Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Xing-Lei Song"'
Autor:
Xin Qi, Jian-Fei Lu, Zi-Yue Huang, Yi-Jun Liu, Lu-Bing Cai, Xin-Lan Wen, Xing-Lei Song, Jian Xiong, Pei-Yi Sun, Hao Zhang, Ting-Ting Zhang, Xuan Zhao, Qin Jiang, Ying Li, Oleg Krishtal, Leng-Chen Hou, Michael X. Zhu, Tian-Le Xu
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Acidosis is a hallmark of ischemic stroke and a promising neuroprotective target for preventing neuronal injury. Previously, genetic manipulations showed that blockade of acid-sensing ion channel 1a (ASIC1a)-mediated acidotoxicity could dramatically
Externí odkaz:
https://doaj.org/article/d3732aac90b844198f196b204024ea4e
Autor:
Di-Shi Liu, Xing-Lei Song, Ming-Gang Liu, Jianfei Lu, Yu Huang, Jaepyo Jeon, Guofen Ma, Yong Li, Lucas Pozzo-Miller, Michael X. Zhu, Tian-Le Xu
Phospholipid-protein interaction is highly specialized at the membranous nanodomains and critical for membrane receptor signaling. Calcium-permeable acid-sensing ion channel isoform 1a (ASIC1a) is a major neuronal proton sensor that contributes to sy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e3046847b3f6efe2810fc1e6730131a3
https://doi.org/10.1101/2022.09.29.509830
https://doi.org/10.1101/2022.09.29.509830
Autor:
Michael X. Zhu, Nan-Jie Xu, Wei-Guang Li, Ming-Gang Liu, Di-Shi Liu, Xin Qi, Guang Yang, Min Qiang, Qian Li, Tian-Le Xu, Xing-Lei Song
Publikováno v:
Neuroscience Bulletin
Acid-sensing ion channels (ASICs), the main H+ receptors in the central nervous system, sense extracellular pH fluctuations and mediate cation influx. ASIC1a, the major subunit responsible for acid-activated current, is widely expressed in brain neur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0acac8fb5732748836fff3151beb55dc
https://doi.org/10.1007/s12264-020-00581-9
https://doi.org/10.1007/s12264-020-00581-9
Autor:
Haibo Shi, Kun Ni, Oleksandr Maximyuk, Oleg Krishtal, Xing-Lei Song, Hao-Song Shi, Lu-Yang Wang, Chun-Yan Li, Ke Lai, Xin Qi, Xiaoyan Li, Wan-Peng Li, Jia Fang, Shankai Yin, Tian-Le Xu, Fan Wang
Publikováno v:
Science Translational Medicine. 12
Neonatal hyperbilirubinemia is a common clinical condition that can lead to brain encephalopathy, particularly when concurrent with acidosis due to infection, ischemia, and hypoxia. The prevailing view is that acidosis increases the permeability of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7409f0cac03a47199a47474d59d53fa9
https://doi.org/10.1126/scitranslmed.aax1337
https://doi.org/10.1126/scitranslmed.aax1337
Autor:
Oleksandr Maximyuk, Oleg Krishtal, Hu-Song Li, Lujian Liao, Tingting Wang, Rui-Qi Wang, Tian-Le Xu, Michael X. Zhu, Xin Qi, Ming-Gang Liu, Ying Li, Xin-Yu Su, Hong Cao, Xing-Lei Song, Yu-Qiu Zhang, Houqin Fang
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 39(29)
Chronic pain is a serious debilitating disease for which effective treatment is still lacking. Acid-sensing ion channel 1a (ASIC1a) has been implicated in nociceptive processing at both peripheral and spinal neurons. However, whether ASIC1a also cont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fec39372115e041bab0876ee8203d4d
https://pubmed.ncbi.nlm.nih.gov/31101759
https://pubmed.ncbi.nlm.nih.gov/31101759
Publikováno v:
Journal of Molecular Endocrinology. 57:61-72
Cell adhesion to extracellular matrix (ECM) is controlled by multiple signaling molecules and intracellular pathways, and is pivotal for survival and growth of cells from most solid tumors. Our previous works demonstrated that dexamethasone (DEX) sig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edfdcbb46cc3393128dbdcf2105106de
https://doi.org/10.1530/jme-15-0142
https://doi.org/10.1530/jme-15-0142
Autor:
Xing Lei Song, Tian Le Xu, Michael X. Zhu, Ying Li, Qin Wang, Siyu Zhang, Qi Wang, Ti-Fei Yuan, Yan Jiao Wu, Wei Guang Li, Nan-Jie Xu, Qin Jiang
Publikováno v:
Science Advances
Learning to extinguish traumatic memory depends on fine-tuning of hippocampal-prefrontal connections via the ASIC1a channel.
Extinction of conditioned fear necessitates the dynamic involvement of hippocampus, medial prefrontal cortex (mPFC), and
Extinction of conditioned fear necessitates the dynamic involvement of hippocampus, medial prefrontal cortex (mPFC), and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d2373a83f4c190f8f8c36ef4d0a45b4
http://europepmc.org/articles/PMC6223961
http://europepmc.org/articles/PMC6223961
Autor:
Di Shi Liu, Yi Zhi Wang, Zhe Yu, Michael X. Zhu, Ying Li, Xing Lei Song, Tian Le Xu, Yan Jiao Wu, Wei Guang Li, Siyu Zhang, Nan-Jie Xu, Qin Jiang
Acid-sensing ion channel 1a (ASIC1a) is abundant in multiple brain regions, including the striatum, which serves as the input nucleus of the basal ganglia and is critically involved in procedural learning and motor memory. We investigated the functio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6abc8dc4350b3e3fd5296136a97081c5
https://europepmc.org/articles/PMC6324561/
https://europepmc.org/articles/PMC6324561/
Autor:
Qin Hu, Richard A. Lerner, Xue Dong, Lixia Zhao, Wanhui Hu, Guang Yang, Francesco Zonta, Qu Zhihu, Jie Li, Peixiang Ma, Tian-Le Xu, Chen Huang, Bei Yang, Xiao-Kun Zuo, Zheng Yu, Pingdong Tao, Jia Xie, Yan Nie, Wei-Guang Li, Damiano Buratto, Yi Zhang, Zhao Zha, Chao Yuan, Lili Liu, Xing-Lei Song, Min Qiang
Publikováno v:
Proceedings of the National Academy of Sciences. 115
Acid-sensing ion channels (ASICs) have emerged as important, albeit challenging therapeutic targets for pain, stroke, etc. One approach to developing therapeutic agents could involve the generation of functional antibodies against these channels. To
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd1dcd60418a631cab3b565659e26dd2
https://doi.org/10.1073/pnas.1807233115
https://doi.org/10.1073/pnas.1807233115
Autor:
Xiang Wang, Wen Jiang, Xing Lei Song, Yong Li, Michael X. Zhu, Tian Le Xu, Wei-Zheng Zeng, Bo Duan, Dong Wei, Di Shi Liu
Publikováno v:
The Journal of Neuroscience. 33:7066-7078
Acid-sensing ion channels (ASICs) are proton-gated cation channels widely expressed in the peripheral and CNSs, which critically contribute to a variety of pathophysiological conditions that involve tissue acidosis, such as ischemic stroke and epilep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35ee16b3777d785b19a269e42b97ee7c
https://doi.org/10.1523/jneurosci.5206-12.2013
https://doi.org/10.1523/jneurosci.5206-12.2013