Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Xinhe Xue"'
Autor:
Xin Yang, Zhiyi Wang, Junling Niu, Rui Zhai, Xinhe Xue, Guojun Wu, Yuanyuan Fang, Guangxun Meng, Huijuan Yuan, Liping Zhao, Chenhong Zhang
Publikováno v:
Microbiome, Vol 11, Iss 1, Pp 1-20 (2023)
Abstract Background Dysbiotic gut microbiome, genetically predisposed or chemically disrupted, has been linked with insulin-dependent diabetes (IDD) including autoimmune type 1 diabetes (T1D) in both humans and animal models. However, specific IDD-in
Externí odkaz:
https://doaj.org/article/0ffca464297e4d4793ddaefd32d05767
Autor:
Mateusz Legut, Zharko Daniloski, Xinhe Xue, Dayna McKenzie, Xinyi Guo, Hans-Hermann Wessels, Neville E. Sanjana
Publikováno v:
Cell Reports, Vol 30, Iss 9, Pp 2859-2868.e5 (2020)
Summary: A key limitation of the widely used CRISPR enzyme S. pyogenes Cas9 is the strict requirement of an NGG protospacer-adjacent motif (PAM) at the target site. This constraint can be limiting for genome editing applications that require precise
Externí odkaz:
https://doaj.org/article/65cbd1ad7de249df8e2e72fd5635a205
Publikováno v:
mSystems, Vol 4, Iss 6 (2019)
ABSTRACT Calorie restriction (CR) is accompanied by self-imposed daily restriction of food intake and an extended fasting period between meals. The impact of restricting feeding to the dark or light phase on the effects of CR remains elusive. Here, l
Externí odkaz:
https://doaj.org/article/a9155da135404655a02467a48a6b3f65
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 9 (2019)
Akkermansia muciniphila is potential probiotic in that its type strain ATCC BAA-835 has beneficial effects upon obesity and diabetes. However, whether A. muciniphila can improve inflammatory bowel diseases (IBD), which is a form of chronic intestinal
Externí odkaz:
https://doaj.org/article/7e6ff53fe3e24af696523cd0383e16ce
Autor:
Ruirui Wang, Hui Li, Xin Yang, Xinhe Xue, Liman Deng, Jian Shen, Menghui Zhang, Liping Zhao, Chenhong Zhang
Publikováno v:
Frontiers in Microbiology, Vol 9 (2018)
Dysbiotic gut microbiota contributes to genetically obese phenotype in human. However, the effect of genetic obesity-associated gut microbiota on host hepatic metabolic deteriorations remains largely unknown. Gut microbiota from a genetically obese h
Externí odkaz:
https://doaj.org/article/d0ed5ce3be8d406d88dddee30dfb5458
Autor:
Mateusz Legut, Zoran Gajic, Maria Guarino, Zharko Daniloski, Jahan A. Rahman, Xinhe Xue, Congyi Lu, Lu Lu, Eleni P. Mimitou, Stephanie Hao, Teresa Davoli, Catherine Diefenbach, Peter Smibert, Neville E. Sanjana
Publikováno v:
Nature
The engineering of patient T-cells for adoptive cell therapies has revolutionised the treatment of several cancer types(1). However, further improvements are needed to increase response and cure rates. CRISPR-based loss-of-function screens have been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69bc54d693b5eb42b5b21e001aa01b9d
https://doi.org/10.1038/s41586-022-04494-7
https://doi.org/10.1038/s41586-022-04494-7
Autor:
Mateusz Legut, Maria Guarino, Xinhe Xue, Congyi Lu, Radha Vyas, Catherine S. Diefenbach, Neville Sanjana
Publikováno v:
Blood. 140:10235-10236
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f707a65aeeb2437742a461bd7f453ec
https://doi.org/10.1182/blood-2022-163230
https://doi.org/10.1182/blood-2022-163230
This study aimed to investigate the effects and mechanisms of miRNA-140 in exosomes of hypoxic bone marrow mesenchymal stem cells on articular chondrocytes. Articular chondrocytes were stimulated with IL-1β (10 μg/ml) to give them an inflammatory s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e871b18533102285aa3a4e04da3f659d
https://doi.org/10.21203/rs.3.rs-1763964/v1
https://doi.org/10.21203/rs.3.rs-1763964/v1
Autor:
Xin Yang, Zhiyi Wang, Junling Niu, Rui Zhai, Xinhe Xue, Guojun Wu, Guangxun Meng, Huijuan Yuan, Liping Zhao, Chenhong Zhang
BackgroundDysbiotic gut microbiome, genetically predisposed or chemically disrupted, has been linked with insulin-dependent diabetes (IDD) including autoimmune type 1 diabetes (T1D) in both humans and animal models. However, specific IDD-inducing gut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::55ec806bb3e435baad68a2403c19d1ef
https://doi.org/10.1101/2022.06.05.494898
https://doi.org/10.1101/2022.06.05.494898
Autor:
Neville E. Sanjana, Xinyi Guo, Dayna McKenzie, Xinhe Xue, Mateusz Legut, Zharko Daniloski, Hans-Hermann Wessels
Publikováno v:
Cell reports
Cell Reports, Vol 30, Iss 9, Pp 2859-2868.e5 (2020)
Cell Reports, Vol 30, Iss 9, Pp 2859-2868.e5 (2020)
SUMMARY A key limitation of the widely used CRISPR enzyme S. pyogenes Cas9 is the strict requirement of an NGG protospacer-adjacent motif (PAM) at the target site. This constraint can be limiting for genome editing applications that require precise C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::960abe9c6ffe28d1c6859a07a14fc564