Mesenchymal Stromal Cells Isolated from Irradiated Human Skin Have Diminished Capacity for Proliferation, Differentiation, Colony Formation, and Paracrine Stimulation

Autor: Maxwell B. Johnson, Solmaz Niknam‐Bienia, Vinaya Soundararajan, Brandon Pang, Eunson Jung, Daniel J. Gardner, Xingtian Xu, Sun Y. Park, Charles Wang, Xin Chen, Regina Y. Baker, Mei Chen, Young‐Kwon Hong, Wei Li, Alex K. Wong

Publikováno v: Stem Cells Translational Medicine, Vol 8, Iss 9, Pp 925-934 (2019)

Abstract Ionizing radiation, commonly used in the treatment of solid tumors, has unintended but deleterious effects on overlying skin and is associated with chronic nonhealing wounds. Skin‐derived mesenchymal stromal cells (SMSCs) are a pluripotent

Externí odkaz: https://doaj.org/article/60ae7a786f924412a403b856cb5af673

Mechanical Characterization and Material Modeling of Diabetic Aortas in a Rabbit Model

Autor: X. Li, Guixue Wang, Xingtian Xu, Jianhua Tong, F. Yang

Publikováno v: Annals of Biomedical Engineering. 46:429-442

Diabetes has been recognized as a major risk factor to cause macrovascular diseases and plays a key role in aortic wall remodeling. However, the effects of diabetes on elastic properties of aortas remain largely unknown and quantitative mechanical da

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41db22de33c6e3882801605976fc4ff5
https://doi.org/10.1007/s10439-017-1955-9

Local Administration of Interleukin-1 Receptor Antagonist Improves Diabetic Wound Healing

Autor: David P. Perrault, Alexander Wong, Songtao Shi, Athanasios Bramos, Xingtian Xu

Publikováno v: Annals of plastic surgery. 80(5S Suppl 5)

Impaired healing of the skin is a notable cause of patient morbidity and mortality. In diabetic individuals, dysregulated inflammation contributes to delayed wound healing. Specific immunomodulatory agents may have a role in the treatment of diabetic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab9492842bbbb3eef8b1aaa217c4b265
https://pubmed.ncbi.nlm.nih.gov/29553981

Telomerase governs immunomodulatory properties of mesenchymal stem cells by regulating FAS ligand expression

Autor: Songtao Shi, Chider Chen, Yimin Zhao, Kentaro Akiyama, Yong-Ouk You, Xingtian Xu, Takayoshi Yamaza, Bei Li

Publikováno v: EMBO Molecular Medicine, Vol 6, Iss 3, Pp 322-334 (2014)
EMBO Molecular Medicine

Bone marrow mesenchymal stem cells (BMMSCs) are capable of differentiating into multiple cell types and regulating immune cell response. However, the mechanisms that govern the immunomodulatory properties of BMMSCs are still not fully elucidated. Her

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5e407cf2ee64095c2ec295545ce3b38
https://doaj.org/article/91a7db620a7641c4a733bd564e305ba5

Muscle tissue engineering using gingival mesenchymal stem cells encapsulated in alginate hydrogels containing multiple growth factors

Autor: Songtao Shi, Ali Khademhosseini, Alireza Moshaverinia, Xingtian Xu, Sahar Ansari, Chider Chen, Nasim Annabi, Benjamin M. Wu, Homayoun H. Zadeh

Publikováno v: Annals of biomedical engineering, vol 44, iss 6
Ansari, S; Chen, C; Xu, X; Annabi, N; Zadeh, HH; Wu, BM; et al.(2016). Muscle Tissue Engineering Using Gingival Mesenchymal Stem Cells Encapsulated in Alginate Hydrogels Containing Multiple Growth Factors. ANNALS OF BIOMEDICAL ENGINEERING, 44(6), 1908-1920. doi: 10.1007/s10439-016-1594-6. UCLA: Retrieved from: http://www.escholarship.org/uc/item/42461162

Repair and regeneration of muscle tissue following traumatic injuries or muscle diseases often presents a challenging clinical situation. If a significant amount of tissue is lost the native regenerative potential of skeletal muscle will not be able

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::081da715b94fee61953cff6ee5ab2fca
https://europepmc.org/articles/PMC4880526/