Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Xinuo Li"'
Autor:
Xinuo Li, Yuan Sun, Zheng Zhou, Jinran Li, Sai Liu, Long Chen, Yiting Shi, Min Wang, Zheying Zhu, Guangji Wang, Qiulun Lu
Publikováno v:
Advanced Science, Vol 11, Iss 18, Pp n/a-n/a (2024)
Abstract Alzheimer's disease (AD) is a pressing concern in neurodegenerative research. To address the challenges in AD drug development, especially those targeting Aβ, this study uses deep learning and a pharmacological approach to elucidate the pot
Externí odkaz:
https://doaj.org/article/8933bc364c06427d88ab817316ecdf50
Autor:
Xinuo Li, Dehong Shen, Zheying Zhu, Dayin Lyu, Chang He, Yuan Sun, Jinran Li, Qiulun Lu, Guangji Wang
Publikováno v:
Redox Biology, Vol 64, Iss , Pp 102785- (2023)
There are no effective therapeutic targets or strategies that simultaneously inhibit tumour growth and promote cardiac function recovery. Here, we analyzed targets for cancer treatments and cardiac repair, with demethylation emerging as a common fact
Externí odkaz:
https://doaj.org/article/c0173821e7fd4037a4e4f4f1bf3a7135
Autor:
Yuan Sun, Jinran Li, Nan A, Zhaoxing Li, Wenyi Zhong, Long Chen, Sai Liu, Bocheng Zhang, Zheying Zhu, Xinuo Li
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Alzheimer’s disease (AD) is a progressive neurodegenerative disease and linked to abnormal deposition of amyloid-β (Aβ), neurofibrillary tangles (NFTs), synaptic dysfunction, and neuroinflammation. Despite significant progress in unravelling the
Externí odkaz:
https://doaj.org/article/0ed65f32f372465489fcd132f533f6ed
Publikováno v:
Cells, Vol 12, Iss 23, p 2672 (2023)
Alzheimer’s disease (AD) is a leading neurodegenerative condition causing cognitive and memory decline. With small-molecule drugs targeting Aβ proving ineffective, alternative targets are urgently needed. Neuroinflammation, which is central to AD
Externí odkaz:
https://doaj.org/article/2dfa9d498d4c4e809e27190d5769616b
Publikováno v:
Cells, Vol 12, Iss 19, p 2348 (2023)
Alzheimer’s disease (AD), an age-related degenerative disorder, is characterized by β-amyloid deposition, abnormal phosphorylation of tau proteins, synaptic dysfunction, neuroinflammation, and oxidative stress. Despite extensive research, there ar
Externí odkaz:
https://doaj.org/article/2be76e9f5f4247349961a78135e76dfb
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 15, p 11976 (2023)
Alzheimer’s disease (AD) is a prevalent neurodegenerative disorder, hallmarked by the accumulation of amyloid-β (Aβ) plaques and neurofibrillary tangles. Due to the uncertainty of the pathogenesis of AD, strategies aimed at suppressing neuroinfla
Externí odkaz:
https://doaj.org/article/6582aa853bec4848851b7b7120dc20a1
Autor:
Giuseppe Uras, Xinuo Li, Alessia Manca, Antonella Pantaleo, Marco Bo, Jinyi Xu, Stephanie Allen, Zheying Zhu
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 23, p 14794 (2022)
Alzheimer’s disease (AD) is characterized by an initial accumulation of amyloid plaques and neurofibrillary tangles, along with the depletion of cholinergic markers. The currently available therapies for AD do not present any disease-modifying effe
Externí odkaz:
https://doaj.org/article/fd3fd6f14e44467d91e3159a9166d6c1
Publikováno v:
Cells, Vol 11, Iss 12, p 1925 (2022)
Alzheimer’s disease (AD) is the most common form of dementia, affecting more than 50 million people worldwide with an estimated increase to 139 million people by 2050. The exact pathogenic mechanisms of AD remain elusive, resulting in the fact that
Externí odkaz:
https://doaj.org/article/92bd4d15486f4ce08f00662dfc254bd9
Autor:
Xinnan Li, Tiantian Li, Pengfei Zhang, Xinuo Li, Li Lu, Yuan Sun, Bocheng Zhang, Stephanie Allen, Lisa White, James Phillips, Zheying Zhu, Hequan Yao, Jinyi Xu
Publikováno v:
European Journal of Medicinal Chemistry. 244:114841
Based on the multitarget strategy, a series of novel clioquinol-1-benzyl-1,2,3,6-tetrahydropyridine hybrids were identified for the potential treatment of Alzheimer's disease (AD). Biological evaluation in vitro revealed that these hybrids exhibited
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4a29faf6dcf982a787f68065b1f127b
https://doi.org/10.1016/j.ejmech.2022.114841
https://doi.org/10.1016/j.ejmech.2022.114841
Development of Alectinib-Based PROTACs as Novel Potent Degraders of Anaplastic Lymphoma Kinase (ALK)
Autor:
Jinyi Xu, Xinuo Li, Wenyi Zhong, Jingjie Zhu, Feiyan Zhan, Hong Yao, Sun Yuan, Zhe-Sheng Chen, Xinnan Li, Shaowen Xie, Liu Yulin, Shengtao Xu, Dong-Hua Yang
Publikováno v:
Journal of medicinal chemistry. 64(13)
A series of novel anaplastic lymphoma kinase (ALK) degraders were designed and synthesized based on proteolysis-targeting chimera (PROTAC) technology by linking two alectinib analogs (36 and 37) with pomalidomide through linkers of different lengths
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::185b4dfcaa69c290ec6bf960ec6508e9
https://pubmed.ncbi.nlm.nih.gov/34176264
https://pubmed.ncbi.nlm.nih.gov/34176264