Výsledky vyhledávání - "Xinying Qian"

Bifunctional Naphtho[2,3-d][1,2,3]triazole-4,9-dione Compounds Exhibit Antitumor Effects In Vitro and In Vivo by Inhibiting Dihydroorotate Dehydrogenase and Inducing Reactive Oxygen Species Production

Autor: Xia Zhou, Xinying Qian, Na Sang, Qiang Chen, Yinglan Zhao, Yue Zhou, Na Su, Zeping Zuo, Yamei Yu, Ting Zeng, Lei Tao, Huan Liu, Youfu Luo, Xiaocong Liu

Publikováno v: Journal of Medicinal Chemistry. 63:7633-7652

Human dihydroorotate dehydrogenase (hDHODH) is an attractive target for cancer therapy. Based on its crystal structure, we designed and synthesized a focused compound library containing the structu...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cf5af2d17130bdd437e397989565b6b0
https://doi.org/10.1021/acs.jmedchem.0c00512

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Lipidomic profiling reveals lipid regulation by a novel LSD1 inhibitor treatment

Autor: Shengyong Yang, Huaqin Zhang, Yan Li, Xiaobo Cen, Yiyun Lin, Xinying Qian, Lei Tao, Yinglan Zhao, Zeping Zuo

Publikováno v: Oncology Reports

Lipid metabolic alterations are associated with cancer progression. Lysine-specific demethylase 1 (LSD1) plays a crucial role in cancer and has become a promising target for cancer therapy. However, the effect of LSD1 on lipid metabolism remains uncl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24c36eb79a06bdf7ff7000ca78ee5024
https://doi.org/10.3892/or.2021.8184

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ZY0511, a novel, potent and selective LSD1 inhibitor, exhibits anticancer activity against solid tumors via the DDIT4/mTOR pathway

Autor: Hu Zhang, Xinying Qian, Shengyong Yang, Zeping Zuo, Yinglan Zhao, Yan Li, Xiaobo Cen, Yiyun Lin, Chunqi Liu, Huaqin Zhang, Hui Jie, Yang Zhou, Zhuoling Li, Lei Tao

Publikováno v: Cancer Letters. 454:179-190

Lysine-specific demethylase1 (LSD1) plays a crucial role in cancer and has become a promising target for cancer therapy. However, the mechanism underlying the role of LSD1 in oncogenesis is poorly understood, and more effective LSD1 inhibitors are ne

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9369dd9efbfda331eec381402c38e986
https://doi.org/10.1016/j.canlet.2019.03.052

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Cocaine modifies brain lipidome in mice

Autor: Zhuoling Li, Jing Hu, Yan Li, Huaqin Zhang, Hui Gu, Yiyun Lin, Wei Guo, Yinglan Zhao, Dandan Li, Xiaobo Cen, Linhong Jiang, Xinying Qian, Wei Xu, Chunqi Liu

Publikováno v: Molecular and Cellular Neuroscience. 85:29-44

Lipids are predominant components of the brain and key regulators for neural structure and function. The neuropsychopharmacological effect of cocaine has been intensively investigated; however, the impact of cocaine on brain lipid profiles is largely

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::064d561706e6c78364e45ccefec322e1
https://doi.org/10.1016/j.mcn.2017.08.004

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1H-NMR-based metabolic profiling of a colorectal cancer CT-26 lung metastasis model in mice

Autor: Xiaoni Shao, Chunting Wang, Zhuoling Li, Jing Hu, Xinying Qian, Huaqin Zhang, Yan Li, Yiyun Lin, Yinglan Zhao, Dandan Li, Pengchi Deng, Chunqi Liu, Hui Jie

Publikováno v: Oncology Reports. 38:3044-3054

Lung metastasis is an important cause for the low 5-year survival rate of colorectal cancer patients. Understanding the metabolic profile of lung metastasis of colorectal cancer is important for developing molecular diagnostic and therapeutic approac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50d1eb8b88eaf9dfe665bbd2265c920d
https://doi.org/10.3892/or.2017.5954

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Design and biological evaluation of tetrahydropyridine derivatives as novel human GPR119 agonists

Autor: Xiaocong Liu, Hui Jie, Yan Li, Miaomiao Chen, Yinglan Zhao, Zeping Zuo, Xinying Qian, Pengchi Deng, Xiaobo Cen, Yongmei Xie, Xia Zhou, Jiawei Xiang, Chunqi Liu, Xiaoni Shao

Publikováno v: Bioorganicmedicinal chemistry letters. 30(4)

A series of novel tetrahydropyridine derivatives were prepared and evaluated using cell-based measurements. Systematic optimization of general structure G-1 led to the identification of compound 35 (EC50 = 4.9 nM) and 37 (EC50 = 8.8 nM) with high GPR

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f730e7b89558b26a47548460b68a6d45
https://pubmed.ncbi.nlm.nih.gov/31898998

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Reprogramming of lipid metabolism in cancer-associated fibroblasts potentiates migration of colorectal cancer cells

Autor: Na Sang, Xiaowei Yang, Huaqin Zhang, Xinying Qian, Yiyun Lin, Chunqi Liu, Xiao Du, Xiaobo Cen, Yinglan Zhao, Jin Gong, Jiamei Zhang, Zhong Cheng, Yuanyuan Xiao, Liang Wang

Publikováno v: Cell Death & Disease
Cell Death and Disease, Vol 11, Iss 4, Pp 1-15 (2020)

Metabolic interaction between cancer-associated fibroblasts (CAFs) and colorectal cancer (CRC) cells plays a major role in CRC progression. However, little is known about lipid alternations in CAFs and how these metabolic reprogramming affect CRC cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc85b5b7829e6049ff6a60cb8b7c02ba
https://pubmed.ncbi.nlm.nih.gov/32327627

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