Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Xinbin Gu"'
Autor:
Guiqin Xie, Liang Shan, Cuicui Yang, Yuanyi Liu, Xiaowu Pang, Shaolei Teng, Tzyy-Choou Wu, Xinbin Gu
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract The innate immune stimulator of interferon genes (STING) pathway is known to activate type I interferons (IFN-I) and participate in generating antitumor immunity. We previously produced hDT806, a recombinant diphtheria immunotoxin, and demon
Externí odkaz:
https://doaj.org/article/4c29c2a9b100442dad3224f3dddb2da3
Publikováno v:
Public Health in Practice, Vol 3, Iss , Pp 100239- (2022)
Objectives: Public understanding of human papillomavirus (HPV)-associated oropharyngeal cancer (OPC) is minimally understood. Therefore uncovering communication gaps between the public and healthcare professionals regarding this disease is vital. Soc
Externí odkaz:
https://doaj.org/article/a693ed9c5a584b70a16b82b50d7613be
Publikováno v:
Biology, Vol 11, Iss 4, p 486 (2022)
Over 90% of head and neck squamous cell carcinoma (HNSCC) overexpresses the epidermal growth factor receptor (EGFR). However, the EGFR-targeted monotherapy response rate only achieves 10–30% in HNSCC. Recombinant immunotoxin (RIT) often consists of
Externí odkaz:
https://doaj.org/article/85bc0b1cf28c48669fdaaccfc12a3141
Autor:
Shengfeng Wan, Shengbo Cao, Xugang Wang, Yanfei Zhou, Weidong Yan, Xinbin Gu, Tzyy-Choou Wu, Xiaowu Pang
Publikováno v:
Vaccines, Vol 9, Iss 4, p 338 (2021)
The flavivirus Zika (ZIKV) has emerged as a global threat, making the development of a ZIKV vaccine a priority. While live-attenuated vaccines are known to induce long-term immunity but reduced safety, inactivated vaccines exhibit a weaker immune res
Externí odkaz:
https://doaj.org/article/9444a9fec1e445168b07597c4ae361c3
Autor:
Belinda Hauser, Yuan Zhao, Xiaowu Pang, Zhiqiang Ling, Ernest Myers, Paul Wang, Joseph Califano, Xinbin Gu
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0116321 (2015)
Incidence of head and neck squamous cell carcinoma (HNSCC) has continuously increased in past years while its survival rate has not been significantly improved. There is a critical need to better understand the genetic regulation of HNSCC tumorigenes
Externí odkaz:
https://doaj.org/article/69870ca87678463f8923ab9bb7ee32ee
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e29750 (2012)
Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a newly identified tumor suppressor that is frequently downregulated in a variety of human cancers. Our previous work revealed that the low expression of CHD5 in colorectal cancer is correlated wi
Externí odkaz:
https://doaj.org/article/c1ea898f91ca4ebbbb0e2dc939bf9db8
Autor:
Liang Shan, Yubin Hao, Songping Wang, Alexandru Korotcov, Renshu Zhang, Tongxin Wang, Joseph Califano, Xinbin Gu, Rajagopalan Sridhar, Zaver M. Bhujwalla, Paul C. Wang
Publikováno v:
Molecular Imaging, Vol 7 (2008)
Transferrin receptor (TfR) is overexpressed in human head and neck squamous cell carcinomas (HNSCCs). This study was carried out to investigate the feasibility of imaging HNSCC by targeting TfR using near-infrared fluorescent transferrin conjugate (T
Externí odkaz:
https://doaj.org/article/1972cadda0fb448e91843fd3a2fe25b0
Autor:
Shengbo Cao, Xinbin Gu, Xiaowu Pang, Tzyy Choou Wu, Yanfei Zhou, Shengfeng Wan, Weidong Yan, Xugang Wang
Publikováno v:
Virology
Zika virus (ZIKV) is a mosquito-borne flavivirus that replicates in both vertebrate and insect cells, whereas insect-specific flaviviruses (ISF) replicate only in insect cells. We sought to convert ZIKV, from a dual-tropic flavivirus, into an insect-
Autor:
Dana R. Cadet, Namita Kumari, Wolfgang Peti, Meng S. Choy, Ayyiliath M. Sajith, Xionghao Lin, Sergei Nekhai, Amol A. Kulkarni, Xinbin Gu, Asrar Ahmad, Andrey Ivanov, Songping Wang
Publikováno v:
ACS Infectious Diseases. 6:3190-3211
Combination antiretroviral therapy (cART) suppresses human immunodeficiency virus-1 (HIV-1) replication but is unable to permanently eradicate HIV-1. Importantly, cART does not target HIV-1 transcription, which is reactivated in latently infected res
Publikováno v:
Cancers; Volume 14; Issue 7; Pages: 1714
Hepatocellular carcinoma (HCC) is a lethal malignancy with high mortality. The inhibition of cyclin-dependent kinase 7 (CDK7) activity has shown therapeutic efficacy in HCC. However, the underlying molecular mechanisms remain elusive. Here, we show t