Zobrazeno 1 - 10 of 66 pro vyhledávání: '"Xin-Yan Pei"'
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Akademický článek
Circumvention of Mcl-1-dependent drug resistance by simultaneous Chk1 and MEK1/2 inhibition in human multiple myeloma cells.
Autor: Xin-Yan Pei, Yun Dai, Jessica Felthousen, Shuang Chen, Yukie Takabatake, Liang Zhou, Leena E Youssefian, Michael W Sanderson, Wesley W Bodie, Lora B Kramer, Robert Z Orlowski, Steven Grant
Publikováno v: PLoS ONE, Vol 9, Iss 3, p e89064 (2014)
The anti-apoptotic protein Mcl-1 plays a major role in multiple myeloma (MM) cell survival as well as bortezomib- and microenvironmental forms of drug resistance in this disease. Consequently, there is a critical need for strategies capable of target
Externí odkaz: https://doaj.org/article/3c9abcdb83b1404890faef5d609aa231
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2
Data from The Novel Chk1 Inhibitor MK-8776 Sensitizes Human Leukemia Cells to HDAC Inhibitors by Targeting the Intra-S Checkpoint and DNA Replication and Repair
Autor: Steven Grant, Xin-Yan Pei, Hui Lin, Liang Zhou, Maciej Kmieciak, Shuang Chen, Yun Dai
Interactions between the novel Chk1 inhibitor MK-8776 and the histone deacetylase (HDAC) inhibitor (HDACI) vorinostat were examined in human leukemia cells harboring wild-type (wt) or deficient p53. MK-8776 synergistically potentiated vorinostat-medi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fab23ba0a47c180e67c5dbeb32b18ae6
https://doi.org/10.1158/1535-7163.c.6536217
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3
Supplementary Table 1, Figures 1 - 6 from The Novel Chk1 Inhibitor MK-8776 Sensitizes Human Leukemia Cells to HDAC Inhibitors by Targeting the Intra-S Checkpoint and DNA Replication and Repair
Autor: Steven Grant, Xin-Yan Pei, Hui Lin, Liang Zhou, Maciej Kmieciak, Shuang Chen, Yun Dai
PDF file - 1275K, Supplemental Table 1. Synergism between MK-8776 and SBHA or vorinostat in various human leukemia cell lines. Supplemental Figure S1. SBHA or vorinostat significantly potentiates lethality of MK-8776 in leukemia cell lines. Supplemen
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61aab150501944d5bbeb91bc867b331f
https://doi.org/10.1158/1535-7163.22499682.v1
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4
Chk1 Inhibition Potently Blocks STAT3 Tyrosine705 Phosphorylation, DNA-Binding Activity, and Activation of Downstream Targets in Human Multiple Myeloma Cells
Autor: Dipankar Bandyopadhyay, Yanxia Ning, Jonathan Yu, Said M. Sebti, Steven Grant, Jewel Nkwocha, Xin-Yan Pei, Liang Zhou, Xiaoyan Hu, Sri Lakshmi Chalasani, Yu Zhang, Lin Li, Kanika Sharma
Publikováno v: Mol Cancer Res
The relationship between the checkpoint kinase Chk1 and the STAT3 pathway was examined in multiple myeloma cells. Gene expression profiling of U266 cells exposed to low (nmol/L) Chk1 inhibitor [PF-477736 (PF)] concentrations revealed STAT3 pathway-re
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64c90c5838afa0a5460902f754ac84fa
https://doi.org/10.1158/1541-7786.mcr-21-0366
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