Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Xinmei Wen"'
Autor:
Chen Zhang, Fei Wang, Zheng Long, Jia Yang, Yi Ren, Qingfeng Ma, Jiajian Li, Xinmei Wen, Lijun Wang, Yuwei Da, Maigeng Zhou, Peng Yin, Junwei Hao
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 10, Iss 7, Pp 1095-1105 (2023)
Abstract Objective As a potentially life‐threatening condition, myasthenia gravis (MG) has limited epidemiological studies on mortality. We aim to provide demographic distribution, geographical variation, and temporal trend of MG‐related mortalit
Externí odkaz:
https://doaj.org/article/8213ecc678a1461abe0de934838a3729
Publikováno v:
Journal of Medical Internet Research, Vol 25, p e46621 (2023)
BackgroundThe swift shift toward internet hospitals has relied on the willingness of medical practitioners to embrace new systems and workflows. Low engagement or acceptance by medical practitioners leads to difficulties in patient access. However, f
Externí odkaz:
https://doaj.org/article/2d1573557cf04144b054cfb3aedb527b
Autor:
Brandie Morris Verdone, Maria Elena Cicardi, Xinmei Wen, Sindhu Sriramoji, Katelyn Russell, Shashirekha S. Markandaiah, Brigid K. Jensen, Karthik Krishnamurthy, Aaron R. Haeusler, Piera Pasinelli, Davide Trotti
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-17 (2022)
Abstract Translation of the hexanucleotide G4C2 expansion associated with C9orf72 amyotrophic lateral sclerosis and frontotemporal dementia (ALS/FTD) produces five different dipeptide repeat protein (DPR) species that can confer toxicity. There is ye
Externí odkaz:
https://doaj.org/article/19ca21d95d3242fdb4694723b5e2de9e
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Background and PurposeTwo clinical trials assessing the steroid-sparing effect of methotrexate (MTX) yielded conflicting results. Our objective was to investigate whether MTX would show a steroid-sparing effect in the treatment of generalized myasthe
Externí odkaz:
https://doaj.org/article/3f53278ab79e458c867fc306bb844fff
Autor:
Brigid K Jensen, Martin H Schuldi, Kevin McAvoy, Katelyn A Russell, Ashley Boehringer, Bridget M Curran, Karthik Krishnamurthy, Xinmei Wen, Thomas Westergard, Le Ma, Aaron R Haeusler, Dieter Edbauer, Piera Pasinelli, Davide Trotti
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 5, Pp 1-26 (2020)
Abstract The most common cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) is an intronic hexanucleotide repeat expansion in the C9orf72 gene. In disease, RNA transcripts containing this expanded region undergo repeat‐a
Externí odkaz:
https://doaj.org/article/2b844e943b33490cb8b38258496834ea
Publikováno v:
Frontiers in Neurology, Vol 13 (2022)
ObjectivePrevious studies have reliably identified iron deposition in the motor cortex as potential pathogenesis of amyotrophic lateral sclerosis (ALS). Here, we intended to investigate iron deposition, gray matter (GM) atrophy, and their association
Externí odkaz:
https://doaj.org/article/d5116af57d0c4af88a4135fd106bab75
Autor:
Xinmei Wen, Wenjia Zhu, Nan L. Xia, Qianwen Li, Li Di, Shu Zhang, Hai Chen, Yan Lu, Min Wang, Min Xu, Suobin Wang, Xin-Ming Shen, Jie Lu, Yuwei Da
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
Amyotrophic lateral sclerosis (ALS) is the most common form of motor neuron disease, characterized by a great variety of both clinical presentations and genetic causes. Previous studies had identified two different missense mutations in SOD1 (p.R116C
Externí odkaz:
https://doaj.org/article/05e392a11dd147c9a190895c52b89503
Repeat‐associated non‐AUG translation in C9orf72‐ALS/FTD is driven by neuronal excitation and stress
Autor:
Thomas Westergard, Kevin McAvoy, Katelyn Russell, Xinmei Wen, Yu Pang, Brandie Morris, Piera Pasinelli, Davide Trotti, Aaron Haeusler
Publikováno v:
EMBO Molecular Medicine, Vol 11, Iss 2, Pp 1-14 (2019)
Abstract Nucleotide repeat expansions (NREs) are prevalent mutations in a multitude of neurodegenerative diseases. Repeat‐associated non‐AUG (RAN) translation of these repeat regions produces mono or dipeptides that contribute to the pathogenesis
Externí odkaz:
https://doaj.org/article/357cba24d5134eb4b3da6cedf90a1fe5
Autor:
Shengyao Su, Qing Liu, Xueping Zhang, Xinmei Wen, Lin Lei, Faxiu Shen, Zhirong Fan, Jianying Duo, Yan Lu, Li Di, Min Wang, Hai Chen, Wenjia Zhu, Min Xu, Suobin Wang, Yuwei Da
Publikováno v:
Therapeutic Advances in Neurological Disorders, Vol 14 (2021)
Background: Intravenous immunoglobulin (IVIG) has been commonly used to treat myasthenia gravis exacerbation, but is still ineffective in nearly 30% of patients. A variable number of tandem repeat (VNTR) polymorphism in the FCGRT gene has been found
Externí odkaz:
https://doaj.org/article/6af98c727fe04cafbdec0974001eb9bd
Autor:
Thomas Westergard, Brigid K. Jensen, Xinmei Wen, Jingli Cai, Elizabeth Kropf, Lorraine Iacovitti, Piera Pasinelli, Davide Trotti
Publikováno v:
Cell Reports, Vol 17, Iss 3, Pp 645-652 (2016)
Aberrant hexanucleotide repeat expansions in C9orf72 are the most common genetic change underlying amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). RNA transcripts containing these expansions undergo repeat-associated non-ATG tr
Externí odkaz:
https://doaj.org/article/2e4fc1c1a2374d1da63375d78adcbdcb