Zobrazeno 1 - 10
of 431
pro vyhledávání: '"Xinghua, Shi"'
Autor:
Chang Su, Yu Hou, Jielin Xu, Zhenxing Xu, Manqi Zhou, Alison Ke, Haoyang Li, Jie Xu, Matthew Brendel, Jacqueline R. M. A. Maasch, Zilong Bai, Haotan Zhang, Yingying Zhu, Molly C. Cincotta, Xinghua Shi, Claire Henchcliffe, James B. Leverenz, Jeffrey Cummings, Michael S. Okun, Jiang Bian, Feixiong Cheng, Fei Wang
Publikováno v:
npj Digital Medicine, Vol 7, Iss 1, Pp 1-22 (2024)
Abstract Parkinson’s disease (PD) is a serious neurodegenerative disorder marked by significant clinical and progression heterogeneity. This study aimed at addressing heterogeneity of PD through integrative analysis of various data modalities. We a
Externí odkaz:
https://doaj.org/article/c98b774780634551a2636756a95523ae
Publikováno v:
Communications Physics, Vol 7, Iss 1, Pp 1-9 (2024)
Abstract Developing physical methods to modulate biomolecular clusters and condensates on cell membranes is of great importance for understanding physiological and pathological processes as well as for stimulating novel therapeutic strategies. Here,
Externí odkaz:
https://doaj.org/article/133dfbc2492a4254918c8d6113c4eb16
Autor:
Vidhyanand Mahase, Adebiyi Sobitan, Qiaobin Yao, Xinghua Shi, Hong Qin, Dawit Kidane, Qiyi Tang, Shaolei Teng
Publikováno v:
Viruses, Vol 16, Iss 7, p 1150 (2024)
The global effort to combat the COVID-19 pandemic faces ongoing uncertainty with the emergence of Variants of Concern featuring numerous mutations on the Spike (S) protein. In particular, the Omicron Variant is distinguished by 32 mutations, includin
Externí odkaz:
https://doaj.org/article/201fd6b406764c71a040e0e4d24bd729
Autor:
Shichao Xu, Haifeng Wu, Siyuan Liu, Peidong Du, Hui Wang, Haijun Yang, Wenjie Xu, Shuangming Chen, Li Song, Jikun Li, Xinghua Shi, Zhen-Gang Wang
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Enzymes fold into unique three-dimensional structures to distribute their reactive amino acid residues, but environmental changes can disrupt their essential folding and lead to irreversible activity loss. The de novo synthesis of enzyme-lik
Externí odkaz:
https://doaj.org/article/4889c0b007104cd3b737136752b6c472
Publikováno v:
Physical Review Research, Vol 6, Iss 2, p 023014 (2024)
Non-Gaussian diffusion of nanoparticles in complex media disrupts Einstein's picture of Brownian motion, and non-Gaussianity is thought to be closely related to diffusing diffusivity generated by spatiotemporal heterogeneities. However, the correlati
Externí odkaz:
https://doaj.org/article/6aa9aed55f044b79bea6149801f970cc
Graphdiyne oxide nanosheets display selective anti-leukemia efficacy against DNMT3A-mutant AML cells
Autor:
Qiwei Wang, Ying Liu, Hui Wang, Penglei Jiang, Wenchang Qian, Min You, Yingli Han, Xin Zeng, Jinxin Li, Huan Lu, Lingli Jiang, Meng Zhu, Shilin Li, Kang Huang, Mingmin Tang, Xinlian Wang, Liang Yan, Zecheng Xiong, Xinghua Shi, Ge Bai, Huibiao Liu, Yuliang Li, Yuliang Zhao, Chunying Chen, Pengxu Qian
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
DNA methyltransferase 3A, a mutated gene associated with hematologic malignancies in age-related clonal haematopoiesis lacks targeted therapies. Here, the authors screen carbon nanomaterials and find graphdiyne oxide binds to mutant cells and disrupt
Externí odkaz:
https://doaj.org/article/ad94c52bd66b4f4090ae67d2fab038fa
Autor:
Jiadong Lin, Xiaofei Yang, Walter Kosters, Tun Xu, Yanyan Jia, Songbo Wang, Qihui Zhu, Mallory Ryan, Li Guo, Chengsheng Zhang, Charles Lee, Scott E. Devine, Evan E. Eichler, Kai Ye, Mark B. Gerstein, Ashley D. Sanders, Micheal C. Zody, Michael E. Talkowski, Ryan E. Mills, Jan O. Korbel, Tobias Marschall, Peter Ebert, Peter A. Audano, Bernardo Rodriguez-Martin, David Porubsky, Marc Jan Bonder, Arvis Sulovari, Jana Ebler, Weichen Zhou, Rebecca Serra Mari, Feyza Yilmaz, Xuefang Zhao, PingHsun Hsieh, Joyce Lee, Sushant Kumar, Tobias Rausch, Yu Chen, Zechen Chong, Katherine M. Munson, Mark J.P. Chaisson, Junjie Chen, Xinghua Shi, Aaron M. Wenger, William T. Harvey, Patrick Hansenfeld, Allison Regier, Ira M. Hall, Paul Flicek, Alex R. Hastie, Susan Fairely
Publikováno v:
Genomics, Proteomics & Bioinformatics, Vol 20, Iss 1, Pp 205-218 (2022)
Complex structural variants (CSVs) are genomic alterations that have more than two breakpoints and are considered as the simultaneous occurrence of simple structural variants. However, detecting the compounded mutational signals of CSVs is challengin
Externí odkaz:
https://doaj.org/article/513b1cf5af894e5190b4427f8d55b1a7
Publikováno v:
Polymer Testing, Vol 117, Iss , Pp 107847- (2023)
Epoxy resins are a class of viscoelastic hygroscopic polymers widely used in plastic packaged devices. Stress relaxation and yielding may occur in plastic packaged devices under thermal-hygro environments, which seriously affect the reliability of th
Externí odkaz:
https://doaj.org/article/06bc7c9718da4a73b117720b2aa9294b
Autor:
Junchao Xu, Kaiwei Wan, Hui Wang, Xinghua Shi, Jing Wang, Yi Zhong, Chao Gao, Yinlong Zhang, Guangjun Nie
Publikováno v:
ACS Central Science, Vol 7, Iss 11, Pp 1938-1948 (2021)
Externí odkaz:
https://doaj.org/article/8c36e9b22fef49028e14ed0d13e3223b
Autor:
Meng Song, Jonathan Greenbaum, Joseph Luttrell, Weihua Zhou, Chong Wu, Zhe Luo, Chuan Qiu, Lan Juan Zhao, Kuan-Jui Su, Qing Tian, Hui Shen, Huixiao Hong, Ping Gong, Xinghua Shi, Hong-Wen Deng, Chaoyang Zhang
Publikováno v:
Frontiers in Artificial Intelligence, Vol 5 (2022)
Genotype imputation has a wide range of applications in genome-wide association study (GWAS), including increasing the statistical power of association tests, discovering trait-associated loci in meta-analyses, and prioritizing causal variants with f
Externí odkaz:
https://doaj.org/article/1002be0b29d54fc69e4b78b22546b6d0