Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Xin-ping Zhao"'
Autor:
Xin-Ping, Zhao, Shiao-Ying, Chang, Yuchao, Pang, Min-Chun, Liao, Junzheng, Peng, Julie R, Ingelfinger, John S D, Chan, Shao-Ling, Zhang
Publikováno v:
Diabetologia. 66:223-240
Senescent renal tubular cells may be linked to diabetic kidney disease (DKD)-related tubulopathy. We studied mice with or without diabetes in which hedgehog interacting protein (HHIP) was present or specifically knocked out in renal tubules (HhipLow-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52af42f7a6e420aaad57c16411ac4dd1
https://doi.org/10.1007/s00125-022-05810-6
https://doi.org/10.1007/s00125-022-05810-6
Autor:
Xin-Ping Zhao, Isabelle Chenier, John S.D. Chan, Shao-Ling Zhang, Julie R. Ingelfinger, Michifumi Yamashita, Shuiling Zhao, Chao-Sheng Lo, Janos G. Filep, Kana N. Miyata
Publikováno v:
Diabetologia
AIMS/HYPOTHESIS: We previously reported that renal tubule-specific deletion of Heterogeneous nuclear ribonucleoprotein F (Hnrnpf) results in upregulation of renal angiotensinogen (Agt) and downregulation of sodium-glucose co-transporter 2 (Sglt2) in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c22e0691c4274bf48b5e06be79b4e842
https://doi.org/10.1007/s00125-021-05538-9
https://doi.org/10.1007/s00125-021-05538-9
Autor:
Shao-Ling Zhang, Xin-Ping Zhao, Julie R. Ingelfinger, Shiao-Ying Chang, Isabelle Chenier, Min-Chun Liao, Yu-Chao Pang, John S.D. Chan
Publikováno v:
Diabetologia. 64:2108-2121
The angiotensin II receptor type 2 (AT2R) may be a potential therapeutic target for the treatment of hypertension and chronic kidney disease (CKD). The expression and function of AT2R in the vasculature and kidney appear sexually dimorphic. We hypoth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dbfb9f6d689704e436f6e4ef7e2c006f
https://doi.org/10.1007/s00125-021-05483-7
https://doi.org/10.1007/s00125-021-05483-7
Autor:
Xin-Ping Zhao, Isabelle Chenier, Shuiling Zhao, Janos G. Filep, John S.D. Chan, Jean-Baptiste Lattouf, Shao-Ling Zhang, Kana N. Miyata, Chao-Sheng Lo, Julie R. Ingelfinger, Jean-François Cailhier, Jean Ethier, Anindya Ghosh
Publikováno v:
Diabetes. 70:1388-1403
We investigated the impact of nuclear factor erythroid 2-related factor 2 (Nrf2) overexpression in renal proximal tubular cells (RPTCs) on blood glucose, kidney injury and sodium-glucose co-transporter 2 (Sglt2) expression in diabetic Akita Nrf2-/-/N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::584b79601ab6992bd62008d3c94c69dc
https://doi.org/10.2337/db20-1126
https://doi.org/10.2337/db20-1126
Autor:
Min-Chun Liao, Kana N. Miyata, Shiao-Ying Chang, Xin-Ping Zhao, Chao-Sheng Lo, Mohamad-Ali El-Mortada, Junzheng Peng, Isabelle Chenier, Michifumi Yamashita, Julie R. Ingelfinger, John S.D. Chan, Shao-Ling Zhang
Publikováno v:
Clin Sci (Lond)
Podocyte damage and loss are the early event in the development of focal segmental glomerulosclerosis (FSGS). Podocytes express angiotensin II type-2-receptor (AT2R), which may play a key role in maintaining kidney integrity and function. Here, we ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::178fe72541339c337e54201b61210f9d
https://europepmc.org/articles/PMC9851172/
https://europepmc.org/articles/PMC9851172/
Increased urinary excretion of hedgehog interacting protein (uHhip) in early diabetic kidney disease
Autor:
Isabelle Chenier, Shao-Ling Zhang, Jean Ethier, Stéphan Troyanov, Min-Chun Liao, Xin-Ping Zhao, Shiao-Ying Chang, Jean-François Cailhier, Kana N. Miyata, Jean-Baptiste Lattouf, John S.D. Chan, Jean-Louis Chiasson, Julie R. Ingelfinger, Chao-Sheng Lo
Publikováno v:
Translational Research. 217:1-10
Glomerular endothelial cell (GEC) dysfunction occurs in diabetic kidney disease (DKD) and generally precedes albuminuria. We recently reported that hedgehog interacting protein (Hhip), highly expressed in GECs, contributes to DKD development in diabe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8944def6547dfca240b7f01c4b2f800
https://doi.org/10.1016/j.trsl.2019.11.001
https://doi.org/10.1016/j.trsl.2019.11.001
Autor:
Min-Chun, Liao, Yu-Chao, Pang, Shiao-Ying, Chang, Xin-Ping, Zhao, Isabelle, Chenier, Julie R, Ingelfinger, John S D, Chan, Shao-Ling, Zhang
Publikováno v:
Diabetologia. 64(9)
The angiotensin II receptor type 2 (ATAge- and sex-matched offspring of non-diabetic and diabetic dams of wild-type (WT) and ATBody weight was progressively lower in female compared with male offspring throughout the lifespan. Female but not male off
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a8f6aaefee0317f16b1a8ddbedaa9f28
https://pubmed.ncbi.nlm.nih.gov/34047808
https://pubmed.ncbi.nlm.nih.gov/34047808
Autor:
Xin-Ping Zhao, Shao-Ling Zhang, Chao-Sheng Lo, John S.D. Chan, Hongyu Luo, Julie R. Ingelfinger, Shiao-Ying Chang, Min-Chun Liao, Isabelle Chenier, Jean-Louis Chiasson
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Scientific Reports
Scientific Reports
We investigated whether renal hedgehog interacting protein (Hhip) expression contributes to the progression of diabetic nephropathy (DN) and studied its related mechanism(s) in vivo and in vitro. Here, we show that Hhip expression is highly elevated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a8b625b2a989c95f99c726c9757ca5b
http://link.springer.com/article/10.1038/s41598-018-24220-6
http://link.springer.com/article/10.1038/s41598-018-24220-6
Autor:
Shao-Ling Zhang, Xin-Ping Zhao, Tomoko Takano, Isabelle Chenier, Shiao-Ying Chang, Julie R. Ingelfinger, Min-Chun Liao, Chao-Sheng Lo
Publikováno v:
The Journal of Pathology. 243:279-293
Angiotensin II type 2 receptor (AT2 R) deficiency in AT2 R knockout (KO) mice has been linked to congenital abnormalities of the kidney and urinary tract; however, the mechanisms by which this occurs are poorly understood. In this study, we examined
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88740eab42f47aae6a6daf80ef789c3b
https://doi.org/10.1002/path.4946
https://doi.org/10.1002/path.4946
Autor:
John S.D. Chan, Xin-Ping Zhao, Min-Chun Liao, Chao-Sheng Lo, Julie R. Ingelfinger, Isabelle Chenier, Shao-Ling Zhang, Henry Nchienzia, Shiao-Ying Chang
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Scientific Reports
Scientific Reports
Hedgehog interacting protein (Hhip) is essential for islet formation and beta-cell proliferation during pancreatic development; abnormally elevated Hhip expression has been linked to human pancreatitis. Here, we investigate the role of Hhip in modula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::696885ce4c026bdd159bea51810ce440
https://doi.org/10.1038/s41598-019-47633-3
https://doi.org/10.1038/s41598-019-47633-3