Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Xingji Zheng"'
Autor:
Sandra Peña-Díaz, Joseph D. Chao, Celine Rens, Hasti Haghdadi, Xingji Zheng, Keegan Flanagan, Mary Ko, Tirosh Shapira, Adrian Richter, Danay Maestre-Batlle, Julio Ortiz Canseco, Maximiliano Gabriel Gutierrez, Khanh Dao Duc, Steven Pelech, Yossef Av-Gay
Publikováno v:
iScience, Vol 27, Iss 8, Pp 110555- (2024)
Summary: Compounds targeting host control of infectious diseases provide an attractive alternative to antimicrobials. A phenotypic screen of a kinase library identified compounds targeting glycogen synthase kinase 3 as potent inhibitors of Mycobacter
Externí odkaz:
https://doaj.org/article/733a7b48c7c74ef1be5a2e2bc8a78728
Autor:
Clement K. M. Tsui, Flavia Sorrentino, Gagandeep Narula, Alfonso Mendoza-Losana, Ruben Gonzalez del Rio, Esther Pérez Herrán, Abraham Lopez, Adama Bojang, Xingji Zheng, Modesto Jesus Remuiñán-Blanco, Yossef Av-Gay
Publikováno v:
Molecules, Vol 27, Iss 14, p 4446 (2022)
Mycobacterium tuberculosis (Mtb), the etiological agent of tuberculosis, is one of the most devastating infectious agents in the world. Chemical-genetic characterization through in vitro evolution combined with whole genome sequencing analysis was us
Externí odkaz:
https://doaj.org/article/f85721612f414ebf85bdd94ae33aa7c0
Autor:
Karen K Y Lam, Xingji Zheng, Roberto Forestieri, Aruna D Balgi, Matt Nodwell, Sarah Vollett, Hilary J Anderson, Raymond J Andersen, Yossef Av-Gay, Michel Roberge
Publikováno v:
PLoS Pathogens, Vol 8, Iss 5, p e1002691 (2012)
Tuberculosis, caused by Mycobacterium tuberculosis infection, is a major cause of morbidity and mortality in the world today. M. tuberculosis hijacks the phagosome-lysosome trafficking pathway to escape clearance from infected macrophages. There is i
Externí odkaz:
https://doaj.org/article/b5b29aa927074b68b0fa10d67f939761
Autor:
Clement K.M. Tsui, Flavia Sorrentino, Narula Gagandeep, Alfonso Mendoza Losanna, Ruben Gonzalez Rio, Esther Pérez Herrán, Abraham Lopez, Adama Bojang, Xingji Zheng, Modesto Jesus Remuinan-Blanco, Yossef Av-Gay
Mycobacterium tuberculosis (Mtb), the etiological agent of tuberculosis, is one of the most devastating infectious agents in the world. It causes chronic lung diseases to one third of the world’s population. Chemo-genetic characterization through i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f18598dbd39fc94439ed0577fdf109c
https://doi.org/10.21203/rs.3.rs-946186/v1
https://doi.org/10.21203/rs.3.rs-946186/v1
Autor:
Yossef Av-Gay, Xingji Zheng
Publikováno v:
Current Treatment Options in Infectious Diseases. 8:299-310
Tuberculosis (TB) is a devastating infectious disease that continues to plague the world, despite improved hygiene, massive vaccination efforts and an arsenal of chemotherapeutic agents. Mycobacterium tuberculosis (Mtb), the causative agent of TB, is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::42b05d8c1fe4039edcb206f874878a88
https://doi.org/10.1007/s40506-016-0098-0
https://doi.org/10.1007/s40506-016-0098-0
Autor:
Xingji, Zheng, Yossef, Av-Gay
Publikováno v:
Journal of visualized experiments : JoVE. (122)
Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), is a leading cause of morbidity and mortality worldwide. With the increased spread of multi drug-resistant TB (MDR-TB), there is a real urgency to develop new therapeutic strategie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b7974dc2dd7d7156228f6345c71f568d
https://pubmed.ncbi.nlm.nih.gov/28448028
https://pubmed.ncbi.nlm.nih.gov/28448028
Autor:
Yossef Av-Gay, Xingji Zheng
Publikováno v:
Journal of Visualized Experiments.
Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), is a leading cause of morbidity and mortality worldwide. With the increased spread of multi drug-resistant TB (MDR-TB), there is a real urgency to develop new therapeutic strategie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1eaa328f690c2c5b929b45f3ef82cbd7
https://doi.org/10.3791/55273-v
https://doi.org/10.3791/55273-v
Autor:
Lam, Karen K. Y.1, Xingji Zheng2, Forestieri, Roberto3, Balgi, Aruna D.1, Nodwell, Matt3, Vollett, Sarah1, Anderson, Hilary J.1, Andersen, Raymond J.3, Av-Gay, Yossef2, Roberge, Michel1 michelr@mail.ubc.ca
Publikováno v:
PLoS Pathogens. May2012, Vol. 8 Issue 5, Special section p1-15. 15p. 4 Diagrams, 1 Chart, 4 Graphs.
Autor:
Joseph D. Chao, Xingji Zheng, Guinevere Q. Lee, Ana Chavez-Steenbock, Xuetao Wang, K. G. Papavinasasundaram, Yossef Av-Gay
Publikováno v:
Journal of Biological Chemistry. 285:29239-29246
Signal transduction in Mycobacterium tuberculosis is mediated primarily by the Ser/Thr protein kinases and the two-component systems. The Ser/Thr kinase PknH has been shown to regulate growth of M. tuberculosis in a mouse model and in response to NO
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e8c8951cc5f498b9789804832c26cb9
https://doi.org/10.1074/jbc.m110.132894
https://doi.org/10.1074/jbc.m110.132894
Publikováno v:
Biochemical and Biophysical Research Communications. 355:162-168
PknH Ser/Thr protein kinase of Mycobacterium tuberculosis controls the expression of a variety of cell wall related enzymes and regulates the in vivo growth in mice. Therefore, we predicted that the PknH kinase could phosphorylate several substrates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63e7e34f8282beb6eb49db64a4fcfd5b
https://doi.org/10.1016/j.bbrc.2007.01.122
https://doi.org/10.1016/j.bbrc.2007.01.122