Antibacterial and Cytotoxic Bridged and Ring Cleavage Angucyclinones From a Marine Streptomyces sp

Autor: Lin Guo, Lu Zhang, Qiaoli Yang, Bo Xu, Xinzhen Fu, Ming Liu, Zhi Li, Shumin Zhang, Zeping Xie

Publikováno v: Frontiers in Chemistry, Vol 8 (2020)

Chemical investigation of a marine-derived Streptomyces sp. KCB-132, cultivated in liquid ISP2 medium, had led to the discovery of three C-ring cleavage angucyclinone N-heterocycles, pratensilins A–C, with a novel spiro indolinone-naphthofuran skel

Externí odkaz: https://doaj.org/article/e01989f5dbe84c8db448f3165aaec849

Enhanced Intramuscular Bioavailability of Cannabidiol Using Nanocrystals: Formulation, In Vitro Appraisal, and Pharmacokinetics

Autor: Xinzhen Fu, Shiji Xu, Zhi Li, Kun Chen, Huaying Fan, Yu Wang, Zeping Xie, Lijuan Kou, Shumin Zhang

Publikováno v: AAPS PharmSciTech. 23(3)

Cannabidiol (CBD) has poor water solubility and is subjected to extensive first-pass metabolism. These absorption obstacles are responsible for low and variable oral bioavailability of CBD. This study endeavored to improve CBD bioavailability by intr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3aa04291f30f1fc3a361a42e3bd9ca29
https://pubmed.ncbi.nlm.nih.gov/35288801

Intensity modulated radiotherapy in combination with endocrinotherapy in the treatment of middle and advanced Prostatic Cancer

Autor: Xinzhen Fu, Shufen Zhao, Sumei Zhang

Publikováno v: Pakistan Journal of Medical Sciences. 35

Objective: To evaluate the clinical efficacy of intensity modulated radiation therapy and endocrinotherapy for middle and advanced prostate cancer. Methods: Total 104 elderly patients with middle and advanced prostate cancer who were admitted to our

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b632e83a81a9a103e7f425a5c131e766
https://doi.org/10.12669/pjms.35.5.591

N-Methyl-d-aspartate receptor and L-type voltage-gated Ca2+ channel activation mediate proline-rich tyrosine kinase 2 phosphorylation during cerebral ischemia in rats

Autor: Jun Guo, Bo Song, Xinzhen Fu, Guang-Yi Zhang, Fanjie Meng, Xue-bo Yan

Publikováno v: Neuroscience Letters. 355:177-180

Cerebral ischemia induces rapid efflux of glutamate into the extracellular space contributing to excessive activation of glutamate receptors in postsynaptic cells, particularly N-methyl-D-aspartate (NMDA) receptors, which triggers the neuron lesion t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ab214a1a5bb083a6967bd32597072a8
https://doi.org/10.1016/j.neulet.2003.10.076

Intensity modulated radiotherapy in combination with endocrinotherapy in the treatment of middle and advanced Prostatic Cancer.

Autor: Zhang S; Sumei Zhang, Department of Radiotherapy, Binzhou People's Hospital, Shandong, 256610, China., Zhao S; Shufen Zhao, Department of Oncology, Binzhou People's Hospital, Shandong, 256610, China., Fu X; Xinzhen Fu, Department of Equipment, Binzhou People's Hospital, Shandong, 256610, China.

Publikováno v: Pakistan journal of medical sciences [Pak J Med Sci] 2019 Sep-Oct; Vol. 35 (5), pp. 1264-1269.