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pro vyhledávání: '"Xinhao Cynthia Fan"'
Autor:
Joan A. Steitz, Xinhao Cynthia Fan
Publikováno v:
Proceedings of the National Academy of Sciences. 95:15293-15298
Proteins are transported into and out of the cell nucleus via specific signals. The two best-studied nuclear transport processes are mediated either by classical nuclear localization signals or nuclear export signals. There also are shuttling sequenc
Publikováno v:
Genes & Development. 11:2557-2568
Targeted mRNA instability represents an important mode of post-transcriptional gene regulation in eukaryotic cells. Much attention has focused on AU-rich elements (AREs) that are present in the 3′-untranslated regions (3′ UTRs) of the mRNAs from
Autor:
Jin Gene Wang, Mark Collinge, Ruggero Pardi, Jeffrey R. Bender, Xinhao Cynthia Fan, Vinod S. Ramgolam, Oran Ayalon
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 176(4)
Lymphokine gene expression is a precisely regulated process in T cell-mediated immune responses. In this study we demonstrate that engagement of the β2 integrin LFA-1 in human peripheral T cells markedly extends the half-life of TNF-α, GM-CSF, and
Autor:
Joan A. Steitz, Xinhao Cynthia Fan
Publikováno v:
The EMBO journal. 17(12)
The messenger RNAs of many proto‐oncogenes, cytokines and lymphokines are targeted for rapid degradation through AU‐rich elements (AREs) located in their 3′ untranslated regions (UTRs). HuR, a ubiquitously expressed member of the Elav family of