Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Xinheng He"'
Autor:
Yang Li, Qingning Yuan, Xinheng He, Yumu Zhang, Chongzhao You, Canrong Wu, Jingru Li, H. Eric Xu, Li-Hua Zhao
Publikováno v:
Cell Discovery, Vol 10, Iss 1, Pp 1-12 (2024)
Abstract Prolactin-releasing peptide (PrRP) is an RF-amide neuropeptide that binds and activates its cognate G protein-coupled receptor, prolactin-releasing peptide receptor (PrRPR), also known as GPR10. PrRP and PrRPR are highly conserved across mam
Externí odkaz:
https://doaj.org/article/ffea06cafb9843238d672de7aa5cd414
Autor:
Miao Zheng, Bo Feng, Yumin Zhang, Xin Liu, Na Zhao, Hui Liu, Zichao Xu, Xinheng He, Zhiyan Qu, Shizhao Chen, Zhidong Jiang, Xi Cheng, Hong Liu, Yi Zang, Linxiang Zhao, Jie Zheng, Leike Zhang, Jia Li, Yu Zhou
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 7, Pp 3286-3290 (2024)
Externí odkaz:
https://doaj.org/article/0507dae3bcfe403cb289ec049acee92e
Autor:
Xinheng He, Lifen Zhao, Yinping Tian, Rui Li, Qinyu Chu, Zhiyong Gu, Mingyue Zheng, Yusong Wang, Shaoning Li, Hualiang Jiang, Yi Jiang, Liuqing Wen, Dingyan Wang, Xi Cheng
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract As the most abundant organic substances in nature, carbohydrates are essential for life. Understanding how carbohydrates regulate proteins in the physiological and pathological processes presents opportunities to address crucial biological p
Externí odkaz:
https://doaj.org/article/f09ba2c370cc4208899023e31dad4830
Autor:
Sanshan Jin, Shimeng Guo, Youwei Xu, Xin Li, Canrong Wu, Xinheng He, Benxun Pan, Wenwen Xin, Heng Zhang, Wen Hu, Yuling Yin, Tianwei Zhang, Kai Wu, Qingning Yuan, H. Eric Xu, Xin Xie, Yi Jiang
Publikováno v:
Cell Discovery, Vol 10, Iss 1, Pp 1-13 (2024)
Abstract The neuropeptide 26RFa, a member of the RF-amide peptide family, activates the pyroglutamylated RF-amide peptide receptor (QRFPR), a class A GPCR. The 26RFa/QRFPR system plays critical roles in energy homeostasis, making QRFPR an attractive
Externí odkaz:
https://doaj.org/article/1dd02c6ef3f34c349ea569c47548e552
Autor:
Qian He, Qingning Yuan, Hong Shan, Canrong Wu, Yimin Gu, Kai Wu, Wen Hu, Yumu Zhang, Xinheng He, H. Eric Xu, Li-Hua Zhao
Publikováno v:
Cell Discovery, Vol 10, Iss 1, Pp 1-13 (2024)
Abstract Melanin-concentrating hormone (MCH) is a cyclic neuropeptide that regulates food intake, energy balance, and other physiological functions by stimulating MCHR1 and MCHR2 receptors, both of which are class A G protein-coupled receptors. MCHR1
Externí odkaz:
https://doaj.org/article/26f5adc57d7e4d8891df0876082f58fe
Publikováno v:
Cell Reports, Vol 43, Iss 8, Pp 114511- (2024)
Summary: Bombesin receptor subtype-3 (BRS3) is an important orphan G protein-coupled receptor that regulates energy homeostasis and insulin secretion. As a member of the bombesin receptor (BnR) family, the lack of known endogenous ligands and high-re
Externí odkaz:
https://doaj.org/article/854de4b8d8a54817b8b51437325d9661
Autor:
Shiyi Shen, Dongxue Wang, Heng Liu, Xinheng He, Yinglong Cao, Juanhua Chen, Shujie Li, Xi Cheng, H. Eric Xu, Jia Duan
Publikováno v:
Cell Reports, Vol 43, Iss 7, Pp 114389- (2024)
Summary: Kisspeptin signaling through its G protein-coupled receptor, KISS1R, plays an indispensable role in regulating reproduction via the hypothalamic-pituitary-gonadal axis. Dysregulation of this pathway underlies severe disorders like infertilit
Externí odkaz:
https://doaj.org/article/9c255df8d34046729b6af43aebba673c
Autor:
Yusong Wang, Tong Wang, Shaoning Li, Xinheng He, Mingyu Li, Zun Wang, Nanning Zheng, Bin Shao, Tie-Yan Liu
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Geometric deep learning has been revolutionizing the molecular modeling field. Despite the state-of-the-art neural network models are approaching ab initio accuracy for molecular property prediction, their applications, such as drug discover
Externí odkaz:
https://doaj.org/article/71536d430cfd44f18d739029f207ec11
Publikováno v:
Scientific Data, Vol 10, Iss 1, Pp 1-12 (2023)
Abstract Molecular dynamics (MD) simulations have revolutionized the modeling of biomolecular conformations and provided unprecedented insight into molecular interactions. Due to the prohibitive computational overheads of ab initio simulation for lar
Externí odkaz:
https://doaj.org/article/25bd12afe3bd4e0c8d83896c23b8488c
Autor:
Heng Liu, Qing Zhang, Xinheng He, Mengting Jiang, Siwei Wang, Xiaoci Yan, Xi Cheng, Yang Liu, Fa-Jun Nan, H. Eric Xu, Xin Xie, Wanchao Yin
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract GPR84 is an orphan class A G protein-coupled receptor (GPCR) that is predominantly expressed in immune cells and plays important roles in inflammation, fibrosis, and metabolism. Here, we present cryo-electron microscopy (cryo-EM) structures
Externí odkaz:
https://doaj.org/article/93122ec4fc19412c942ed11b75e97520