Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Xingjiang YU"'
Autor:
Qiuhong Zhu, Panpan Liang, Hao Meng, Fangzhen Li, Wei Miao, Cuiying Chu, Wei Wang, Dongxue Li, Cong Chen, Yu Shi, Xingjiang Yu, Yifang Ping, Chaoshi Niu, Hai-bo Wu, Aili Zhang, Xiu-wu Bian, Wenchao Zhou
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract The peptidyl-prolyl cis-trans isomerase Pin1 is a pivotal therapeutic target in cancers, but the regulation of Pin1 protein stability is largely unknown. High Pin1 expression is associated with SUMO1-modified protein hypersumoylation in glio
Externí odkaz:
https://doaj.org/article/68d6219593424984988e9b55888ae088
Transgelin Promotes Glioblastoma Stem Cell Hypoxic Responses and Maintenance Through p53 Acetylation
Autor:
Huan Li, Chao Song, Yang Zhang, Guohao Liu, Hailong Mi, Yachao Li, Zhiye Chen, Xiaoyu Ma, Po Zhang, Lidong Cheng, Peng Peng, Hongtao Zhu, Zirong Chen, Minhai Dong, Sui Chen, Hao Meng, QunGen Xiao, Honglian Li, Qiulian Wu, Baofeng Wang, Suojun Zhang, Kai Shu, Feng Wan, Dongsheng Guo, Wenchao Zhou, Lin Zhou, Feng Mao, Jeremy N. Rich, Xingjiang Yu
Publikováno v:
Advanced Science, Vol 11, Iss 7, Pp n/a-n/a (2024)
Abstract Glioblastoma (GBM) is a lethal cancer characterized by hypervascularity and necrosis associated with hypoxia. Here, it is found that hypoxia preferentially induces the actin‐binding protein, Transgelin (TAGLN), in GBM stem cells (GSCs). Me
Externí odkaz:
https://doaj.org/article/95216e81a5c74d7e8e6af9ccdf165215
Autor:
Jing Hao, Xiangzi Han, Haidong Huang, Xingjiang Yu, Jiankang Fang, Jianjun Zhao, Richard A. Prayson, Shideng Bao, Jennifer S. Yu
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract The Wnt pathway is frequently dysregulated in many cancers, underscoring it as a therapeutic target. Wnt inhibitors have uniformly failed in clinical trials. Here, we report a mechanism of WNT pathway activation through the Semaphorin 3 C ne
Externí odkaz:
https://doaj.org/article/755b7c691e6f4c8daf2bd64dcdd8c5bd
Publikováno v:
Journal of Ovarian Research, Vol 16, Iss 1, Pp 1-12 (2023)
Abstract Background Prednisone is one of the most used synthetic glucocorticoids during pregnancy. Epidemiological investigations suggested that prenatal prednisone therapy could affect fetal development, but systematic studies on its effects on ovar
Externí odkaz:
https://doaj.org/article/230db391ace84228b0e97ee4536a6265
Autor:
Ye Zheng, Xiaoyu Ma, Shouchang Feng, Hongtao Zhu, Xin Chen, Xingjiang Yu, Kai Shu, Suojun Zhang
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Gliomas account for the majority of brain malignant tumors. As the most malignant subtype of glioma, glioblastoma (GBM) is barely effectively treated by traditional therapies (surgery combined with radiochemotherapy), resulting in poor prognosis. Mea
Externí odkaz:
https://doaj.org/article/31d9924333c144459c7e30544ce46003
Autor:
Jing Hao, Xiangzi Han, Haidong Huang, Xingjiang Yu, Jiankang Fang, Jianjun Zhao, Richard A. Prayson, Shideng Bao, Jennifer S. Yu
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/a2dd8912850549ceb2df62b7241c2302
Autor:
Ting Li, Wei Li, Ying Li, Sui Chen, Qian Gao, Xiaopeng Li, Po Zhang, Jinyang Hu, Feng Dong, You He, Xianyou Xia, Fangling Cheng, Xiaoshuang Hou, Guohao Liu, Minhai Dong, Qungen Xiao, Xingjiang Yu, Guifa Xi, Dongsheng Guo, Xudong Wu, Baofeng Wang
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 9 (2022)
Background Glioblastoma (GBM) is the most common malignant brain tumor with poor clinical outcomes. Immunotherapy has recently been an attractive and promising treatment of extracranial malignancies, however, most of clinical trials for GBM immunothe
Externí odkaz:
https://doaj.org/article/d100b5cfc0af4ee5972992117bc14884
Autor:
Cuifang Ye, Huan Li, Yachao Li, Yang Zhang, Guohao Liu, Hailong Mi, Honglian Li, Qungen Xiao, Li Niu, Xingjiang Yu
Publikováno v:
iScience, Vol 25, Iss 9, Pp 104872- (2022)
Summary: Glioma stem cells (GSCs) in the hypoxic niches contribute to tumor initiation, progression, and recurrence in glioblastoma (GBM). Hypoxia induces release of high-mobility group box 1 (HMGB1) from tumor cells, promoting the development of tum
Externí odkaz:
https://doaj.org/article/cd8cbc0aa2f84355b2eceee8f11724a6
Autor:
Hongtao Zhu, Dan Liu, Lidong Cheng, Jingdian Liu, Guanghui Wang, Huan Li, Yang Zhang, Hailong Mi, Suojun Zhang, Kai Shu, Xingjiang Yu
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Malignant glioma is the most common solid tumor of the adult brain, with high lethality and poor prognosis. Hence, identifying novel and reliable biomarkers can be advantageous for diagnosing and treating glioma. Several galectins encoded by LGALS ge
Externí odkaz:
https://doaj.org/article/98c1156444324a1882fbf91940f9a614
Autor:
Po Zhang, Guohao Liu, Jinyang Hu, Sui Chen, Baofeng Wang, Peng Peng, Xingjiang Yu, Dongsheng Guo
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
PurposeThe development and progression of glioma are associated with the tumor immune microenvironment. Diffuse low-grade gliomas (LGGs) with higher immunosuppressive microenvironment tend to have a poorer prognosis. The study aimed to find a biologi
Externí odkaz:
https://doaj.org/article/225095d986214cf5b5f058e084d137e0