Contribution of common and rare variants to bipolar disorder susceptibility in extended pedigrees from population isolates

Autor: Jae Hoon Sul, Susan K. Service, Alden Y. Huang, Vasily Ramensky, Sun-Goo Hwang, Terri M. Teshiba, YoungJun Park, Anil P. S. Ori, Zhongyang Zhang, Niamh Mullins, Loes M. Olde Loohuis, Scott C. Fears, Carmen Araya, Xinia Araya, Mitzi Spesny, Julio Bejarano, Margarita Ramirez, Gabriel Castrillón, Juliana Gomez-Makhinson, Maria C. Lopez, Gabriel Montoya, Claudia P. Montoya, Ileana Aldana, Javier I. Escobar, Jorge Ospina-Duque, Barbara Kremeyer, Gabriel Bedoya, Andres Ruiz-Linares, Rita M. Cantor, Julio Molina, Giovanni Coppola, Roel A. Ophoff, Gabriel Macaya, Carlos Lopez-Jaramillo, Victor Reus, Carrie E. Bearden, Chiara Sabatti, Nelson B. Freimer

Publikováno v: Translational Psychiatry, Vol 10, Iss 1, Pp 1-10 (2020)

Abstract Current evidence from case/control studies indicates that genetic risk for psychiatric disorders derives primarily from numerous common variants, each with a small phenotypic impact. The literature describing apparent segregation of bipolar

Externí odkaz: https://doaj.org/article/4087ad12ed6c4838a5079239eefcda6f

Contribution of common and rare variants to bipolar disorder susceptibility in extended pedigrees from population isolates

Autor: Julio Bejarano, Javier I. Escobar, Gabriel Montoya, Andres Ruiz-Linares, Ileana Aldana, Roel A. Ophoff, Jae Hoon Sul, Niamh Mullins, Chiara Sabatti, Margarita Ramirez, Jorge Ospina-Duque, Maria C. Lopez, YoungJun Park, Carmen Araya, Victor I. Reus, Gabriel Castrillón, Carlos López-Jaramillo, Giovanni Coppola, Barbara Kremeyer, Vasily Ramensky, Zhongyang Zhang, Carrie E. Bearden, Alden Y. Huang, Gabriel Bedoya, Xinia Araya, Sun-Goo Hwang, Julio Molina, Rita M. Cantor, Scott C. Fears, Gabriel Macaya, Mitzi Spesny, Anil P.S. Ori, Terri M. Teshiba, Claudia Montoya, Juliana Gomez-Makhinson, Loes M. Olde Loohuis, Nelson B. Freimer

Publikováno v: Translational Psychiatry
Translational Psychiatry, Nature Pub. Group, 2020, 10 (1), ⟨10.1038/s41398-020-0758-1⟩
Translational psychiatry, vol 10, iss 1
Translational Psychiatry, Vol 10, Iss 1, Pp 1-10 (2020)
Translational Psychiatry, 2020, 10 (1), ⟨10.1038/s41398-020-0758-1⟩

Current evidence from case/control studies indicates that genetic risk for psychiatric disorders derives primarily from numerous common variants, each with a small phenotypic impact. The literature describing apparent segregation of bipolar disorder

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a00154fb1e53652bee503cf9c6ebb89b
https://hal.archives-ouvertes.fr/hal-03268999

Genetic contributions to circadian activity rhythm and sleep pattern phenotypes in pedigrees segregating for severe bipolar disorder

Autor: Lucia Pagani, Patricia A. St. Clair, Terri M. Teshiba, Susan K. Service, Scott C. Fears, Carmen Araya, Xinia Araya, Julio Bejarano, Margarita Ramirez, Gabriel Castrillón, Juliana Gomez-Makhinson, Maria C. Lopez, Gabriel Montoya, Claudia P. Montoya, Ileana Aldana, Linda Navarro, Daniel G. Freimer, Brian Safaie, Lap-Woon Keung, Kiefer Greenspan, Katty Chou, Javier I. Escobar, Jorge Ospina-Duque, Barbara Kremeyer, Andres Ruiz-Linares, Rita M. Cantor, Carlos Lopez-Jaramillo, Gabriel Macaya, Julio Molina, Victor I. Reus, Chiara Sabatti, Carrie E. Bearden, Joseph S. Takahashi, Nelson B. Freimer

Publikováno v: Proceedings of the National Academy of Sciences; Volumen 113, Número 6. 2016.
Kérwá
Universidad de Costa Rica
instacron:UCR
Proceedings of the National Academy of Sciences of the United States of America, vol 113, iss 6

Abnormalities in sleep and circadian rhythms are central features of bipolar disorder (BP), often persisting between episodes. We report here, to our knowledge, the first systematic analysis of circadian rhythm activity in pedigrees segregating sever

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fabb1b2fb3e2836a9e7040ba52d2a9f6
https://europepmc.org/articles/PMC4760829/

Convergent linkage evidence from two Latin-American population isolates supports the presence of a susceptibility locus for bipolar disorder in 5q31–34

Autor: Pablo Davanzo, Daniel Ortiz, Carlos Palacio, Constanza Duque, Matthew Levinson, Carmen Araya Ortiz, Guadalupe Polanco, Carlos López, Carol A. Mathews, Andrés Ruiz-Linares, Gabriel J. Restrepo, Magui Ramirez, Barbara Kremeyer, Julio Bejarano, Julio Molina, Damini Jawaheer, Gabriel Bedoya, Nelson B. Freimer, Victor I. Reus, Jorge Vega, María Victoria Parra, Xinia Araya, Jenny García, L. Carvajal, Ileana Aldana, Anna J. Jasinska, Chiara Sabatti, Gabriel Macaya, Eduardo Fournier, Jorge Ospina, Ibi Herzberg

Publikováno v: Human Molecular Genetics. 15:3146-3153

We performed a whole genome microsatellite marker scan in six multiplex families with bipolar (BP) mood disorder ascertained in Antioquia, a historically isolated population from North West Colombia. These families were characterized clinically using

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2096369fdd4adf31e4bc754da4ed457f
https://doi.org/10.1093/hmg/ddl254

Multisystem component phenotypes of bipolar disorder for genetic investigations of extended pedigrees

Autor: Scott C. Fears, Susan K. Service, Barbara Kremeyer, Carmen Araya, Xinia Araya, Julio Bejarano, Margarita Ramirez, Gabriel Castrillón, Juliana Gomez-Franco, Maria C. Lopez, Gabriel Montoya, Patricia Montoya, Ileana Aldana, Terri M. Teshiba, Zvart Abaryan, Noor B. Al-Sharif, Marissa Ericson, Maria Jalbrzikowski, Jurjen J. Luykx, Linda Navarro, Todd A. Tishler, Lori Altshuler, George Bartzokis, Javier Escobar, David C. Glahn, Jorge Ospina-Duque, Neil Risch, Andrés Ruiz-Linares, Paul M. Thompson, Rita M. Cantor, Carlos Lopez-Jaramillo, Gabriel Macaya, Julio Molina, Victor I. Reus, Chiara Sabatti, Nelson B. Freimer, Carrie E. Bearden

Publikováno v: JAMA psychiatry, vol 71, iss 4

ImportanceGenetic factors contribute to risk for bipolar disorder (BP), but its pathogenesis remains poorly understood. A focus on measuring multisystem quantitative traits that may be components of BP psychopathology may enable genetic dissection of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ee7032f2e75f3642a57eef380c2e323
https://pubmed.ncbi.nlm.nih.gov/27192493