Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Xinran Geng"'
Publikováno v:
Cell Reports, Vol 42, Iss 5, Pp 112531- (2023)
Summary: Genomic instability can promote inflammation and tumor development. Previous research revealed an unexpected layer of regulation of genomic instability by a cytoplasmic protein MYO10; however, the underlying mechanism remained unclear. Here,
Externí odkaz:
https://doaj.org/article/6b40777165fc4f1ab69d94c579667f8d
Autor:
Lei Zhang, Xinran Geng, Fangfang Wang, Jinshan Tang, Yu Ichida, Arishya Sharma, Sora Jin, Mingyue Chen, Mingliang Tang, Franklin Mayca Pozo, Wenxiu Wang, Janet Wang, Michal Wozniak, Xiaoxia Guo, Masaru Miyagi, Fulai Jin, Yongjie Xu, Xinsheng Yao, Youwei Zhang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
The 53BP1 protein is well-known for its involvement in double-strand break (DSB) repair. Here the authors show 53BP1 undergoes significant liquid-liquid phase separation (LLPS) to play a role in heterochromatin maintenance and identify distinct domai
Externí odkaz:
https://doaj.org/article/12205ecb810c4c64a97fa7a840c621aa
Autor:
Xiaoxia Song, Zhi Chen, Xue Zhang, Junfeng Xiong, Teng Jiang, Zihan Wang, Xinran Geng, U Kei Cheang
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Magnetic micro/nanorobots attracted much attention in biomedical fields because of their precise movement, manipulation, and targeting abilities. However, there is a lack of research on intelligent micro/nanorobots with stimuli-responsive dr
Externí odkaz:
https://doaj.org/article/985a9e2dfe594091b842b7343cd1cd1d
Autor:
Shanshan Ding, Xingguo Song, Xinran Geng, Lele Liu, Hongxin Ma, Xiujuan Wang, Ling Wei, Li Xie, Xianrang Song
Publikováno v:
Thoracic Cancer, Vol 10, Iss 10, Pp 1973-1983 (2019)
Background Both quantitative and qualitative aspects of plasma cell‐free DNA (plasma cfDNA, pcfDNA) have been well‐studied as potential biomarkers in non‐small cell lung cancer (NSCLC). Accumulating evidence has proven that saliva also has the
Externí odkaz:
https://doaj.org/article/1f714cf84f5242d9ac9bc090105b5140
Autor:
Xingguo Song, Lisheng Liu, Minghui Chang, Xinran Geng, Xingwu Wang, Weijun Wang, Thomas C. Chen, Li Xie, Xianrang Song
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 38, Iss 1, Pp 1-15 (2019)
Abstract Background Temozolomide-perillyl alcohol conjugate (NEO212), a novel temozolomide (TMZ) analog, was previously reported to exert its anti-cancer effect in non-small cell lung cancer (NSCLC), and human nasopharyngeal carcinoma (NPC), etc.. In
Externí odkaz:
https://doaj.org/article/3807ad53c338401a89bd64dfd85db3b2
Autor:
Fangfang Wang, Franklin Mayca Pozo, Danmei Tian, Xinran Geng, Xinsheng Yao, Youwei Zhang, Jinshan Tang
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Externí odkaz:
https://doaj.org/article/232e2c3e6c6241b195eb499f1fe693df
Autor:
Fangfang Wang, Franklin Mayca Pozo, Danmei Tian, Xinran Geng, Xinsheng Yao, Youwei Zhang, Jinshan Tang
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Shikonin is a natural naphthoquinone compound and has demonstrated potent anti-cancer activities; however, the underlying molecular mechanisms remained elusive. Here we report that Shikonin inhibited the growth of a wide range of human cancer cell li
Externí odkaz:
https://doaj.org/article/98cdc45294c840fe9e6249602c419b83
Autor:
Lei Zhang, Xinran Geng, Fangfang Wang, Jinshan Tang, Yu Ichida, Arishya Sharma, Sora Jin, Mingyue Chen, Mingliang Tang, Franklin Mayca Pozo, Wenxiu Wang, Janet Wang, Michal Wozniak, Xiaoxia Guo, Masaru Miyagi, Fulai Jin, Yongjie Xu, Xinsheng Yao, Youwei Zhang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/215d2c59610f47f1ae6e6cd804f8c5a8
Autor:
Minghui Chang, Xingguo Song, Xinran Geng, Xingwu Wang, Weijun Wang, Thomas C. Chen, Li Xie, Xianrang Song
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 37, Iss 1, Pp 1-16 (2018)
Abstract Background Temozolomide-perillyl alcohol conjugate (TMZ-POH), a novel Temozolomide (TMZ) analog developed based on the conjugation of TMZ and perillyl alcohol (POH), displayed strong anticancer potency in multiple cancer types. In this study
Externí odkaz:
https://doaj.org/article/ef7b212ac6da47e1959b84abf71fd072
Autor:
Niko Moses, Mu Zhang, Jheng-Yu Wu, Chen Hu, Shengyan Xiang, Xinran Geng, Yue Chen, Wenlong Bai, You-Wei Zhang, Gerold Bepler, Xiaohong Mary Zhang
Publikováno v:
Cells, Vol 9, Iss 10, p 2237 (2020)
We have previously discovered that HDAC6 regulates the DNA damage response (DDR) via modulating the homeostasis of a DNA mismatch repair protein, MSH2, through HDAC6’s ubiquitin E3 ligase activity. Here, we have reported HDAC6’s second potential
Externí odkaz:
https://doaj.org/article/9609134495974755a0e6983a9f647176