Zobrazeno 1 - 10
of 312
pro vyhledávání: '"Xinan WANG"'
Publikováno v:
Nuclear Engineering and Technology, Vol 56, Iss 10, Pp 4397-4403 (2024)
The multi-dimensional thermal-hydraulic phenomena in the downcomer of advanced pressurized water reactor with direct vessel injection system are the key points for the safety analysis during a loss of coolant accident. In order to improve the accurac
Externí odkaz:
https://doaj.org/article/10a03837179846f8a33f9df17227e538
Autor:
Marie-Julie Nokin, Alessia Mira, Enrico Patrucco, Biagio Ricciuti, Sophie Cousin, Isabelle Soubeyran, Sonia San José, Serena Peirone, Livia Caizzi, Sandra Vietti Michelina, Aurelien Bourdon, Xinan Wang, Daniel Alvarez-Villanueva, María Martínez-Iniesta, August Vidal, Telmo Rodrigues, Carmen García-Macías, Mark M. Awad, Ernest Nadal, Alberto Villanueva, Antoine Italiano, Matteo Cereda, David Santamaría, Chiara Ambrogio
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Selective KRASG12C inhibitors have been developed to covalently lock the oncogene in the inactive GDP-bound state. Two of these molecules, sotorasib and adagrasib, are approved for the treatment of adult patients with KRASG12C-mutated previo
Externí odkaz:
https://doaj.org/article/720b0c9c9a024f38961f97cf298e776d
Autor:
Biagio Ricciuti, MD, PhD, Arielle Elkrief, MD, Jessica Lin, MD, Jianjun Zhang, MD, Joao V. Alessi, MD, Giuseppe Lamberti, MD, PhD, Malini Gandhi, MD, Alessandro Di Federico, MD, Federica Pecci, MD, Xinan Wang, PhD, Maisam Makarem, MD, PhD, Cassio Murilo Hidalgo Filho, MD, Teresa Gorria, MD, Arushi Saini, BS, Cindy Pabon, MD, James Lindsay, PhD, Kathleen L. Pfaff, PhD, Emma L. Welsh, BS, Mizuki Nishino, MD, Lynette M. Sholl, MD, Scott Rodig, MD, Saadettin Kilickap, MD, Petra Rietschel, MD, Debra AG. McIntyre, PhD, Jean-Francois Pouliot, MD, Mehmet Altan, MD, Justin F. Gainor, MD, John V. Heymach, MD, Adam J. Schoenfeld, MD, Mark M. Awad, MD, PhD
Publikováno v:
JTO Clinical and Research Reports, Vol 5, Iss 9, Pp 100675- (2024)
Introduction: Responses to first-line programmed cell death protein 1 inhibition vary among patients with metastatic NSCLC and a programmed death-ligand 1 (PD-L1) tumor proportion score (TPS) greater than or equal to 50%. We previously reported impro
Externí odkaz:
https://doaj.org/article/b469726a5a6d43d08be740aa9e8f7bc9
Autor:
Xinan Wang, Kangcheng Hou, Biagio Ricciuti, Joao V. Alessi, Xihao Li, Federica Pecci, Rounak Dey, Jia Luo, Mark M. Awad, Alexander Gusev, Xihong Lin, Bruce E. Johnson, David C. Christiani
Publikováno v:
HGG Advances, Vol 5, Iss 3, Pp 100320- (2024)
Summary: The KRAS mutation is the most common oncogenic driver in patients with non-small cell lung cancer (NSCLC). However, a detailed understanding of how self-reported race and/or ethnicity (SIRE), genetically inferred ancestry (GIA), and their in
Externí odkaz:
https://doaj.org/article/872f42da70b04727916e504d972d5581
Autor:
Xinan Wang, Ziwei Zhang, Yi Ding, Tony Chen, Lorelei Mucci, Demetrios Albanes, Maria Teresa Landi, Neil E. Caporaso, Stephen Lam, Adonina Tardon, Chu Chen, Stig E. Bojesen, Mattias Johansson, Angela Risch, Heike Bickeböller, H-Erich Wichmann, Gadi Rennert, Susanne Arnold, Paul Brennan, James D. McKay, John K. Field, Sanjay S. Shete, Loic Le Marchand, Geoffrey Liu, Angeline S. Andrew, Lambertus A. Kiemeney, Shan Zienolddiny-Narui, Annelie Behndig, Mikael Johansson, Angie Cox, Philip Lazarus, Matthew B. Schabath, Melinda C. Aldrich, Rayjean J. Hung, Christopher I. Amos, Xihong Lin, David C. Christiani
Publikováno v:
Genome Medicine, Vol 16, Iss 1, Pp 1-11 (2024)
Abstract Background Although polygenic risk score (PRS) has emerged as a promising tool for predicting cancer risk from genome-wide association studies (GWAS), the individual-level accuracy of lung cancer PRS and the extent to which its impact on sub
Externí odkaz:
https://doaj.org/article/f2a83eace6cb48e6be31892d21e98222
Publikováno v:
Zhongguo Jianchuan Yanjiu, Vol 19, Iss Supp1, Pp 1-9 (2024)
ObjectivesAs the core system of an unmanned surface vehicle, the autonomous control system (ACS) is responsible for coordinating other systems to achieve combat missions, which is the key to unmanned surface ship technology. MethodsFirst, based on th
Externí odkaz:
https://doaj.org/article/5d7650af09ec420e83cacc41227d909b
Autor:
Zhe Hong, Chengdang Xu, Shengfeng Zheng, Xinan Wang, Yiran Tao, Yao Tan, Guowen Lin, Denglong Wu, Dingwei Ye
Publikováno v:
Cell Death Discovery, Vol 9, Iss 1, Pp 1-12 (2023)
Abstract Nucleophosmin 1 (NPM1) is a multifunctional protein that promotes tumor progression in various cancers and is associated with a poor prognosis of prostate cancer (PCa). However, the mechanism by which NPM1 exerts its malignant potential in P
Externí odkaz:
https://doaj.org/article/c7ecc358617c415e97bbac52db47f0fb
Autor:
Joao V. Alessi, Biagio Ricciuti, Xinan Wang, Federica Pecci, Alessandro Di Federico, Giuseppe Lamberti, Arielle Elkrief, Scott J. Rodig, Emily S. Lebow, Jordan E. Eicholz, Maria Thor, Andreas Rimner, Adam J. Schoenfeld, Jamie E. Chaft, Bruce E. Johnson, Daniel R. Gomez, Mark M. Awad, Narek Shaverdian
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Although concurrent chemoradiation (CRT) and durvalumab consolidation has become a standard treatment for stage III non-small cell lung cancer (NSCLC), clinicopathologic and genomic factors associated with its efficacy remain poorly characte
Externí odkaz:
https://doaj.org/article/1cb0d71dba954b7a82afb042b77b3eda
Autor:
Zhifeng Liu, Haowen Chang, Fei Xu, Haichi Zhao, Liguang Zhu, Zhibin Sun, Mingchao Yang, Xinan Wang, Aijun Ma
Publikováno v:
Aquaculture Reports, Vol 33, Iss , Pp 101804- (2023)
The feed conversion rate (FCR) is a crucial economic trait in aquaculture fish, as feed costs account for the vast majority of aquaculture costs. Given the importance of this trait, there have little efforts to unravel the genomic architecture of FCR
Externí odkaz:
https://doaj.org/article/583085e196a641e59a1b41f00a26537c
Autor:
Yuming Sun, Stephen Salerno, Xinwei He, Ziyang Pan, Eileen Yang, Chinakorn Sujimongkol, Jiyeon Song, Xinan Wang, Peisong Han, Jian Kang, Michael W. Sjoding, Shruti Jolly, David C. Christiani, Yi Li
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract As portable chest X-rays are an efficient means of triaging emergent cases, their use has raised the question as to whether imaging carries additional prognostic utility for survival among patients with COVID-19. This study assessed the impo
Externí odkaz:
https://doaj.org/article/c8f7d7a383e349d6ad44a022acc494e8