Zobrazeno 1 - 10
of 397
pro vyhledávání: '"Xinxin Ding"'
Publikováno v:
Journal of Medical Internet Research, Vol 26, p e55847 (2024)
BackgroundWhile large language models (LLMs) such as ChatGPT and Google Bard have shown significant promise in various fields, their broader impact on enhancing patient health care access and quality, particularly in specialized domains such as oral
Externí odkaz:
https://doaj.org/article/570601d872e94f8d9975818ac0e18e3a
Autor:
Yurong Lai, Xiaoyan Chu, Li Di, Wei Gao, Yingying Guo, Xingrong Liu, Chuang Lu, Jialin Mao, Hong Shen, Huaping Tang, Cindy Q. Xia, Lei Zhang, Xinxin Ding
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 12, Iss 6, Pp 2751-2777 (2022)
Drug metabolism and pharmacokinetics (DMPK) is an important branch of pharmaceutical sciences. The nature of ADME (absorption, distribution, metabolism, excretion) and PK (pharmacokinetics) inquiries during drug discovery and development has evolved
Externí odkaz:
https://doaj.org/article/ad5b8e44c4ee4e82a20397fba8e3e93f
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 12, Pp 3820-3835 (2021)
Pyrrolizidine alkaloids (PAs) are the most common phytotoxins with documented human hepatotoxicity. PAs require metabolic activation by cytochromes P450 to generate toxic intermediates which bind to proteins and form protein adducts, thereby causing
Externí odkaz:
https://doaj.org/article/8ec1c36ad15b4605abe5aba153fe290d
Autor:
Aryatara Shakya, Matthew Dodson, Janick F. Artiola, Monica Ramirez-Andreotta, Robert A. Root, Xinxin Ding, Jon Chorover, Raina M. Maier
Publikováno v:
Water, Vol 15, Iss 9, p 1751 (2023)
Arsenic is ubiquitous in soil and water environments and is consistently at the top of the Agency for Toxic Substances Disease Registry (ATSDR) substance priority list. It has been shown to induce toxicity even at low levels of exposure. One of the m
Externí odkaz:
https://doaj.org/article/5059a29eab1c4b68b7b1887e617b4588
Publikováno v:
Foods, Vol 12, Iss 5, p 951 (2023)
This study examined the effect of calcium hydroxide (Ca(OH)2, 0.6%, w/w) on structural, physicochemical and in vitro digestibility properties of the complexed system of Tartary buckwheat starch (TBS) and rutin (10%, w/w). The pre-gelatinization and c
Externí odkaz:
https://doaj.org/article/97fe266685d54f0692137ac967b6947f
Autor:
Xinxin Ding, Xiaoguo Zhang, Julio Paez-Valencia, Fionn McLoughlin, Francisca C. Reyes, Kengo Morohashi, Erich Grotewold, Richard D. Vierstra, Marisa S. Otegui
Publikováno v:
Frontiers in Plant Science, Vol 13 (2022)
The molecular machinery orchestrating microautophagy, whereby eukaryotic cells sequester autophagic cargo by direct invagination of the vacuolar/lysosomal membrane, is still largely unknown, especially in plants. Here, we demonstrate microautophagy o
Externí odkaz:
https://doaj.org/article/342175b883ff42c2bee7fc58b7cba18b
Autor:
Andrea Leonardi, Nataliia Kovalchuk, Lei Yin, Lauren Endres, Sara Evke, Steven Nevins, Samuel Martin, Peter C. Dedon, J. Andres Melendez, Laura Van Winkle, Qing-Yu Zhang, Xinxin Ding, Thomas J. Begley
Publikováno v:
Epigenetics, Vol 15, Iss 10, Pp 1121-1138 (2020)
The epitranscriptomic writer Alkylation Repair Homolog 8 (ALKBH8) is a transfer RNA (tRNA) methyltransferase that modifies the wobble uridine of selenocysteine tRNA to promote the specialized translation of selenoproteins. Using Alkbh8 deficient (Alk
Externí odkaz:
https://doaj.org/article/d464ab1c8bef4c1bb173527d6328c626
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 10, Iss 1, Pp 123-135 (2020)
We examined the impact of gut inflammation on the expression of cytochrome P450 (P450) and other biotransformation genes in male mice using a dextran sulfate sodium (DSS)-induced colitis model. Several P450 isoforms, including CYP1A, CYP2B, CYP2C, an
Externí odkaz:
https://doaj.org/article/2dab75d104b9461693a2ec92ff9815b3
Autor:
Pengfei Liu, Matthew Dodson, Hui Li, Cody J. Schmidlin, Aryatara Shakya, Yongyi Wei, Joe G.N. Garcia, Eli Chapman, Pawel R. Kiela, Qing-Yu Zhang, Eileen White, Xinxin Ding, Aikseng Ooi, Donna D. Zhang
Publikováno v:
Molecular Metabolism, Vol 51, Iss , Pp 101243- (2021)
Objective: NRF2, a transcription factor that regulates cellular redox and metabolic homeostasis, plays a dual role in human disease. While it is well known that canonical intermittent NRF2 activation protects against diabetes-induced tissue damage, l
Externí odkaz:
https://doaj.org/article/9b6867c4cff24e0b97a6adf722e6305c
Publikováno v:
Applied Sciences, Vol 12, Iss 20, p 10457 (2022)
Aimed at improving the production efficiency of tetrahedron-like pervious frames for the river revetment, self-compacting steel fiber reinforced concrete (SFRC) was applied to strengthen the tensile resistance of concrete to remove conventional steel
Externí odkaz:
https://doaj.org/article/d496314ac45f4b5091dfa142af9e3cba