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Genome-Derived Cytosolic DNA Mediates Type I Interferon-Dependent Rejection of B Cell Lymphoma Cells
Autor:
Yu J. Shen, Nina Le Bert, Anuja A. Chitre, Christine Xing’Er Koo, Xing H. Nga, Samantha S.W. Ho, Muznah Khatoo, Nikki Y. Tan, Ken J. Ishii, Stephan Gasser
Publikováno v:
Cell Reports, Vol 11, Iss 3, Pp 460-473 (2015)
The DNA damage response (DDR) induces the expression of type I interferons (IFNs), but the underlying mechanisms are poorly understood. Here, we show the presence of cytosolic DNA in different mouse and human tumor cells. Treatment of cells with geno
Externí odkaz:
https://doaj.org/article/b64878490de44c35adf2fa2aec76582d
