Zobrazeno 1 - 10
of 237
pro vyhledávání: '"Xingming Deng"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Resistance to radiotherapy is a major barrier during cancer treatment. Here using genome-scale CRISPR/Cas9 screening, we identify CD274 gene, which encodes PD-L1, to confer lung cancer cell resistance to ionizing radiation (IR). Depletion of
Externí odkaz:
https://doaj.org/article/0b289724e1b44bbcb80ea46562b400e9
Autor:
Yikun Li, Ping Yue, Xingming Deng, Takeshi Ueda, Rikiro Fukunaga, Fadlo R Khuri, Shi-Yong Sun
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 56, Iss , Pp 101031- (2024)
Externí odkaz:
https://doaj.org/article/6ddd5d45ca5049cebddc5ad535e6a951
Autor:
Priya Kapoor-Vazirani, Sandip K. Rath, Xu Liu, Zhen Shu, Nicole E. Bowen, Yitong Chen, Ramona Haji-Seyed-Javadi, Waaqo Daddacha, Elizabeth V. Minten, Diana Danelia, Daniela Farchi, Duc M. Duong, Nicholas T. Seyfried, Xingming Deng, Eric A. Ortlund, Baek Kim, David S. Yu
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
SAMHD1 has a dNTPase-independent resection function in genome maintenance. Here the authors show that SAMHD1 is deacetylated at conserved K354 by SIRT1 to facilitate direct binding with ssDNA to promote DNA end resection and homologous recombination.
Externí odkaz:
https://doaj.org/article/28cc02127faa4de9bf5e662150744115
Publikováno v:
Sensors, Vol 23, Iss 6, p 2904 (2023)
Due to the openness of communication network and the complexity of system structures, multi-agent systems are vulnerable to malicious network attacks, which can cause intense instability to these systems. This article provides a survey of state-of-th
Externí odkaz:
https://doaj.org/article/32c1f94a4e6449758af3ad60bf17f61d
Publikováno v:
Frontiers in Oncology, Vol 11 (2022)
BackgroundThe difficulties of early diagnosis of colorectal cancer (CRC) result in a high mortality rate. The ability to predict the response of a patient to surgical resection or chemotherapy may be of great value for clinicians when planning CRC tr
Externí odkaz:
https://doaj.org/article/c4b6c84cebdf4a04849db76716c15819
Autor:
Guo Chen, Yin Luo, Kurt Warncke, Youwei Sun, David S. Yu, Haian Fu, Madhusmita Behera, Suresh S. Ramalingam, Paul W. Doetsch, Duc M. Duong, Michael Lammers, Walter J. Curran, Xingming Deng
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Ribonucleotide reductase (RNR) catalyzes the de novo synthesis of deoxyribonucleoside diphosphates to provide dNTP precursors for DNA synthesis. Here the authors show that the availability of dNTPs, DNA replication, and cellular proliferation, are mo
Externí odkaz:
https://doaj.org/article/d07d654e84db43299a467240e28b6a80
Autor:
Ke Xu, Dongkyoo Park, Andrew T. Magis, Jun Zhang, Wei Zhou, Gabriel L. Sica, Suresh S. Ramalingam, Walter J. Curran, Xingming Deng
Publikováno v:
Molecular Cancer, Vol 18, Iss 1, Pp 1-16 (2019)
Abstract Background Lung cancer patients with KRAS mutation(s) have a poor prognosis due in part to the development of resistance to currently available therapeutic interventions. Development of a new class of anticancer agents that directly targets
Externí odkaz:
https://doaj.org/article/3f768d5575f04b929f12a8fef492e1de
Autor:
Waaqo Daddacha, Allyson E. Koyen, Amanda J. Bastien, PamelaSara E. Head, Vishal R. Dhere, Geraldine N. Nabeta, Erin C. Connolly, Erica Werner, Matthew Z. Madden, Michele B. Daly, Elizabeth V. Minten, Donna R. Whelan, Ashley J. Schlafstein, Hui Zhang, Roopesh Anand, Christine Doronio, Allison E. Withers, Caitlin Shepard, Ranjini K. Sundaram, Xingming Deng, William S. Dynan, Ya Wang, Ranjit S. Bindra, Petr Cejka, Eli Rothenberg, Paul W. Doetsch, Baek Kim, David S. Yu
Publikováno v:
Cell Reports, Vol 20, Iss 8, Pp 1921-1935 (2017)
DNA double-strand break (DSB) repair by homologous recombination (HR) is initiated by CtIP/MRN-mediated DNA end resection to maintain genome integrity. SAMHD1 is a dNTP triphosphohydrolase, which restricts HIV-1 infection, and mutations are associate
Externí odkaz:
https://doaj.org/article/0fff215953bf4b47a57af665f31bccaf
Autor:
Guo Chen, Xingming Deng
Publikováno v:
Bio-Protocol, Vol 8, Iss 17 (2018)
Cell synchronization is widely used in studying mechanisms involves in regulation of cell cycle progression. Through synchronization, cells at distinct cell cycle stage could be obtained. Thymidine is a DNA synthesis inhibitor that can arrest cell at
Externí odkaz:
https://doaj.org/article/74804412f65944f991e057cefcce6ef0
Autor:
Hui Zhang, PamelaSara E. Head, Waaqo Daddacha, Seong-Hoon Park, Xingzhe Li, Yunfeng Pan, Matthew Z. Madden, Duc M. Duong, Maohua Xie, Bing Yu, Matthew D. Warren, Elaine A. Liu, Vishal R. Dhere, Chunyang Li, Ivan Pradilla, Mylin A. Torres, Ya Wang, William S. Dynan, Paul W. Doetsch, Xingming Deng, Nicholas T. Seyfried, David Gius, David S. Yu
Publikováno v:
Cell Reports, Vol 14, Iss 6, Pp 1435-1447 (2016)
The ataxia telangiectasia-mutated and Rad3-related (ATR) kinase checkpoint pathway maintains genome integrity; however, the role of the sirtuin 2 (SIRT2) acetylome in regulating this pathway is not clear. We found that deacetylation of ATR-interactin
Externí odkaz:
https://doaj.org/article/f2ddce6c8fc04efcab79c55c54406ab7