Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Xinqun Wu"'
Autor:
Annemarie Boleij, Payam Fathi, William Dalton, Ben Park, Xinqun Wu, David Huso, Jawara Allen, Sepideh Besharati, Robert A. Anders, Franck Housseau, Amanda E. Mackenzie, Laura Jenkins, Graeme. Milligan, Shaoguang Wu, Cynthia L. Sears
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Boleij et al. show that G protein-coupled receptor 35 (GPR35) regulates the responses to enterotoxigenic Bacteroides fragilis (ETBF) in colonic epithelial cells. They find that GPR35-deficiency nearly protected mice from ETBF-induced death, suggestin
Externí odkaz:
https://doaj.org/article/2986eba9551643dc8608d3a4c5b5b496
Autor:
Jawara Allen, Axel Rosendahl Huber, Cayetano Pleguezuelos-Manzano, Jens Puschhof, Shaoguang Wu, Xinqun Wu, Charelle Boot, Aurelia Saftien, Heather M. O’Hagan, Hao Wang, Ruben van Boxtel, Hans Clevers, Cynthia L. Sears
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 3 (2022)
ABSTRACT Enterotoxigenic Bacteroides fragilis (ETBF) is consistently found at higher frequency in individuals with sporadic and hereditary colorectal cancer (CRC) and induces tumorigenesis in several mouse models of CRC. However, whether specific mut
Externí odkaz:
https://doaj.org/article/c8b925b4810c4dcabf9cb25d68e6536b
Autor:
Rahwa Taddese, Rian Roelofs, Derk Draper, Xinqun Wu, Shaoguang Wu, Dorine W. Swinkels, Harold Tjalsma, Annemarie Boleij
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)
ObjectiveThe opportunistic pathogen Streptococcus gallolyticus is one of the few intestinal bacteria that has been consistently linked to colorectal cancer (CRC). This study aimed to identify novel S. gallolyticus-induced pathways in colon epithelial
Externí odkaz:
https://doaj.org/article/7faf83399274470ea74eb45cd450e5cf
Autor:
Laxmi Sunuwar, Azra Frkatović, Sodbo Sharapov, Qinchuan Wang, Heather M. Neu, Xinqun Wu, Talin Haritunians, Fengyi Wan, Sarah Michel, Shaoguang Wu, Mark Donowitz, Dermot McGovern, Gordan Lauc, Cynthia Sears, Joanna Melia
Publikováno v:
JCI Insight, Vol 5, Iss 20 (2020)
ZIP8 is a metal transporter with a role in manganese (Mn) homeostasis. A common genetic variant in ZIP8 (rs13107325; A391T) ranks in the top 10 of pleiotropic SNPs identified in GWAS; A391T has associations with an increased risk of schizophrenia, ob
Externí odkaz:
https://doaj.org/article/c8a8d7250ef44726afdebb8c100fb512
Autor:
Cynthia L. Sears, Ken S. Lau, Franck Housseau, Robert J. Coffey, Fengyi Wan, Christian Jobin, Seth T. Walk, Robert A. Anders, Martha J. Shrubsole, Karen Carroll, Patricia Simner, Hua Ding, Shaoguang Wu, Xinqun Wu, Cody N. Heiser, Victoria L. Campodónico, Fuad Mohammad, James R. White, John Michel, Sarah Tomkovich, Christine M. Dejea, Courtney Stevens, Madison McMann, Lana Kim, June L. Chan, Ada J. Tam, Jada C. Domingue, Reece J. Knippel, Nicholas O. Markham, Jie Chen, Julia L. Drewes
Supplementary Figure from Human Colon Cancer–Derived Clostridioides difficile Strains Drive Colonic Tumorigenesis in Mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c36d44bf3f5e625f3e60e16ee8e663e
https://doi.org/10.1158/2159-8290.22541276
https://doi.org/10.1158/2159-8290.22541276
Autor:
Cynthia L. Sears, Ken S. Lau, Franck Housseau, Robert J. Coffey, Fengyi Wan, Christian Jobin, Seth T. Walk, Robert A. Anders, Martha J. Shrubsole, Karen Carroll, Patricia Simner, Hua Ding, Shaoguang Wu, Xinqun Wu, Cody N. Heiser, Victoria L. Campodónico, Fuad Mohammad, James R. White, John Michel, Sarah Tomkovich, Christine M. Dejea, Courtney Stevens, Madison McMann, Lana Kim, June L. Chan, Ada J. Tam, Jada C. Domingue, Reece J. Knippel, Nicholas O. Markham, Jie Chen, Julia L. Drewes
Supplementary Table from Human Colon Cancer–Derived Clostridioides difficile Strains Drive Colonic Tumorigenesis in Mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21f52ae0bbb8bf1acb1a065acc7498c4
https://doi.org/10.1158/2159-8290.22541270
https://doi.org/10.1158/2159-8290.22541270
Autor:
Cynthia L. Sears, Ken S. Lau, Franck Housseau, Robert J. Coffey, Fengyi Wan, Christian Jobin, Seth T. Walk, Robert A. Anders, Martha J. Shrubsole, Karen Carroll, Patricia Simner, Hua Ding, Shaoguang Wu, Xinqun Wu, Cody N. Heiser, Victoria L. Campodónico, Fuad Mohammad, James R. White, John Michel, Sarah Tomkovich, Christine M. Dejea, Courtney Stevens, Madison McMann, Lana Kim, June L. Chan, Ada J. Tam, Jada C. Domingue, Reece J. Knippel, Nicholas O. Markham, Jie Chen, Julia L. Drewes
Defining the complex role of the microbiome in colorectal cancer and the discovery of novel, protumorigenic microbes are areas of active investigation. In the present study, culturing and reassociation experiments revealed that toxigenic strains of C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b75dc57b0b4d711f49b25e207c8a0afb
https://doi.org/10.1158/2159-8290.c.6549596.v1
https://doi.org/10.1158/2159-8290.c.6549596.v1
Autor:
Franck Housseau, Drew M. Pardoll, Cynthia L. Sears, Jaime L. Wolfe, David L. Huso, Shaoguang Wu, Xinqun Wu, Hongni Fan, Abby L. Geis
Mitigation of IL-17 response to ETBF in absence of Tregs is not restricted to CD4+ (Th17) cells.. B6.Foxp3DTR mice were inoculated with ETBF. Either 150 μl purified sterile H2O or 50 ng/g DT was administered ip on days -2, -1, 1, 3, & 5. Colonic LPL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dbe3d0ff10e84175289b34cec2a1ae3
https://doi.org/10.1158/2159-8290.22529622.v1
https://doi.org/10.1158/2159-8290.22529622.v1
Autor:
Franck Housseau, Drew M. Pardoll, Cynthia L. Sears, Jaime L. Wolfe, David L. Huso, Shaoguang Wu, Xinqun Wu, Hongni Fan, Abby L. Geis
IL-17+ Foxp3+ Tregs infiltrate ETBF-infected colons. Min mice were inoculated with ETBF on day 0. At 10 weeks, colonic LPLs were harvested from colon tumors (left) and adjacent non-tumor colon tissue (right). Cells were stimulated ex vivo, followed b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::405158293b0979bea222e54801b63450
https://doi.org/10.1158/2159-8290.22529619
https://doi.org/10.1158/2159-8290.22529619
Autor:
Cynthia L. Sears, Drew M. Pardoll, David L. Huso, Sara Van Meerbeke, Jamunarani S. Vadivelu, April C. Roslani, Ausama A. Malik, Thevambiga Iyadorai, Jane W. Wanyiri, Sudipto Ganguly, Ada Tam, Kellie N. Smith, Nicolas J. Llosa, Xinqun Wu, Hongni Fan, Elizabeth C. Wick, Shaoguang Wu, Franck Housseau
Supplementary Table S4. Histology scores for CD4Stat3-/- and WT (CD4Stat3+/+) C57BL/6 mice colonized 7 days with ETBF.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2004423fdcb4db7a279af42f1dfc3e7
https://doi.org/10.1158/0008-5472.22409187.v1
https://doi.org/10.1158/0008-5472.22409187.v1