DNA-delivered monoclonal antibodies targeting the p53 R175H mutant epitope inhibit tumor development in mice

Autor: Dafei Chai, Xu Wang, Praveen Neeli, Shan Zhou, Xingfang Yu, Kanaga Sabapathy, Yong Li

Publikováno v: Genes and Diseases, Vol 11, Iss 4, Pp 100994- (2024)

The tumor suppressor p53 is the most common mutated gene in cancer, with the R175H as the most frequent p53 missense mutant. However, there are currently no approved targeted therapies or immunotherapies against mutant p53. Here, we characterized and

Externí odkaz: https://doaj.org/article/8c5ee228f9944b10af5c9877544ec0ec

3D porous acellular cartilage matrix scaffold with surface mediated sustainable release of TGF-β3 for cartilage engineering

Autor: Zhiyong Qian, Shuo Wang, Liyan Shen, Xin Liao, Yi-Xing Huang, Xingfang Yu, Linjie He

Publikováno v: Chinese Chemical Letters. 31:1797-1800

Acellular tissue matrix scaffolds are much closer to tissue’s complex natural structure and biological characteristics, thus assess great advantages in cartilage engineering. We used rabbit costal cartilage to prepare acellular microfilaments and f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::332d586fd42f7dc22880708d17a237d6
https://doi.org/10.1016/j.cclet.2020.01.039

Antibiotic-Loaded MMT/PLL-Based Coating on the Surface of Endosseous Implants to Suppress Bacterial Infections

Autor: Xin Liao, Hongwei Chen, Xingfang Yu

Publikováno v: International Journal of Nanomedicine

Xingfang Yu,1,* Xin Liao,2,* Hongwei Chen1 1Department of Orthopedics, The Affiliated Yiwu Hospital of Wenzhou Medical University, Yiwu, Zhejiang, 322000, People’s Republic of China; 2Department of Orthopedics, The Second Affiliated Hospital and Yu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f57102f3bd620caf084add8fafe5337d
https://pubmed.ncbi.nlm.nih.gov/33907402

Microporous polysaccharide multilayer coated BCP composite scaffolds with immobilised calcitriol promote osteoporotic bone regeneration both in vitro and in vivo

Autor: Qian Tang, Liyan Shen, Haiming Jin, Gang Wu, Changqing Zhang, Zhenzhong Zhu, Huazi Xu, Xingfang Yu, Zhi-Chao Hu, Gang Zheng, Haixiao Liu

Publikováno v: Theranostics
Tang, Q, Hu, Z, Jin, H, Zheng, G, Yu, X F, Wu, G, Liu, H, Zhu, Z, Xu, H, Zhang, C & Shen, L 2019, ' Microporous polysaccharide multilayer coated BCP composite scaffolds with immobilised calcitriol promote osteoporotic bone regeneration both in vitro and in vivo ', Theranostics, vol. 9, no. 4, pp. 1125-1143 . https://doi.org/10.7150/thno.29566
Theranostics, 9(4), 1125-1143. Ivyspring International Publisher

Incorporating a biomimetic coating and integrating osteoinductive biomolecules into basic bone substitutes are two common strategies to improve osteogenic capabilities in bone tissue engineering. Currently, the underlying mechanism of osteoporosis (O

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3748322a890771729ab1931d9bb278a
http://europepmc.org/articles/PMC6401415

Paeonol Inhibits IL-1β-Induced Inflammation via PI3K/Akt/NF-κB Pathways: In Vivo and Vitro Studies

Autor: Qian Tang, Zhenhua Feng, Jianshun Wang, Xiaoshan Guo, Xingfang Yu, Yiting Lou, Chenggui Wang, Wenhao Zheng

Publikováno v: Inflammation. 40:1698-1706

Paeonol, the main active component isolated from the root of Paeonia suffruticosa, has been reported to have anti-inflammatory properties. However, the effects of paeonol on osteoarthritis (OA) remain unclear. The aim of this study was to investigate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::198e1190069860b3ffabfd1cde1e4a80
https://doi.org/10.1007/s10753-017-0611-8