Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Xinjun Hou"'
Autor:
Huixin Chen, Patchara Phuektes, Li Sze Yeo, Yi Hao Wong, Regina Ching Hua Lee, Bowen Yi, Xinjun Hou, Sen Liu, Yu Cai, Justin Jang Hann Chu
Publikováno v:
Journal of Biomedical Science, Vol 31, Iss 1, Pp 1-22 (2024)
Abstract Background Chikungunya virus (CHIKV) has reemerged as a major public health concern, causing chikungunya fever with increasing cases and neurological complications. Methods In the present study, we investigated a low-passage human isolate of
Externí odkaz:
https://doaj.org/article/22766d96dac84a428d369461c6fd589c
Autor:
Heng Zhang, Emma Trueman, Xinjun Hou, De Xian Chew, Lu Deng, Jonathan Liew, Tania Chia, Zhiyong Xi, Cheong Huat Tan, Yu Cai
Publikováno v:
BMC Biology, Vol 21, Iss 1, Pp 1-18 (2023)
Abstract Background Aedes aegypti (Ae. aegypti) is the major vector that transmits many diseases including dengue, Zika, and filariasis in tropical and subtropical regions. Due to the growing resistance to chemical-based insecticides, biological cont
Externí odkaz:
https://doaj.org/article/1617b7654a14490eb3a424c48eca64e6
Autor:
Andrea M. Zuhl, Charles E. Nolan, Michael A. Brodney, Sherry Niessen, Kevin Atchison, Christopher Houle, David A. Karanian, Claude Ambroise, Jeffrey W. Brulet, Elizabeth M. Beck, Shawn D. Doran, Brian T. O’Neill, Christopher W. am Ende, Cheng Chang, Kieran F. Geoghegan, Graham M. West, Joshua C. Judkins, Xinjun Hou, David R. Riddell, Douglas S. Johnson
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Several β-secretase (BACE) inhibitors exhibit unexplained ocular toxicity in preclinical studies. Here the authors generate a clickable photoaffinity probe to interrogate off-targets in cells and animals, and identify inhibition of cathepsin D as a
Externí odkaz:
https://doaj.org/article/5dfe4a29e6af43a49ee6c24207abc513
Autor:
Emma King-Smith, Simon Berritt, Louise Bernier, Xinjun Hou, Jacquelyn Klug-McLeod, Jason Mustakis, Neal Sach, Joseph Tucker, Qingyi Yang, Roger Howard, Alpha Lee
High-throughput experimentation (HTE) has the potential to improve our understanding of organic chemistry by systematically interrogating reactivity across diverse chemical spaces. Notable bottlenecks include few publicly available large-scale datase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fe10aa2abc0085ed30e2d72972a8424
https://doi.org/10.21203/rs.3.rs-2262919/v1
https://doi.org/10.21203/rs.3.rs-2262919/v1
Autor:
Dehong Li, John Tosin Aladejana, Xiaodong Wang, Tingjie Chen, Xinjun Hou, Min Niu, Yongqun Xie, Yves Kouomo Guelifack, Zhenzeng Wu
Publikováno v:
Journal of Industrial and Engineering Chemistry. 98:180-188
Fire safety issues have attracted much attention since they cause enormous loss of lives and properties. In this study, the sustainable aluminophosphate (AP) adhesive is developed as a fire retardant for improving the fire performance of medium-densi
Autor:
Dehong Li, Kouomo Guelifack Yves, Xiaodong Wang, John Tosin Aladejana, Yongqun Xie, Qihua Wei, Wei Wei, Xinjun Hou, Zhenzeng Wu
Publikováno v:
BioResources. 16:1702-1712
An aluminophosphate adhesive was used as the binder in plywood. The hot-pressing parameters of aluminophosphate adhesive-based plywood (APPs) including hot-press temperature (A), time (B), and pressure (C) were optimized using response surface method
Autor:
Renee L. DesJarlais, Sebastian Salentin, Klavs F. Jensen, Tommi S. Jaakkola, Daniel J. Griffin, Daniel Rodriguez Greve, Li Xing, Richard I. Robinson, Justin S. Cisar, Xinjun Hou, Constantine Kreatsoulas, Jeffrey W. Johannes, Andrew Palmer, Christos A. Nicolaou, Juan C. Alvarez, Regina Barzilay, William H. Green, Thomas J. Struble, Connor W. Coley, Ola Engkvist, Brian R. Lahue, Milan Chytil, Scott P. Brown, Scott Alan Frank, Daniel J. Price, Georg Mogk, Miriam Mathea
Publikováno v:
Journal of Medicinal Chemistry
Artificial intelligence and machine learning have demonstrated their potential role in predictive chemistry and synthetic planning of small molecules; there are at least a few reports of companies employing in silico synthetic planning into their ove
Autor:
Bo Feng, Mark A. West, Jennifer L. Liras, Travis T. Wager, Nandini Chaturbhai Patel, Larry M. Tremaine, Jillian G. Johnson, Xinjun Hou
Publikováno v:
Journal of Pharmaceutical Sciences. 108:2476-2483
It is of great challenge to predict human brain penetration for substrates of multidrug resistance protein 1 (MDR1) and breast cancer resistance protein (BCRP), 2 major efflux transporters at blood-brain barrier. Thus, a physiologically based pharmac
Autor:
Jacquelyn Klug-McLeod, Alpha A. Lee, Vishnu Sresht, Qingyi Yang, Xinjun Hou, Christopher Ryan Butler, Peter Bolgar
Publikováno v:
Chemical Communications. 55:12152-12155
Predicting how a complex molecule reacts with different reagents, and how to synthesise complex molecules from simpler starting materials, are fundamental to organic chemistry. We show that an attention-based machine translation model - Molecular Tra
Autor:
Nandini Chaturbhai Patel, Jennifer L. Liras, Patrick Trapa, Mark A. West, Tristan S. Maurer, Bo Feng, Patrick Robert Verhoest, Simone Sciabola, Travis T. Wager, Xinjun Hou
Publikováno v:
ACS chemical neuroscience. 12(6)
One of the objectives within the medicinal chemistry discipline is to design tissue targeting molecules. The objective of tissue specificity can be either to gain drug access to the compartment of interest (e.g., the CNS) for Neuroscience targets or