Výsledky vyhledávání - "Xinshan Kang"

Discovery and preliminary structure–activity relationship studies of novel benzotriazine based compounds as Src inhibitors

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 16:5546-5550

We report the discovery and preliminary SAR studies of a series of structurally novel benzotriazine core based small molecules as inhibitors of Src kinase. To the best of our knowledge, benzotriazine template based compounds have not been reported as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77c3a59d9d64cb5d6108ec85b738a7b4
https://doi.org/10.1016/j.bmcl.2006.08.035

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Hierarchical Database Screenings for HIV-1 Reverse Transcriptase Using a Pharmacophore Model, Rigid Docking, Solvation Docking, and MM−PB/SA

Autor: Peter A. Kollman, Junmei Wang, Xinshan Kang, Irwin D. Kuntz

Publikováno v: Journal of Medicinal Chemistry. 48:2432-2444

In this work, an efficient strategy was presented to search drug leads for human immunodeficiency virus type 1 reverse transcriptase (HIV-1 RT) using hierarchical database screenings, which included a pharmacophore model, multiple-conformation rigid

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https://doi.org/10.1021/jm049606e

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Role of Heme in Structural Organization of CytochromecProbed by Semisynthesis

Autor: Xinshan Kang, Jannette Carey

Publikováno v: Biochemistry. 38:15944-15951

The heme prosthetic group of cytochrome c is covalently attached to the protein through thioether bonds to two cysteine side chains. The role of covalent heme attachment to cytochrome c is not understood, and most heme proteins bind the prosthetic gr

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https://doi.org/10.1021/bi9919089

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Structural organization in peptide fragments of cytochrome c by heme binding 1 1Edited by P. E. Wright

Autor: Jannette Carey, Xinshan Kang

Publikováno v: Journal of Molecular Biology. 285:463-468

Prosthetic groups are often important structural organizers of proteins as well as essential functional components. Insertion of prosthetic groups is usually spontaneous, and implies an apoprotein that is partially preorganized to provide a recogniti

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https://doi.org/10.1006/jmbi.1998.2341

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Synthesis and biological evaluation of crown ether fused quinazoline analogues as potent EGFR inhibitors

Autor: Fenlai Tan, Fei Wang, Shaojing Hu, Xinshan Kang, Yinxiang Wang, Lieming Ding, Don Zhang, Yunyan Hu, Wei Long, Guojian Xie, Charles Davis

Publikováno v: Bioorganicmedicinal chemistry letters. 22(19)

Crown ether fused anilinoquinazoline analogues were synthesized as novel epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors. Representative compounds showed potent and selective EGFR inhibitory activities in an in vitro EGFR kinase as

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https://pubmed.ncbi.nlm.nih.gov/22959248

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Inhibitors of ABL and the ABL-T315I mutation

Autor: Elena Dneprovskaia, Daniel L. Lohse, Richard Soll, Andrew McPherson, Chi Ching Mak, John Hood, Boris Klebansky, Richard M. Fine, Joel Renick, Jianguo Cao, Chun P. Chow, Moorthy S. S. Palanki, Glenn Noronha, Ved P. Pathak, Binqi Zeng, Xinshan Kang

Publikováno v: Current topics in medicinal chemistry. 8(10)

Chronic myelogenous leukemia (CML) is a hematological stem cell disorder caused by increased and unregulated growth of myeloid cells in the bone marrow, and the accumulation of excessive white blood cells. Abelson tyrosine kinase (ABL) is a non-recep

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https://pubmed.ncbi.nlm.nih.gov/18673174

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Discovery of 3,3'-(2,4-diaminopteridine-6,7-diyl)diphenol as an isozyme-selective inhibitor of PI3K for the treatment of ischemia reperfusion injury associated with myocardial infarction

Autor: Shiyin Yee, John Doukas, Wolfgang Wrasidlo, Michael D. Martin, Hong Zhu, John Hood, Moorthy S. S. Palanki, Daniel L. Lohse, Glenn Noronha, Richard Soll, Xinshan Kang, Richard M. Fine, Elena Dneprovskaia

Publikováno v: Journal of medicinal chemistry. 50(18)

In studies aimed toward identifying effective and safe inhibitors of kinase signaling cascades that underlie ischemia/reperfusion (I/R) injury, we synthesized a series of pteridines and pyridopyrazines. The design strategy was inspired by the examina

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https://pubmed.ncbi.nlm.nih.gov/17685602

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The design and preliminary structure-activity relationship studies of benzotriazines as potent inhibitors of Abl and Abl-T315I enzymes

Autor: Chi Ching Mak, Richard E. Fine, Andrew McPherson, John Hood, Daniel L. Lohse, Moorthy S. S. Palanki, Xinshan Kang, Colleen Gritzen, Boris Klebansky, Ved P. Pathak, Joel Renick, Richard Soll, Jianguo Cao, Binqi Zeng, Hong Zhu, Glenn Noronha

Publikováno v: Bioorganicmedicinal chemistry letters. 17(21)

We describe the design, synthesis and structure-activity relationship studies in optimizing a series of benzotriazine compounds as potent inhibitors of both Abl and Abl-T315I enzymes. The design includes targeting of an acid functional residue on the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9487248cf8bfc4677744d54717e2e8d8
https://pubmed.ncbi.nlm.nih.gov/17827012

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