Zobrazeno 1 - 10
of 155
pro vyhledávání: '"Xinjing Tang"'
Autor:
Changmai Chen, Maocheng Yu, Qing Li, Ying Zhou, Mengting Zhang, Shanyu Cai, Jiaojiao Yu, Zhongnan Huang, Jiaan Liu, Ye Kuang, Xinjing Tang, Wei Chen
Publikováno v:
Advanced Science, Vol 11, Iss 32, Pp n/a-n/a (2024)
Abstract Multidrug resistance (MDR) is a major obstacle limiting the effectiveness of chemotherapy against cancer. The combination strategy of chemotherapeutic agents and siRNA targeting drug efflux has emerged as an effective cancer treatment to ove
Externí odkaz:
https://doaj.org/article/5c847781cd234ccf8c6ac22d33f37ebb
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 33, Iss , Pp 548-558 (2023)
Trigger-activatable antisense oligonucleotides have been widely applied to regulate gene function. Among them, caged cyclic antisense oligonucleotides (cASOs) maintain a specific topology that temporarily inhibits their interaction with target genes.
Externí odkaz:
https://doaj.org/article/aee19b68fa6a43c3b2684a181a16f65f
Publikováno v:
Materials Today Bio, Vol 19, Iss , Pp 100575- (2023)
Androgenetic alopecia is an androgen-dependent skin disorder that commonly affects hair follicle growth and hair loss. Gene therapy that can promote the proliferation and survival of hair follicle cells can be a potential choice for its cure. While t
Externí odkaz:
https://doaj.org/article/d49982b4c4fd4cb4a60299391c275a5f
Publikováno v:
Frontiers in Nutrition, Vol 10 (2023)
To enhance the content of adlay bran soluble dietary fiber (SDF) and improve its functionality, we investigated the influences of steam explosion (SE) on the physicochemical, structural properties, and in vitro hypoglycemic activities of adlay bran S
Externí odkaz:
https://doaj.org/article/67be012b8cdf4995a5a4c6f1abe9ca86
Autor:
Xinyang Zhou, Yufei Pan, Lijia Yu, Jing Wu, Zheng Li, Huantong Li, Zhu Guan, Xinjing Tang, Zhenjun Yang
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 25, Iss , Pp 603-612 (2021)
Small interfering RNAs (siRNAs) are widely studied for their highly specific gene silencing activity. However, obstacles remain to the clinical application of siRNAs. Attaching conjugates to siRNAs can improve their stability and broaden their applic
Externí odkaz:
https://doaj.org/article/4abf48c0a6cc47009712ec6c0ab28b05
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Recently, degrader technologies have attracted increasing interest in the academic field and the pharmaceuticals industry. As one of the degrader technologies, proteolysis-targeting chimeras (PROTACs) have emerged as an attractive pharmaceutical deve
Externí odkaz:
https://doaj.org/article/f97dc3c35e334e15a76e30c7de72da8a
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 21, Iss , Pp 604-613 (2020)
Due to highly enzymatic d-stereoselectivity, l-nucleotides (l-2′-deoxynucleoside 5′-triphosphates [l-dNTPs]) are not natural targets of polymerases. In this study, we synthesized series of l-thymidine (l-T)-modified DNA strands and evaluated the
Externí odkaz:
https://doaj.org/article/8d034e89690b4cf1b175071004224142
Publikováno v:
Molecules, Vol 27, Iss 24, p 8992 (2022)
In most organisms, DNA extension is highly regulated; however, most studies have focused on controlling the initiation of replication, and few have been done to control the regulation of DNA extension. In this study, we adopted a new strategy for azO
Externí odkaz:
https://doaj.org/article/504a2969aa9f48d2bed233518d769d43
Autor:
Dao Lin, Yuhe Kan, Liang Yan, Yongqi Ke, Yang Zhang, Hang Luo, Xinjing Tang, Xiangjun Li, Yujian He, Li Wu
Publikováno v:
iScience, Vol 24, Iss 9, Pp 102977- (2021)
Summary: The effective utility of physiologically active molecules is crucial in numerous biological processes. However, the regulation of enzyme functions through active substances remains challenging at present. Here, glutathione (GSH), produced in
Externí odkaz:
https://doaj.org/article/3b2e170aa99248d38c3ef8527c70f449
Publikováno v:
Molecules, Vol 27, Iss 14, p 4377 (2022)
The temporal activation of siRNA provides a valuable strategy for the regulation of siRNA activity and conditional gene silencing. The bioorthogonal bond-cleavage reaction of benzonorbonadiene and tetrazine is a promising trigger in siRNA temporal ac
Externí odkaz:
https://doaj.org/article/55a63f90809a4552af4da33dccf2e8d9