Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Xinming, Tong"'
Autor:
Tom W. Andrew, Lauren S. Koepke, Yuting Wang, Michael Lopez, Holly Steininger, Danielle Struck, Tatiana Boyko, Thomas H. Ambrosi, Xinming Tong, Yuxi Sun, Gunsagar S. Gulati, Matthew P. Murphy, Owen Marecic, Ruth Tevlin, Katharina Schallmoser, Dirk Strunk, Jun Seita, Stuart B. Goodman, Fan Yang, Michael T. Longaker, George P. Yang, Charles K. F. Chan
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/a776296e94634376a7ce55f548ebe8e1
Autor:
Tom W. Andrew, Lauren S. Koepke, Yuting Wang, Michael Lopez, Holly Steininger, Danielle Struck, Tatiana Boyko, Thomas H. Ambrosi, Xinming Tong, Yuxi Sun, Gunsagar S. Gulati, Matthew P. Murphy, Owen Marecic, Ruth Tevlin, Katharina Schallmoser, Dirk Strunk, Jun Seita, Stuart B. Goodman, Fan Yang, Michael T. Longaker, George P. Yang, Charles K. F. Chan
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Abstract Sexually dimorphic tissues are formed by cells that are regulated by sex hormones. While a number of systemic hormones and transcription factors are known to regulate proliferation and differentiation of osteoblasts and osteoclasts, the mech
Externí odkaz:
https://doaj.org/article/0100156a8dab4a50bd34e51aebdcf483
Autor:
Yuxi Sun, Tatiana Boyko, Owen Marecic, Danielle Struck, Randall K. Mann, Tom W. Andrew, Michael Lopez, Xinming Tong, Stuart B. Goodman, Fan Yang, Michael T. Longaker, Charles K. F. Chan, George P. Yang
Publikováno v:
Biomolecules, Vol 13, Iss 8, p 1214 (2023)
Failure to properly form bone or integrate surgical implants can lead to morbidity and additional surgical interventions in a significant proportion of orthopedic surgeries. While the role of skeletal stem cells (SSCs) in bone formation and repair is
Externí odkaz:
https://doaj.org/article/7d8597179e964c4cb89170a7aed4ad0d
Publikováno v:
Tissue Engineering Part A. 28:712-723
Injuries of the bone-to-tendon interface, such as rotator cuff and anterior cruciate ligament tears, are prevalent musculoskeletal injuries, yet effective methods for repair remain elusive. Tissue engineering approaches that use cells and biomaterial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c30348d6cb0400bdfbc367a3bea06ab2
https://doi.org/10.1089/ten.tea.2021.0099
https://doi.org/10.1089/ten.tea.2021.0099
Publikováno v:
APL Bioengineering, Vol 3, Iss 3, Pp 036108-036108-9 (2019)
Type I collagen is the most abundant extracellular matrix protein in the human body and is commonly used as a biochemical ligand for hydrogel substrates to support cell adhesion in mechanotransduction studies. Previous protocols for conjugating col
Externí odkaz:
https://doaj.org/article/64a676f712884ba882a15d93522807cf
Publikováno v:
Advanced healthcare materials. 12(1)
Glioblastoma multiforme (GBM) is the most prevalent and aggressive brain tumor in adults. Hydrogels have been employed as 3D in vitro culture models to elucidate how matrix cues such as stiffness and degradation drive GBM progression and drug respons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18fa0460bd36ae4ec942aaa224584f75
https://pubmed.ncbi.nlm.nih.gov/36239185
https://pubmed.ncbi.nlm.nih.gov/36239185
Autor:
Xinming Tong, Matthew P. Murphy, Thomas H. Ambrosi, Norma Neff, Owen Marecic, Malachia Y. Hoover, Fan Yang, Maurizio Morri, Debashis Sahoo, Michael T. Longaker, Yuting Wang, Rachel E. Brewer, Holly Steininger, Lauren S. Koepke, Shamik Mascharak, Eun Young Seo, Irving L. Weissman, Charles Chan, Oyinkansola Ajanaku, Michael Lopez, Gunsagar S. Gulati, Adrian McArdle, Jan Sokol, Jun Seita, Rahul Sinha, Ruth Tevlin, Stephanie D. Conley, Laura Lu
Publikováno v:
Nature, vol 597, iss 7875
Nature
Nature
Loss of skeletal integrity during ageing and disease is associated with an imbalance in the opposing actions of osteoblasts and osteoclasts1. Here we show that intrinsic ageing of skeletal stem cells (SSCs)2 in mice alters signalling in the bone marr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2609fe557a9fd7c0c82562917e6c7dd
https://doi.org/10.1038/s41586-021-03795-7
https://doi.org/10.1038/s41586-021-03795-7
Autor:
Thomas H. Ambrosi, Owen Marecic, Liming Zhao, Benjamin Levi, Marcin P. Walkiewicz, Michael T. Lopez, Yuting Wang, Charles Chan, Ryan C. Ransom, Xinming Tong, Matthew P. Murphy, Holly Steininger, Lauren S. Koepke, Stuart B. Goodman, Gunsagar S. Gulati, Michael T. Longaker, Derrick C. Wan, Malachia Y. Hoover, Natalina Quarto, Irving L. Weissman, Fan Yang
Publikováno v:
Nature Medicine. 26:1583-1592
Osteoarthritis (OA) is a degenerative disease resulting in irreversible, progressive destruction of articular cartilage1. The etiology of OA is complex and involves a variety of factors, including genetic predisposition, acute injury and chronic infl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::462b5e6694b70e80e988ffc94f47e391
https://doi.org/10.1038/s41591-020-1013-2
https://doi.org/10.1038/s41591-020-1013-2
Autor:
Danial Barati, Claire Rhee, Tzuhua Lin, Fan Yang, Ejun Huang, Ning Zhang, Yusuke Kohno, Stefan Zwingenberger, Monica Romero-Lopez, Zhenyu Yao, Masaya Ueno, Stuart B. Goodman, Bogdan Conrad, Takeshi Utsunomiya, Chi-Wen Lo, Masahiro Maruyama, Xinming Tong
Publikováno v:
J Biomed Mater Res A
Mesenchymal stem cell (MSC)-based therapy is a promising strategy for bone repair. Furthermore, the innate immune system, and specifically macrophages, plays a crucial role in the differentiation and activation of MSCs. The anti-inflammatory cytokine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aed2e5592a6df2eabc980b8b98ddc7dc
https://doi.org/10.1002/jbm.a.36982
https://doi.org/10.1002/jbm.a.36982
Publikováno v:
Theranostics
Rationale: Injectable matrices are highly desirable for stem cell delivery. Previous research has highlighted the benefit of scaffold macroporosity in enhancing stem cell survival and bone regeneration in vivo. However, there remains a lack of inject
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62d062c0bc634b69bc66eaffda114bcd
https://doi.org/10.7150/thno.41096
https://doi.org/10.7150/thno.41096