, Alina Blusch, Neele Heitmann, Sarah Oberhagemann, Seray Demir, Xiomara Pedreiturria, Ralf Gold, Simon Faissner

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)

Abstract So far, only a small number of medications are effective in progressive multiple sclerosis (MS). The sphingosine-1-phosphate-receptor (S1PR)-1,5 modulator siponimod, licensed for progressive MS, is acting both on peripheral immune cells and

Externí odkaz: https://doaj.org/article/893365440976485ea1a55231324646ed

Preserved T-cell response in anti-CD20-treated multiple sclerosis patients following SARS-CoV-2 vaccination

Autor: Simon Faissner, Neele Heitmann, Ricarda Rohling, Ulas Ceylan, Marielena Bongert, Carlos Plaza-Sirvent, Corinna Marheinecke, Xiomara Pedreiturria, Ilya Ayzenberg, Kerstin Hellwig, Ingo Schmitz, Stephanie Pfaender, Ralf Gold

Publikováno v: Therapeutic Advances in Neurological Disorders, Vol 15 (2022)

Background: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has tremendous implications for the management of patients with autoimmune conditions such as multiple sclerosis (MS) under immune therapies targeting CD20 + B cell

Externí odkaz: https://doaj.org/article/a4d057ff0a6b4ddcb77dc1af21113424

The Transcriptional Activator Krüppel-like Factor-6 Is Required for CNS Myelination

Autor: Elena Zaslavsky, Patrizia Casaccia, Goutham Narla, Youngmin A. Lee, Sam Horng, Xiomara Pedre, Yuko Hara, John N. Mariani, Benjamin M. Laitman, German Nudelman, Q. Richard Lu, Cedric S. Raine, Linnea Asp, Elisabeth G. Kramer, Candice Chapouly, Jingya Zhang, Jia Liu, David A. Braun, Nesanet Mitiku, Setsu Sawai, Scott L. Friedman, Gareth R. John, Hannah Loo, Natalie Burlant

Publikováno v: BASE-Bielefeld Academic Search Engine
PLoS Biology
PLoS Biology, Vol 14, Iss 5, p e1002467 (2016)
Plos Biology
Plos Biology, In press, 14 (5), pp.e1002467. ⟨10.1371/journal.pbio.1002467⟩

Growth factors of the gp130 family promote oligodendrocyte differentiation, and viability, and myelination, but their mechanisms of action are incompletely understood. Here, we show that these effects are coordinated, in part, by the transcriptional

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ae6b39c0248379dfad570aa8eddf716
https://doi.org/10.1371/journal.pbio.1002467

Intrathecal triamcinolone acetonide exerts anti-inflammatory effects on Lewis rat experimental autoimmune neuritis and direct anti-oxidative effects on Schwann cells

Autor: Kalliopi Pitarokoili, Melissa Sgodzai, Thomas Grüter, Hussein Bachir, Jeremias Motte, Björn Ambrosius, Xiomara Pedreiturria, Min-Suk Yoon, Ralf Gold

Publikováno v: Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-12 (2019)

Abstract Background Corticosteroids dominate in the treatment of chronic autoimmune neuropathies although long-term use is characterized by devastating side effects. Methods We introduce the intrathecal application of the synthetic steroid triamcinol

Externí odkaz: https://doaj.org/article/1a9413c58e10494fa9d8621593d13d04

Capsaicin-enriched diet ameliorates autoimmune neuritis in rats

Autor: Jeremias Motte, Björn Ambrosius, Thomas Grüter, Hussein Bachir, Melissa Sgodzai, Xiomara Pedreiturria, Kalliopi Pitarokoili, Ralf Gold

Publikováno v: Journal of Neuroinflammation, Vol 15, Iss 1, Pp 1-13 (2018)

Abstract Background Autoimmune neuropathies are common PNS disorders and effective treatment is challenging. Environmental influence and dietary components are known to affect the course of autoimmune diseases. Capsaicin as pungent component of chili

Externí odkaz: https://doaj.org/article/b77198d1a94c46898d8e626381e0da9a