Tyrosine phosphorylation of WIP releases bound WASP and impairs podosome assembly in macrophages

Autor: Inés M. Antón, Vineetha Vijayakumar, Laura M. Machesky, Gareth E. Jones, Yolanda Calle, James Monypenny, Xing Judy Chen, Adrian J. Thrasher, Sergio Lilla

Publikováno v: Journal of Cell Science
Vijayakumar, V, Monypenny, J, Chen, X J, Machesky, L, Lilla, S, Thrasher, A J, Antón, I M, Calle, Y & Jones, G E 2015, ' Tyrosine phosphorylation of WIP releases bound WASP and impairs podosome assembly in macrophages ', Journal of Cell Science, vol. 128, no. 2, pp. 251-265 . https://doi.org/10.1242/jcs.154880

Podosomes are integrin-containing adhesion structures commonly found in migrating leukocytes of the monocytic lineage. The actin cytoskeletal organisation of podosomes is based on a WASP- and Arp2/3-mediated mechanism. WASP also associates with a sec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd928c9ac549eb2f2f3473f3f620ebae
http://europepmc.org/articles/PMC4294773

Ena/VASP Proteins Cooperate with the WAVE Complex to Regulate the Actin Cytoskeleton

Autor: Sven Bogdan, Raiko Stephan, Theresa Higgins, Michael K. Rosen, Baoyu Chen, Morag C. Martin, Xing Judy Chen, Anna Julia Squarr, David J. Barry, Michael Way

Publikováno v: Developmental Cell

Summary Ena/VASP proteins and the WAVE regulatory complex (WRC) regulate cell motility by virtue of their ability to independently promote actin polymerization. We demonstrate that Ena/VASP and the WRC control actin polymerization in a cooperative ma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e300ddf31b57554324a09a95293f42e