Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Xinxian, Deng"'
Autor:
Giancarlo Bonora, Vijay Ramani, Ritambhara Singh, He Fang, Dana L. Jackson, Sanjay Srivatsan, Ruolan Qiu, Choli Lee, Cole Trapnell, Jay Shendure, Zhijun Duan, Xinxian Deng, William S. Noble, Christine M. Disteche
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-36 (2021)
Abstract Background Mammalian development is associated with extensive changes in gene expression, chromatin accessibility, and nuclear structure. Here, we follow such changes associated with mouse embryonic stem cell differentiation and X inactivati
Externí odkaz:
https://doaj.org/article/2c9de6e28d644156acdf2680b105da84
Autor:
He Fang, Giancarlo Bonora, Jordan P. Lewandowski, Jitendra Thakur, Galina N. Filippova, Steven Henikoff, Jay Shendure, Zhijun Duan, John L. Rinn, Xinxian Deng, William S. Noble, Christine M. Disteche
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Firre encodes a lncRNA involved in nuclear organization in mammals. Here, the authors find that allelic deletion of Firre on the active X chromosome (Xa) results in dose-dependent loss of histone H3K27me3 on the inactive X chromosome (Xi), along with
Externí odkaz:
https://doaj.org/article/f2fa1372c67040d5a7985930598deed0
Autor:
Xinxian Deng, He Fang, Asha Pathak, Angela M. Zou, Whitney Neufeld-Kaiser, Emily A. Malouf, Richard A. Failor, Fuki M. Hisama, Yajuan J. Liu
Publikováno v:
Frontiers in Genetics, Vol 11 (2020)
BackgroundHypergonadotropic hypogonadism (HH) is characterized by low sex steroid levels and secondarily elevated gonadotropin levels with either congenital or acquired etiology. Genetic factors leading to HH have yet to be fully elucidated.MethodsHe
Externí odkaz:
https://doaj.org/article/3dc4d9f2c90a4f2f956fd8f281eb4c74
Autor:
He Fang, Ana R. Tronco, Giancarlo Bonora, Truong Nguyen, Jitendra Thakur, Joel B. Berletch, Galina N. Filippova, Steven Henikoff, Jay Shendure, William S. Noble, Christine M. Disteche, Xinxian Deng
Publikováno v:
bioRxiv
BackgroundThe number and escape levels of genes that escape X chromosome inactivation (XCI) in female somatic cells vary among tissues and cell types, potentially contributing to specific sex differences. Here we investigate the role of CTCF, a maste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cea792242ecf59a813af98b444a56935
https://europepmc.org/articles/PMC10187265/
https://europepmc.org/articles/PMC10187265/
Autor:
Chengxiang Qiu, Beth K. Martin, Ian C. Welsh, Riza M. Daza, Truc-Mai Le, Xingfan Huang, Eva K. Nichols, Megan L. Taylor, Olivia Fulton, Diana R. O’Day, Anne Roshella Gomes, Saskia Ilcisin, Sanjay Srivatsan, Xinxian Deng, Christine M. Disteche, William Stafford Noble, Nobuhiko Hamazaki, Cecilia B. Moens, David Kimelman, Junyue Cao, Alexander F. Schier, Malte Spielmann, Stephen A. Murray, Cole Trapnell, Jay Shendure
The house mouse,Mus musculus, is an exceptional model system, combining genetic tractability with close homology to human biology. Gestation in mouse development lasts just under three weeks, a period during which its genome orchestrates the astonish
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6adc05866263a01873e739f8b89c8a3e
https://doi.org/10.1101/2023.04.05.535726
https://doi.org/10.1101/2023.04.05.535726
Autor:
Ashley F. Tsue, Evan E. Kania, Diana Q. Lei, Rose Fields, Christopher D. McGann, Elliot Hershberg, Xinxian Deng, Maryanne Kihiu, Shao-En Ong, Christine M. Disteche, Sita Kugel, Brian J. Beliveau, Devin K. Schweppe, David M. Shechner
Publikováno v:
bioRxiv
Throughout biology, RNA molecules form complex networks of molecular interactions that are central to their function, but remain challenging to investigate. Here, we introduce Oligonucleotide-mediated proximity-interactome MAPping (O-MAP), a straight
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6883d23e364b652de865445cd891798e
https://europepmc.org/articles/PMC9882335/
https://europepmc.org/articles/PMC9882335/
Autor:
Joel B. Berletch, Wenxiu Ma, Fan Yang, Jay Shendure, William S. Noble, Christine M. Disteche, Xinxian Deng
Publikováno v:
Data in Brief, Vol 5, Iss C, Pp 761-769 (2015)
X chromosome inactivation (XCI) is a female-specific mechanism that serves to balance gene dosage between the sexes whereby one X chromosome in females is inactivated during early development. Despite this silencing, a small portion of genes escape i
Externí odkaz:
https://doaj.org/article/94343594b6494fc3b20a2670c75002bf
Publikováno v:
Hum Mol Genet
The gene content of the X and Y chromosomes has dramatically diverged during evolution. The ensuing dosage imbalance within the genome of males and females has led to unique chromosome-wide regulatory mechanisms with significant and sex-specific impa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f328f0ccc184209b184bb62211e5030
https://doi.org/10.1093/hmg/ddab221
https://doi.org/10.1093/hmg/ddab221
Publikováno v:
Genes; Volume 14; Issue 4; Pages: 852
The X-linked SMC1A gene encodes a core subunit of the cohesin complex that plays a pivotal role in genome organization and gene regulation. Pathogenic variants in SMC1A are often dominant-negative and cause Cornelia de Lange syndrome (CdLS) with grow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5de50366a139a2250dcb6d2287c77bb1
https://doi.org/10.3390/genes14040852
https://doi.org/10.3390/genes14040852
Autor:
David Shechner, Ashley Tsue, Evan Kania, Rose Fields, Xinxian Deng, Shao-En Ong, Christine Disteche, Brian Beliveau, Devin Schweppe
Publikováno v:
Journal of Biological Chemistry. 299:104248
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d74b00bc86809c00d6a5c07b5f180f4a
https://doi.org/10.1016/j.jbc.2023.104248
https://doi.org/10.1016/j.jbc.2023.104248