Zobrazeno 1 - 10
of 803
pro vyhledávání: '"Xin-yuan Guan"'
Autor:
Hongyu Zhou, Licheng Tan, Baifeng Zhang, Dora Lai Wan Kwong, Ching Ngar Wong, Yu Zhang, Beibei Ru, Yingchen Lyu, Kin To Hugo Siu, Jie Luo, Yuma Yang, Qin Liu, Yixin Chen, Weiguang Zhang, Chaohui He, Peng Jiang, Yanru Qin, Beilei Liu, Xin-Yuan Guan
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Emerging evidence suggests that cancer cells may disseminate early, prior to the formation of traditional macro-metastases. However, the mechanisms underlying the seeding and transition of early disseminated cancer cells (DCCs) into metastat
Externí odkaz:
https://doaj.org/article/141f9175d6024219ae7a8318b41af7f6
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 9, Iss 1, Pp 1-44 (2024)
Abstract Traditional therapeutic approaches such as chemotherapy and radiation therapy have burdened cancer patients with onerous physical and psychological challenges. Encouragingly, the landscape of tumor treatment has undergone a comprehensive and
Externí odkaz:
https://doaj.org/article/45d6dcc984c94e3ebb79061156f9ac88
Autor:
Daqin Suo, Xiaoling Gao, Qingyun Chen, Tingting Zeng, Jiarong Zhan, Guanghui Li, Yinli Zheng, Senlin Zhu, Jingping Yun, Xin-Yuan Guan, Yan Li
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-17 (2024)
Abstract Introduction Gastric cancer (GC) is one of the leading causes of cancer-related death worldwide. Recently, targeted therapies including PD1 (programmed cell death 1) antibodies have been used in advanced GC patients. However, identifying new
Externí odkaz:
https://doaj.org/article/d09f6302784a487a91f68565a33aa4d1
Autor:
Ching Ngar Wong, Yu Zhang, Beibei Ru, Songna Wang, Hongyu Zhou, Jiarun Lin, Yingchen Lyu, Yanru Qin, Peng Jiang, Victor Ho‐Fun Lee, Xin‐Yuan Guan
Publikováno v:
Advanced Science, Vol 11, Iss 30, Pp n/a-n/a (2024)
Abstract Metastasis is the biggest obstacle to esophageal squamous cell carcinoma (ESCC) treatment. Single‐cell RNA sequencing analyses are applied to investigate lung metastatic ESCC cells isolated from pulmonary metastasis mouse model at multiple
Externí odkaz:
https://doaj.org/article/bb0f037d8f5b4b39a3a363d9000640b7
Autor:
Wen Hu, Shao-Lin Ma, Liang Qiong, Yu Du, Li-Ping Gong, Yu-Hang Pan, Li-Ping Sun, Jing-Yun Wen, Jian-Ning Chen, Xin-Yuan Guan, Chun-Kui Shao
Publikováno v:
iScience, Vol 27, Iss 3, Pp 109116- (2024)
Summary: The serine/threonine protein phosphatase family involves series of cellular processes, such as pre-mRNA splicing. The function of one of its members, protein phosphatase, Mg2+/Mn2+ dependent 1G (PPM1G), remains unclear in hepatocellular carc
Externí odkaz:
https://doaj.org/article/754ba15a07d64915afa9b518ed26d62f
Autor:
Lily Liang, Xu Zhang, Xiaodong Su, Tingting Zeng, Daqin Suo, Jingping Yun, Xin Wang, Xin-Yuan Guan, Yan Li
Publikováno v:
Oncogenesis, Vol 12, Iss 1, Pp 1-12 (2023)
Abstract Although many studies have compared tumor fibroblasts (T-Fbs) and nontumor fibroblasts (N-Fbs), less is understood about the stromal contribution of metastatic lymph node fibroblasts (LN-Fbs) to the evolving microenvironment. Here, we explor
Externí odkaz:
https://doaj.org/article/32276336f77346d0997d18ef2ad4cc45
Autor:
Ki-Fong Man, Lei Zhou, Huajian Yu, Ka-Hei Lam, Wei Cheng, Jun Yu, Terence K. Lee, Jing-Ping Yun, Xin-Yuan Guan, Ming Liu, Stephanie Ma
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract Tumor lineage plasticity, considered a hallmark of cancer, denotes the phenomenon in which tumor cells co-opt developmental pathways to attain cellular plasticity, enabling them to evade targeted therapeutic interventions. However, the under
Externí odkaz:
https://doaj.org/article/189114a40a214121a5216f29753810f7
Autor:
Michael King Yung Chung, Lanqi Gong, Dora Lai‐Wan Kwong, Victor Ho‐Fun Lee, Ann Wing‐Mui Lee, Xin‐Yuan Guan, Ngar‐Woon Kam, Wei Dai
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 9, Pp 1-14 (2023)
Abstract Most mature B cells can be divided into four subtypes based on the expression of the surface markers IgD and CD27: IgD+CD27− naïve B cells, IgD+CD27+ unswitched memory B cells, IgD−CD27+ switched memory B cells, and IgD−CD27− double
Externí odkaz:
https://doaj.org/article/78bcf946e0624a75acf06b34b53ade09
Publikováno v:
Advanced Science, Vol 11, Iss 1, Pp n/a-n/a (2024)
Abstract Tumors usually display fetal‐like characteristics, and many oncofetal proteins have been identified. However, fetal‐like reprogramming of RNA splicing in hepatocellular carcinoma (HCC) is poorly understood. Here, it is demonstrated that
Externí odkaz:
https://doaj.org/article/ec9bd40c9781487180b5d28982afd811
Autor:
Lanqi Gong, Jie Luo, Yu Zhang, Yuma Yang, Shanshan Li, Xiaona Fang, Baifeng Zhang, Jiao Huang, Larry Ka-Yue Chow, Dittman Chung, Jinlin Huang, Cuicui Huang, Qin Liu, Lu Bai, Yuen Chak Tiu, Pingan Wu, Yan Wang, George Sai-Wah Tsao, Dora Lai-wan Kwong, Anne Wing-Mui Lee, Wei Dai, Xin-Yuan Guan
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-24 (2023)
Response rates to immunotherapies in patients with nasopharyngeal carcinoma (NPC) are still limited. Here the authors show that tumor-restricted CD70 correlates with regulatory T cell abundance and suppressive activity in NPC and that CD70 blockade i
Externí odkaz:
https://doaj.org/article/b6da0bb5eab74ad7aa459a56759ab2ba