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Pyrazolamide derivatives inhibit α-Synuclein aggregation, disaggregate preformed fibers, and reduce inclusion formation in neuron cells.

Autor: Xing LZ; Green Catalysis Center, College of Chemistry, Zhengzhou University, Daxue Road 75, 450052, Zhengzhou, China., Zhang W; Green Catalysis Center, College of Chemistry, Zhengzhou University, Daxue Road 75, 450052, Zhengzhou, China., Zhao YD; Green Catalysis Center, College of Chemistry, Zhengzhou University, Daxue Road 75, 450052, Zhengzhou, China., Xu J; Department of Pharmacology, School of Basic Medical Science, Neuroscience Research Institute, Academy of Medical Sciences, Zhengzhou University, Kexue Road 100, 450001, Zhengzhou, China. Electronic address: xuji@zzu.edu.cn., Zhang YX; Green Catalysis Center, College of Chemistry, Zhengzhou University, Daxue Road 75, 450052, Zhengzhou, China. Electronic address: zhangyx@zzu.edu.cn.

Publikováno v: European journal of medicinal chemistry [Eur J Med Chem] 2024 Mar 15; Vol. 268, pp. 116198. Date of Electronic Publication: 2024 Feb 06.

The potential of Rhein's aromatic amines for Parkinson's disease prevention and treatment: α-Synuclein aggregation inhibition and disaggregation of preformed fibers.

Autor: Zhang W; Green Catalysis Center, College of Chemistry, Zhengzhou University, Daxue Road 75, 450052 Zhengzhou, China., Liu W; Green Catalysis Center, College of Chemistry, Zhengzhou University, Daxue Road 75, 450052 Zhengzhou, China., Zhao YD; Green Catalysis Center, College of Chemistry, Zhengzhou University, Daxue Road 75, 450052 Zhengzhou, China., Xing LZ; Green Catalysis Center, College of Chemistry, Zhengzhou University, Daxue Road 75, 450052 Zhengzhou, China., Xu J; Department of Pharmacology, School of Basic Medical Science, Zhengzhou University, Kexue Road 100, 450001 Zhengzhou, China; Neuroscience Research Institute, Academy of Medical Sciences, Zhengzhou University, Kexue Road 100, 450001 Zhengzhou, China. Electronic address: xuji@zzu.edu.cn., Li RJ; Green Catalysis Center, College of Chemistry, Zhengzhou University, Daxue Road 75, 450052 Zhengzhou, China. Electronic address: liruijun@zzu.edu.cn., Zhang YX; Green Catalysis Center, College of Chemistry, Zhengzhou University, Daxue Road 75, 450052 Zhengzhou, China. Electronic address: zhangyx@zzu.edu.cn.

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2024 Jan 01; Vol. 97, pp. 129564. Date of Electronic Publication: 2023 Nov 22.

Hybrids of polyphenolic/quinone acids, the potential preventive and therapeutic drugs for PD: Disaggregate α-Syn fibrils, inhibit inclusions, and repair damaged neurons in mice.

Autor: Lü MH; Green Catalysis Center, College of Chemistry, Zhengzhou University, Daxue Road 75, Zhengzhou, 450052, China; Department of Obstetrics and Gynecology, The Second Affiliated Hospital, Zhengzhou University, Zhengzhou, 450014, China., Wang ZP; Green Catalysis Center, College of Chemistry, Zhengzhou University, Daxue Road 75, Zhengzhou, 450052, China., Xing LZ; Green Catalysis Center, College of Chemistry, Zhengzhou University, Daxue Road 75, Zhengzhou, 450052, China., Zhang W; Green Catalysis Center, College of Chemistry, Zhengzhou University, Daxue Road 75, Zhengzhou, 450052, China., Han F; Green Catalysis Center, College of Chemistry, Zhengzhou University, Daxue Road 75, Zhengzhou, 450052, China., Huang GL; Green Catalysis Center, College of Chemistry, Zhengzhou University, Daxue Road 75, Zhengzhou, 450052, China., Liu W; Green Catalysis Center, College of Chemistry, Zhengzhou University, Daxue Road 75, Zhengzhou, 450052, China., Zhang YX; Green Catalysis Center, College of Chemistry, Zhengzhou University, Daxue Road 75, Zhengzhou, 450052, China. Electronic address: zhangyx@zzu.edu.cn., Xu J; School of Basic Medical Science, Neuroscience Research Institute, Academy of Medical Sciences, Zhengzhou University, Kexue Road 100, Zhengzhou, 45000, China. Electronic address: xuji@zzu.edu.cn., Cui J; Department of Obstetrics and Gynecology, The Second Affiliated Hospital, Zhengzhou University, Zhengzhou, 450014, China. Electronic address: jinquan_cui@163.com.

Publikováno v: European journal of medicinal chemistry [Eur J Med Chem] 2023 Mar 05; Vol. 249, pp. 115122. Date of Electronic Publication: 2023 Jan 18.