Zobrazeno 1 - 10
of 107
pro vyhledávání: '"Xin-yun Lu"'
Autor:
Guo Xiang, Xia Liu, Jiangong Wang, Shunshun Lu, Meng Yu, Yuhan Zhang, Bin Sun, Bin Huang, Xin-Yun Lu, Xingang Li, Di Zhang
Publikováno v:
Translational Psychiatry, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract The dentate gyrus (DG) of the hippocampus encodes contextual information associated with fear, and cell activity in the DG is required for acquisition and extinction of contextual fear. However, the underlying molecular mechanisms are not fu
Externí odkaz:
https://doaj.org/article/d1a62f87ae4d49a293ffef6cb846e09b
Alterations in Alzheimer's disease microglia transcriptome might be involved in bone pathophysiology
Autor:
Mohini Gharpure, Sagar Vyavahare, Pankaj Ahluwalia, Sonu Kumar Gupta, Tae Jin Lee, Jayant Lohakare, Ravindra Kolhe, Yun Lei, Ferenc Deak, Xin-Yun Lu, Carlos M. Isales, Sadanand Fulzele
Publikováno v:
Neurobiology of Disease, Vol 191, Iss , Pp 106404- (2024)
Aging is a major risk factor for multiple chronic disorders in the elderly population, including Alzheimer's disease (AD) and Osteoporosis. AD is a progressive neurodegenerative disease characterized by memory loss. In addition to dementia, several s
Externí odkaz:
https://doaj.org/article/f1dd5bb06bd34c81b1c6c662ce6b19fd
Autor:
Praneet Veerapaneni, Brandee Goo, Samah Ahmadieh, Hong Shi, David S. Kim, Mourad Ogbi, Stephen Cave, Ronnie Chouhaita, Nicole Cyriac, David J. Fulton, Alexander D. Verin, Weiqin Chen, Yun Lei, Xin-Yun Lu, Ha Won Kim, Neal L. Weintraub
Publikováno v:
Biomolecules, Vol 14, Iss 4, p 494 (2024)
Histone deacetylase (HDAC) 9 is a negative regulator of adipogenic differentiation, which is required for maintenance of healthy adipose tissues. We reported that HDAC9 expression is upregulated in adipose tissues during obesity, in conjunction with
Externí odkaz:
https://doaj.org/article/4f86865224ed43ec834dcb37d6130824
Autor:
Eunice W.M. Chin, Qi Ma, Hongyu Ruan, Camille Chin, Aditya Somasundaram, Chunling Zhang, Chunyu Liu, Martin D. Lewis, Melissa White, Tracey L. Smith, Malcolm Battersby, Wei-Dong Yao, Xin-Yun Lu, Wadih Arap, Julio Licinio, Ma-Li Wong
Publikováno v:
JCI Insight, Vol 7, Iss 14 (2022)
Synaptic dysfunction is a manifestation of several neurobehavioral and neurological disorders. A major therapeutic challenge lies in uncovering the upstream regulatory factors controlling synaptic processes. Plant homeodomain (PHD) finger proteins ar
Externí odkaz:
https://doaj.org/article/d81390da89e0491ca883d1a0e915b4cc
Autor:
Nam-Shik Kim, Zhexing Wen, Jing Liu, Ying Zhou, Ziyuan Guo, Chongchong Xu, Yu-Ting Lin, Ki-Jun Yoon, Junhyun Park, Michelle Cho, Minji Kim, Xinyuan Wang, Huimei Yu, Srilatha Salamuru, Kimberly M. Christian, Kuei-sen Hsu, Menghang Xia, Weidong Li, Christopher A. Ross, Russell L. Margolis, Xin-Yun Lu, Hongjun Song, Guo-li Ming
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Previous work has shown in iPSC derived neurons that synaptic impairments are associated with a 4bp DISC1 deletion. Here the authors demonstrate a role for the PDE4 signalling pathway in these synaptic impairments.
Externí odkaz:
https://doaj.org/article/a1c93081300b4869a2a2b16a518720f6
Autor:
Avirup Guha, Xiaoling Wang, Ryan A. Harris, Anna-Gay Nelson, David Stepp, Zachary Klaassen, Priyanka Raval, Jorge Cortes, Steven S. Coughlin, Vladimir Y. Bogdanov, Justin X. Moore, Nihar Desai, D. Douglas Miller, Xin-Yun Lu, Ha Won Kim, Neal L. Weintraub
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 8 (2021)
Cardiovascular disease (CVD) and cancer often occur in the same individuals, in part due to the shared risk factors such as obesity. Obesity promotes adipose inflammation, which is pathogenically linked to both cardiovascular disease and cancer. Comp
Externí odkaz:
https://doaj.org/article/fd12bd3ee35b48d983607c84dafa2a19
Autor:
Brandee Goo, Samah Ahmadieh, Abdalrahman Zarzour, Nicole K. H. Yiew, David Kim, Hong Shi, Jacob Greenway, Stephen Cave, Jenny Nguyen, Swetha Aribindi, Mark Wendolowski, Praneet Veerapaneni, Mourad Ogbi, Weiqin Chen, Yun Lei, Xin-Yun Lu, Ha Won Kim, Neal L. Weintraub
Publikováno v:
Cells, Vol 11, Iss 17, p 2698 (2022)
Obesity is a major risk factor for both metabolic and cardiovascular disease. We reported that, in obese male mice, histone deacetylase 9 (HDAC9) is upregulated in adipose tissues, and global deletion of HDAC9 protected against high fat diet (HFD)-in
Externí odkaz:
https://doaj.org/article/cada86bb8eb44d15aa06b99fd2eebe80
Autor:
Jacob Greenway, Nicole Gilreath, Sagar Patel, Tetsuo Horimatsu, Mary Moses, David Kim, Lauren Reid, Mourad Ogbi, Yang Shi, Xin-Yun Lu, Mrinal Shukla, Richard Lee, Yuqing Huo, Lufei Young, Ha Won Kim, Neal L. Weintraub
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 7 (2020)
Introduction: Abdominal aortic aneurysms (AAA) are characterized by localized inflammation, extracellular matrix degradation, and apoptosis of smooth muscle cells, which together lead to progressive and irreversible aortic dilation. Major risk factor
Externí odkaz:
https://doaj.org/article/bc23fba1efd343bda54600bd5b5c0a2b
Autor:
Nam-Shik Kim, Zhexing Wen, Jing Liu, Ying Zhou, Ziyuan Guo, Chongchong Xu, Yu-Ting Lin, Ki-Jun Yoon, Junhyun Park, Michelle Cho, Minji Kim, Xinyuan Wang, Huimei Yu, Srilatha Sakamuru, Kimberly M. Christian, Kuei-sen Hsu, Menghang Xia, Weidong Li, Christopher A. Ross, Russell L. Margolis, Xin-Yun Lu, Hongjun Song, Guo-li Ming
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-1 (2021)
https://doi.org/10.1038/s41467-021-23263-0
Externí odkaz:
https://doaj.org/article/d5fbb710385541b4bb123850e7c40ecb
Autor:
Xing Fang, Yuting Chen, Jiangong Wang, Ziliang Zhang, Yu Bai, Kirstyn Denney, Lin Gan, Ming Guo, Neal L. Weintraub, Yun Lei, Xin-Yun Lu
Publikováno v:
Molecular Psychiatry. 28:1365-1382
Chronic stress exposure induces maladaptive behavioral responses and increases susceptibility to neuropsychiatric conditions. However, specific neuronal populations and circuits that are highly sensitive to stress and trigger maladaptive behavioral r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c06bbbeeafb0adc9fb1927cbb494b18c
https://doi.org/10.1038/s41380-022-01872-5
https://doi.org/10.1038/s41380-022-01872-5