Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Xinjun J. Hou"'
Autor:
Raymond S. Hurst, Mihály Hajós, Dennis J. Hoover, William E. Hoffmann, Nandini Chaturbhai Patel, Christopher L. Shaffer, Xinjun J. Hou, Christopher J. O’Donnell, Dina McGinnis, Jayvardhan Pandit, Eric S. Marr, Randall James Gallaschun, Dianne K. Bryce, John T. Lazzaro, Longfei Xie, Jacob Bradley Schwarz, Fliri Anton F J, Justin L Gazard, Ashley N. Hanks, Renato J. Scialis
Publikováno v:
Journal of Medicinal Chemistry. 56:9180-9191
Positive allosteric modulators ("potentiators") of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors (AMPAR) enhance excitatory neurotransmission and may improve the cognitive deficits associated with various neurological disorde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c56e4065349b607cc298e139b742e784
https://doi.org/10.1021/jm401274b
https://doi.org/10.1021/jm401274b
Autor:
Raymond S. Hurst, Nandini Chaturbhai Patel, Dina McGinnis, Xinjun J. Hou, Mihály Hajós, Dianne K. Bryce, Cheng Chang, Christopher J. O’Donnell, JianHua Liu, William E. Hoffmann, Patricia A. Seymour, Laigao Chen, Renato J. Scialis, Yunjing Wei, Karki Kapil Kumar, R. Scott Obach, Longfei Xie, Jacob Bradley Schwarz, John T. Lazzaro, Kenneth R. Zasadny, Sarah M. Osgood, Christopher J. Schmidt, Christopher L. Shaffer, Jayvardhan Pandit, Susan M. Lotarski, Mark L. Weber
Publikováno v:
Journal of medicinal chemistry. 58(10)
A unique tetrahydrofuran ether class of highly potent α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor potentiators has been identified using rational and structure-based drug design. An acyclic lead compound, containing an ether-linked
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b873a139c6f06eceb7f060be61eb5f9
https://pubmed.ncbi.nlm.nih.gov/25905800
https://pubmed.ncbi.nlm.nih.gov/25905800
Autor:
L. A. K. Pelletier, John H. Tatlock, Xinjun J. Hou, Richard E. Showalter, M. Angelica Linton, J. Ernest Villafranca, Charles R. Kissinger, Anna Tempczyk
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:1007-1012
The design, synthesis, and evaluation of small molecule, in vitro, inhibitors of human calcineurin is described. These ligands were derived from the known nonspecific phosphatase inhibitor endothall, and were modified to enhance binding and selectivi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::56059b2c7decb22fe37b673720f9d274
https://doi.org/10.1016/s0960-894x(97)00141-8
https://doi.org/10.1016/s0960-894x(97)00141-8
Autor:
Anna Tempczyk, Tatlock John H, M. Angelica Linton, Charles R. Kissinger, Laura A. Pelletier, Richard E. Showalter, J. Ernest Villafranca, Xinjun J. Hou
Publikováno v:
Molecular Modeling and Prediction of Bioactivity ISBN: 9781461368571
Calcineurin (Protein Phosphatase 2B, or PP2B) is a Ca2+/calmodulin dependent protein phosphatase which plays critical rules in intracellular signaling processes1–3. An important role of calcineurin is its dephospholation function of NFAT(nuclear fa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c69e358339778e16eae505a9df8d9fe
https://doi.org/10.1007/978-1-4615-4141-7_88
https://doi.org/10.1007/978-1-4615-4141-7_88
