Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Xingping Su"'
Autor:
Yuting Xie, Lin Yue, Yaojie Shi, Xingping Su, Cailing Gan, Hongyao Liu, Taixiong Xue, Tinghong Ye
Publikováno v:
Journal of Medicinal Chemistry. 66:4342-4360
Autor:
Taixiong Xue, Lin Yue, Guonian Zhu, Zui Tan, Hongyao Liu, Cailing Gan, Chen Fan, Xingping Su, Yuting Xie, Tinghong Ye
Publikováno v:
Liver international : official journal of the International Association for the Study of the Liver.
Liver fibrosis is an excessive wound-healing response governed by activated hepatic stellate cells (HSCs). To date, there is no drug available for liver fibrosis. Although ferulic acid (FA) has multiple pharmacological functions, its anti-hepatic fib
Autor:
Yijie Wang, Hongyao Liu, Wenzhen Li, Yuting Xie, Cailing Gan, Taixiong Xue, Xingping Su, Lin Yue, Qin Wang, Chen Fan, Yiwen Zhang, Tinghong Ye
Publikováno v:
European journal of medicinal chemistry. 246
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive lung disease of unknown aetiology with limited treatment options. Currently, only two drugs, nintedanib and pirfenidone, are approved for the clinical treatment of IPF, but their efficacie
Autor:
Xingping Su, Zui Tan, Guan Wang, Zhihao Liu, Cailing Gan, Lin Yue, Hongyao Liu, Yuting Xie, Yuqin Yao, Tinghong Ye
Publikováno v:
European journal of medicinal chemistry. 245(Pt 2)
Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease characterized with high mortality, unknown etiology, and lack of effective treatment. Many evidences validate that inhibiting the activation of STAT3 is an attractive therapeutic strategy fo
Autor:
Yongxia Zhu, Rong Hu, Tinghong Ye, Xiuli Wu, Wei Wei, Hualong He, Luoting Yu, Xi Hu, Qi-Wei Wang, Zhihao Liu, Ning-Yu Wang, Xingping Su, Shu-Yan Zhou, Qiangsheng Zhang
Publikováno v:
Journal of Medicinal Chemistry. 64:2829-2848
EZH2 mediates both PRC2-dependent gene silencing via catalyzing H3K27me3 and PRC2-independent transcriptional activation in various cancers. Given its oncogenic role in cancers, EZH2 has constituted a compelling target for anticancer therapy. However
Autor:
Yi Luo, Xingping Su, Xiuli Wu, Liu Zhihao, Tinghong Ye, Hanyun Que, Wei Wei, Lin Yue, Yiwen Zhang
Publikováno v:
RSC Advances. 11:20651-20661
Abnormal activation of FGFR signaling pathway plays an essential role in various types of tumors. Therefore, targeting FGFRs represents an attractive strategy for cancer therapy. Herein, we report a series of 1H-pyrrolo[2,3-b]pyridine derivatives wit
Autor:
Xiuli Wu, Zhihao Liu, Cailin Gan, Wei Wei, Qianyu Zhang, Hongyao Liu, Hanyun Que, Xingping Su, Lin Yue, Hualong He, Liang Ouyang, Tinghong Ye
Publikováno v:
Bioorganic chemistry. 127
Gastric cancer is the second most lethal cancer across the world. With the progress in therapeutic approaches, the 5-year survival rate of early gastric cancer can reach 95%. However, the prognosis and survival time of advanced gastric cancer is stil
Autor:
Lin, Yue, Taixiong, Xue, Xingping, Su, Zhihao, Liu, Hongyao, Liu, Zui, Tan, Cailing, Gan, Yuting, Xie, Tinghong, Ye
Publikováno v:
European Journal of Medicinal Chemistry. 242:114685
Liver fibrosis is characterized by the excessive deposition of extracellular matrix components and results from chronic liver injury. At present, there is no approved drug for the treatment of liver fibrosis by the Food and Drug Administration. Here,
Autor:
Liqun Wang, Hongyao Liu, Yuqin Yao, Xiuli Wu, Tinghong Ye, Wei Wei, Qianyu Zhang, Zui Tan, Xingping Su, Luoting Yu, Zhihao Liu, Liang Ouyang, Lin Yue, Guan Wang, Cailing Gan
Publikováno v:
Cell Proliferation
Objectives Idiopathic pulmonary fibrosis (IPF) is marked by the excessive accumulation of extracellular matrix, which participates in a variety of chronic diseases or injuries and seriously threatens human health. Due to the side effects of clinical
Publikováno v:
European journal of medicinal chemistry. 224
Idiopathic pulmonary fibrosis (IPF) is a lethal disease with limited therapeutic options and a particularly poor prognosis. Matrix metalloproteinases (MMPs), promising targets for the treatment of IPF, have been identified as playing a pivotal role i