Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Xinmin Simon Xie"'
Autor:
Medha J. Gunaratna, Duy H. Hua, Bende Zou, Conrado Pascual, William Cao, Man Zhang, Sahani Weerasekara, Thi D. T. Nguyen, Kui Xiao, Xinmin Simon Xie
Publikováno v:
ARKIVOC, Vol 2019, Iss 3, Pp 22-39 (2019)
Externí odkaz:
https://doaj.org/article/50175da45b5a4384a6deacf74e35d5b3
Publikováno v:
Comprehensive Psychoneuroendocrinology, Vol 11, Iss , Pp 100143- (2022)
Prenatal exposure to drugs of abuse results in neonatal abstinence syndrome (NAS). NAS causes significant morbidity and is associated with costly and lengthy hospitalization. Current pharmacotherapy is suboptimal with no FDA approved treatments. We e
Externí odkaz:
https://doaj.org/article/fb1e39e314c44667a88275c541c954fe
Autor:
Bende Zou, Kui Xiao, Thi D.T. Nguyen, Xinmin Simon Xie, Sahani Weerasekara, Duy H. Hua, Medha J. Gunaratna, Conrado Pascual, Man Zhang, William S. Cao
Publikováno v:
ARKIVOC, Vol 2019, Iss 3, Pp 22-39 (2019)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::355c97a8b722b7815bdeb5d4c0f1a02c
https://doi.org/10.24820/ark.5550190.p010.752
https://doi.org/10.24820/ark.5550190.p010.752
Autor:
Serkan Koldas, Sahani Weerasekara, Duy H. Hua, Medha J. Gunaratna, Xinmin Simon Xie, William S. Cao, Bende Zou, Man Zhang, Conrado Pascual, Zongbo Tong, Thi D.T. Nguyen
Publikováno v:
Heterocycles
Neuropathic pain, epilepsy, insomnia, and tremor disorder may arrive from an increase of intracellular Ca(2+) concentration through a dysfunction of T-type Ca(2+) channels. Thus, T-type calcium channels could be a target in drug discovery for the tre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e303d97f1b3d3d381654e02fd5ad88ea
https://pubmed.ncbi.nlm.nih.gov/32773946
https://pubmed.ncbi.nlm.nih.gov/32773946
Autor:
Lee-Way Jin, Xinmin Simon Xie, Conrado Pascual, Man Zhang, Jacopo Di Lucente, William S. Cao, Sahani Weerasekara, Bende Zou, Izumi Maezawa, Duy H. Hua
Publikováno v:
Journal of Alzheimer's Disease
Journal of Alzheimer's disease : JAD, vol 58, iss 2
Journal of Alzheimer's disease : JAD, vol 58, iss 2
There is an urgent unmet need for new therapeutics for Alzheimer's disease (AD), the most common cause of dementia in the elderly. Therapeutic approaches targeting amyloid-β (Aβ) and its downstream toxicities have become major strategies in AD drug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9aebdaf684f8c36557a63ffcae8b115d
http://europepmc.org/articles/PMC5438482
http://europepmc.org/articles/PMC5438482
Autor:
Zhiwei Guan, Kui Xiao, Xinmin Simon Xie, Julian Xie, Jidong Fang, Jingxi Zhang, C. David Weaver, Bende Zou, Conrado Pascual, William S. Cao, Craig W. Lindsley, Frank Kayser, James Xie
Publikováno v:
Sleep. 42
STUDY OBJECTIVES: A major challenge in treating insomnia is to find effective medicines with fewer side effects. Activation of G-protein-gated inward rectifying K(+) channels (GIRKs) by GABA(B) agonists baclofen or γ-hydroxybutyric acid (GHB) promot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec1660ad1f5c6f54799d789632de9623
https://doi.org/10.1093/sleep/zsy244
https://doi.org/10.1093/sleep/zsy244
Autor:
John Desper, Serkan Koldas, Philine Wangemann, Jianyu Lu, Angelo Aguilar, Aibin Shi, Xinmin Simon Xie, Bende Zou, Weier Bao, Duy H. Hua
Publikováno v:
Bioorganic & Medicinal Chemistry. 23:5985-5998
A class of tetracyclic terpenes was synthesized and evaluated for antagonistic activity of endothelin-1 (ET-1) induced vasoconstriction and inhibitory activity of voltage-activated Ca2+ channels. Three repeated Robinson annulation reactions were util
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f16437ee2104d4d9840e25114df584f
https://doi.org/10.1016/j.bmc.2015.06.055
https://doi.org/10.1016/j.bmc.2015.06.055
Autor:
Gloria Brunori, Jinhua Wu, Lawrence Toll, Daniela Mercatelli, Xinmin Simon Xie, Brigitte L. Kieffer, Akihiko Ozawa, Grégory Scherrer, Andrea Cippitelli, Bende Zou, Melissa Williams, Nurulain T. Zaveri, Sarah A. Low
Publikováno v:
The Journal of Neuroscience. 35:11682-11693
The nociceptin/orphanin FQ (NOP) receptor, the fourth member of the opioid receptor family, is involved in many processes common to the opioid receptors including pain and drug abuse. To better characterize receptor location and trafficking, knock-in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1f12d1425770198298f1b6e66d6856b
https://doi.org/10.1523/jneurosci.5122-14.2015
https://doi.org/10.1523/jneurosci.5122-14.2015
Autor:
Roberto Ciccocioppo, Jinhua Wu, Daniela Mercatelli, Jennifer Schoch, Dennis Yasuda, Xinmin Simon Xie, Taline V. Khroyan, Conrado Pascual, Kelly A. Gaiolini, Andrea Cippitelli, Nurulain T. Zaveri, Alejandra Ramirez, Michelle Gorman, Lawrence Toll
Publikováno v:
British Journal of Pharmacology. 172:1834-1845
Background and Purpose The α3β4 subtype of nicotinic acetylcholine receptors (nAChRs) has been implicated in mediating nicotine reinforcement processes. AT-1001 has been recently described as a high-affinity and selective α3β4 nAChR antagonist th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c61a96bc0fae7078b0ee3fa5dd51faa
https://doi.org/10.1111/bph.13034
https://doi.org/10.1111/bph.13034
Autor:
Dong Feng Chen, Xinmin Simon Xie, Cong Shi, Xuedong Yuan, Gang Luo, Kin-Sang Cho, Karen Chang
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Optomotor response/reflex (OMR) assays are emerging as a powerful and versatile tool for phenotypic study and new drug discovery for eye and brain disorders. Yet efficient OMR assessment for visual performance in mice remains a challenge. Existing OM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::647c394c9135609bfc82f70c3b29b365
https://pubmed.ncbi.nlm.nih.gov/29946119
https://pubmed.ncbi.nlm.nih.gov/29946119