Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Xing-Hong Leng"'
Autor:
Christian Bjørbæk, Xing-Hong Leng, José P. Silva, Sarah Greeley, Kevin M. Gamber, Nicholas Huntoon, Lihong Huo
Publikováno v:
Cell Metabolism. 9:537-547
SummaryLeptin plays a pivotal role in regulation of energy balance. Via unknown central pathways, leptin also affects peripheral glucose homeostasis and locomotor activity. We hypothesized that, specifically, pro-opiomelanocortin (POMC) neurons media
Publikováno v:
Thrombosis Research. 123:93-99
The platelet-collagen interaction is a critical early event in arterial thrombus formation, and platelet GPVI is the major activating receptor for collagen. We have previously used a mouse model to demonstrate that the estrogen effects on platelets d
Autor:
Paul F. Bray, Xing-Hong Leng
Publikováno v:
Drug Discovery Today: Disease Mechanisms. 2:85-91
There is evidence that platelets from women are hyperreactive compared to platelets from men, that endogenous estrogen regulates platelet reactivity, that estrogen therapies modulate platelets response to agonists, and that estrogen acts directly on
Publikováno v:
Journal of Biological Chemistry. 273:6717-6723
We have previously shown that mutations in buried charged residues in the last two transmembrane helices of Vph1p (the 100-kDa subunit of the yeast V-ATPase) inhibit proton transport and ATPase activity (Leng, X. H., Manolson, M., Liu, Q., and Forgac
Publikováno v:
Circulation Research. 97:415-417
Clinical trials have shown estrogen replacement therapy (ERT) is associated with adverse arterial vascular events. Arterial thrombosis is initiated by platelet activation, but the in vivo effects of estrogens on platelet function are not well underst
Autor:
Michael B. Wheeler, H. Yoo-Warren, Y. Tanizawa, Aubrey E. Boyd, Xing-Hong Leng, Joseph S. Dillon, Brooke Ligon, D. U. Rabin, M. A. Permutt
Publikováno v:
Endocrinology. 133:1907-1910
Truncated forms of glucagon-like peptide-1 are the most potent endogenous stimuli of insulin secretion and have powerful antidiabetogenic effects. To determine the structure and coupling mechanisms of the human GLP-1 receptor we have isolated two pan
Publikováno v:
Scopus-Elsevier
In man, glucagon-like peptide-I-(7-37) [GLP-I-(7-37)] is the most potent endogenous insulin-stimulating hormone. Although GLP-I-(7-37)-stimulated insulin secretion from the beta-cell is associated with an increase in cAMP accumulation, little is know
Publikováno v:
Endocrinology. 132:94-100
Using the glucose-responsive hamster beta-cell line (hamster insulin tumor cells), we examined the cellular mechanisms by which gastric inhibitory polypeptide (GIP) and glucagon-like peptide I(7-37) (GLP-I) potentiate glucose-stimulated insulin secre
Autor:
Paul F. Bray, Xing-Hong Leng, Tong Tong Li, Susana Larrucea, Wei Zhang, José A. López, Song Yun Hong
Publikováno v:
Arteriosclerosis, thrombosis, and vascular biology. 24(2)
Objective— It has been reported that women fare worse after ischemic coronary events, but the mechanisms remain unclear. Because platelets play a central role in the formation of occlusive thrombi at sites of ruptured atherosclerotic plaques, we st
Publikováno v:
The Journal of biological chemistry. 274(21)
The membrane topography of the yeast vacuolar proton-translocating ATPase a subunit (Vph1p) has been investigated using cysteine-scanning mutagenesis. A Cys-less form of Vph1p lacking the seven endogenous cysteines was constructed and shown to have 8