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Akademický článek

Regulatory Dendritic Cells Induced by K313 Display Anti-Inflammatory Properties and Ameliorate Experimental Autoimmune Encephalitis in Mice

Autor: Yan Zhou, Xiao Leng, Xingyan Luo, Chunfen Mo, Qiang Zou, Yang Liu, Yantang Wang

Publikováno v: Frontiers in Pharmacology, Vol 10 (2020)

As a GSK-3β inhibitor reported by our group, K313 is a novel benzoxazole derivative and displays anti-inflammatory properties in RAW264.7 macrophages without cytotoxicity. The activity of GSK-3β affects the differentiation and maturation of bone ma

Externí odkaz: https://doaj.org/article/691d4aeccb7442368fa42d95afc0c793

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Akademický článek

Tolerogenic Dendritic Cells Generated with Tofacitinib Ameliorate Experimental Autoimmune Encephalomyelitis through Modulation of Th17/Treg Balance

Autor: Yan Zhou, Xiao Leng, Shasha Luo, Zhiwei Su, Xingyan Luo, Huijie Guo, Chunfen Mo, Qiang Zou, Yang Liu, Yantang Wang

Publikováno v: Journal of Immunology Research, Vol 2016 (2016)

It is well known that dendritic cells (DCs) play a pivotal role in triggering self-specific responses. Conversely, tolerogenic DCs (tolDCs), a specialized subset, induce tolerance and negatively regulate autoreactive responses. Tofacitinib, a Janus k

Externí odkaz: https://doaj.org/article/041c1e2ebbe24910a2a4e9c8cb5326ae

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Akademický článek

3D-QSAR Studies of Dihydropyrazole and Dihydropyrrole Derivatives as Inhibitors of Human Mitotic Kinesin Eg5 Based on Molecular Docking

Autor: Wenjuan Yang, Zhihua Lin, Yuanqiang Wang, Jin Liu, Mao Shu, Xingyan Luo

Publikováno v: Molecules, Vol 17, Iss 2, Pp 2015-2029 (2012)

Human mitotic kinesin Eg5 plays an essential role in mitoses and is an interesting drug target against cancer. To find the correlation between Eg5 and its inhibitors, structure-based 3D-quantitative structure–activity relationship (QSAR) studies we

Externí odkaz: https://doaj.org/article/26da66bc686848f481d0aa579ac4ecae

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Sis-25, a meroditerpenoid derivative with a cyclobutane scaffold, inhibits activated T cell proliferation by targeting GSK3β in vitro and in vivo

Autor: Yang Liu, Xingren Li, Xiuyin Wu, Xingyan Luo, Bingchao Yan, Chunfen Mo, Huijie Guo, Shuxia Yang, Yantang Wang, Yi Lai, Pematenzin Puno, Limei Li

Publikováno v: European journal of pharmacology. 929

A series of novel scopariusicide derivatives were designed and synthesized starting from the main diterpenoid from the aerial parts of Isodon scoparius. Sis-25 was the most effective compound among them. The potential mechanism(s) of its immunosuppre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca820498ff1c3409293537aeed3bc1f9
https://pubmed.ncbi.nlm.nih.gov/35841942

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Akademický článek

3D-QSAR Studies of Dihydropyrazole and Dihydropyrrole Derivatives as Inhibitors of Human Mitotic Kinesin Eg5 Based on Molecular Docking.

Autor: Xingyan Luo¹, Mao Shu¹ sm7507@126.com, Yuanqiang Wang¹, Jin Liu¹, Wenjuan Yang¹, Zhihua Lin¹ zhlin@cqut.edu.cn

Publikováno v: Molecules. Feb2012, Vol. 17 Issue 2, p2015-2029. 15p. 3 Diagrams, 3 Charts, 1 Graph.

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3D-QSAR studies of dihydropyrazole and dihydropyrrole derivatives as inhibitors of human mitotic kinesin Eg5 based on molecular docking

Autor: Zhihua Lin, Xingyan Luo, Jin Liu, Wenjuan Yang, Yuanqiang Wang, Mao Shu

Publikováno v: Molecules
Molecules; Volume 17; Issue 2; Pages: 2015-2029
Molecules, Vol 17, Iss 2, Pp 2015-2029 (2012)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b613907a6b9f7d248f27f8381e91943
https://pubmed.ncbi.nlm.nih.gov/22343406

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