Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Xinfa, Bai"'
Autor:
Jiahao Qiu, Xinfa Bai, Wenjing Zhang, Mingxu Ma, Wenyan Wang, Ye Liang, Hongbo Wang, Jingwei Tian, Pengfei Yu
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Triple negative breast cancer (TNBC) is a subtype of breast cancer with significant malignancy and poor prognosis but effective treatments are limited. Given the critical role of CDK4/6 in cell cycle and the apparent success of CDK4/6 inhibitors agai
Externí odkaz:
https://doaj.org/article/f46c872831584686a9572f376dd84d61
Publikováno v:
Chemistry Central Journal, Vol 12, Iss 1, Pp 1-8 (2018)
Abstract Background Tubulysins family is a kind of natural compound with potent, antitumor activity. To simplify the synthesis route and find new antitumor compounds is becoming a hotspot of research recent years. Results Starting from 3-nitrobenzoic
Externí odkaz:
https://doaj.org/article/acde3b78de7644d1967dafa97d1b3a17
Autor:
Jing Lu, Hui Lei, Xinfa Bai, Wenyan Wang, Chunjiao Liu, Yifei Yang, Fangxia Zou, Guangying Du, Xin Wang, Cuicui Sun, Lisha Yu, Mingxu Ma, Liang Ye, Hongbo Wang, Jingwei Tian, jianzhao zhang
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d0af0f7e92ffd29bde33280a56b064e1
https://doi.org/10.2139/ssrn.4329585
https://doi.org/10.2139/ssrn.4329585
Autor:
Wenyan Wang, Shilan Lin, Guangying Du, Xinfa Bai, Jing Lu, Liang Ye, Hongbo Wang, Rui Zhang, Jingwei Tian
Publikováno v:
Future medicinal chemistry. 14(13)
Aim: To separate and evaluate 9-cyclopropylmethoxy-dihydrotetrabenazine (13a) and its stereoisomers for their high affinity for vesicular monoamine transporter-2 (VMAT2). Method: Stereoisomers of 13a were separated and configurations were ascertained
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f1ca040716d7dd422005e9588091e43
https://pubmed.ncbi.nlm.nih.gov/35638444
https://pubmed.ncbi.nlm.nih.gov/35638444
Publikováno v:
Biological and Pharmaceutical Bulletin. 42:873-876
To establish a synthetic route to d3-poziotinib hydrochloride. Treatment of 4-chloro-7-hydroxyquinazolin-6-yl pivalate (1) with d3-methyliodide afforded the etherization product, which reacted with 3,4-dichloro-2-fluoroaniline to generate the key int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b6a9dfe752a1d18934621b081db42b6
https://doi.org/10.1248/bpb.b19-00153
https://doi.org/10.1248/bpb.b19-00153
Publikováno v:
Biologicalpharmaceutical bulletin. 42(6)
To establish a synthetic route to d3-poziotinib hydrochloride. Treatment of 4-chloro-7-hydroxyquinazolin-6-yl pivalate (1) with d3-methyliodide afforded the etherization product, which reacted with 3,4-dichloro-2-fluoroaniline to generate the key int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::10fb8e56be9d49f8a4fa31cab4b8fcc0
https://pubmed.ncbi.nlm.nih.gov/31155586
https://pubmed.ncbi.nlm.nih.gov/31155586
Publikováno v:
Chemistry Central Journal
Chemistry Central Journal, Vol 12, Iss 1, Pp 1-8 (2018)
Chemistry Central Journal, Vol 12, Iss 1, Pp 1-8 (2018)
Background Tubulysins family is a kind of natural compound with potent, antitumor activity. To simplify the synthesis route and find new antitumor compounds is becoming a hotspot of research recent years. Results Starting from 3-nitrobenzoic acid, af
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85f8b3730b7278921af697972213654e
http://europepmc.org/articles/PMC6768038
http://europepmc.org/articles/PMC6768038
Publikováno v:
Mini reviews in medicinal chemistry. 18(13)
Sirtuins are a family of NAD+-dependent deacetylases (class III histone deacetylases). Seven mammalian sirtuins, SIRT1-7, are identified, as the functions and locations differ greatly. SIRT1 and SIRT2 locate in nucleus and cytoplasm, while SIRT3-5 in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf6bcb39e099a683f6524eed72c90d57
https://pubmed.ncbi.nlm.nih.gov/27334466
https://pubmed.ncbi.nlm.nih.gov/27334466
Publikováno v:
Chemistry Central Journal; 2015, Vol. 9 Issue 1, p1-4, 4p
Publikováno v:
Chemistry Central Journal
A concise route for the synthesis of Fingolimod is reported. Starting from n-octylbenzene and 3-nitropropionic acid, a sequence of reactions consisting of Friedel-Crafts acylation, reduction, and double Henry reaction, followed by hydrogenation were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9026fac43598f66234288d2d9416e163